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Protein
Submitted name:

Glycerol-3-phosphate acyltransferase 1, mitochondrial

Gene

Gpam

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. glycerol-3-phosphate O-acyltransferase activity Source: Ensembl

GO - Biological processi

  1. acyl-CoA metabolic process Source: Ensembl
  2. defense response to virus Source: Ensembl
  3. fatty acid homeostasis Source: Ensembl
  4. fatty acid metabolic process Source: Ensembl
  5. glycerophospholipid metabolic process Source: Ensembl
  6. interleukin-2 secretion Source: Ensembl
  7. negative regulation of activation-induced cell death of T cells Source: Ensembl
  8. phospholipid biosynthetic process Source: InterPro
  9. phospholipid homeostasis Source: Ensembl
  10. positive regulation of activated T cell proliferation Source: Ensembl
  11. positive regulation of multicellular organism growth Source: Ensembl
  12. regulation of cytokine secretion Source: Ensembl
  13. response to glucose Source: Ensembl
  14. triglyceride biosynthetic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Enzyme and pathway databases

ReactomeiREACT_194934. Synthesis of PA.
REACT_198613. Activation of gene expression by SREBF (SREBP).
REACT_232174. Triglyceride Biosynthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Glycerol-3-phosphate acyltransferase 1, mitochondrialImported
Submitted name:
Glycerol-3-phosphate acyltransferase, mitochondrial, isoform CRA_aImported
Gene namesi
Name:GpamImported
ORF Names:rCG_57756Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi61847. Gpam.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Ensembl
  2. plasma membrane Source: InterPro
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00520000055570.
KOiK00629.
OMAiKKNESLW.
OrthoDBiEOG74R1PZ.
TreeFamiTF313360.

Family and domain databases

InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V9J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESSVTIGT IDVSYLPNSS EYSLGRCKHT NEDWVDCGFK PTFFRSATLK
60 70 80 90 100
WKESLMSRKR PFVGRCCYSC TPQSWERFFN PSIPSLGLRN VIYINETHTR
110 120 130 140 150
HRGWLARRLS YILFVQERDV HKGMFATSIT DNVLNSSRVQ EAIAEVAAEL
160 170 180 190 200
NPDGSAQQQS KAIQKVKRKA RKILQEMVAT VSPGMIRLTG WVLLKLFNSF
210 220 230 240 250
FWNIQIHKGQ LEMVKAATET NLPLLFLPVH RSHIDYLLLT FILFCHNIKA
260 270 280 290 300
PYIASGNNLN IPIFSTLIHK LGGFFIRRRL DETPDGRKDI LYRALLHGHI
310 320 330 340 350
VELLRQQQFL EIFLEGTRSR SGKTSCARAG LLSVVVDTLS SNTIPDILVI
360 370 380 390 400
PVGISYDRII EGHYNGEQLG KPKKNESLWS VARGVIRMLR KNYGYVRVDF
410 420 430 440 450
AQPFSLKEYL EGQSQKPVSA PLSLEQALLP AILPSRPDAA AAEHEDMSSN
460 470 480 490 500
ESRNAADEAF RRRLITNLAE HILFTASKSC AIMSTHIVAC LLLYRHRQGI
510 520 530 540 550
HLSTLVEDFF VMKEEVLARD FDLGFSGNSE DVVMHAIQLL GNCVTITHTS
560 570 580 590 600
RKDEFFITPS TTVPSVFELN FYSNGVLHVF IMEAIIACSI YAVQNKRGSG
610 620 630 640 650
GSAGGLGNLI SQEQLVRKAA SLCYLLSNEG TISLPCQTFY QVCHETVGKF
660 670 680 690 700
IQYGILTVAE QDDQEDVSPG LAEQQWNKKL PEPLNWRSDE EDEDSDFGEE
710 720 730 740 750
QRDCYLKVSQ AKEHQQFITF LQRLLGPLLE AYSSAAIFVH TFRGAVPESE
760 770 780 790 800
YLQKLHRYLL TRTERNVAVY AESATYCLVK NAVKMFKDIG VFKETKQKRA
810 820
SVLELSTTFL PQGSRQKLLE YILSFVVL
Length:828
Mass (Da):93,728
Last modified:November 16, 2011 - v1
Checksum:i415606DDB34173FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06011051 Genomic DNA. No translation available.
CH473986 Genomic DNA. Translation: EDL94451.1.
CH473986 Genomic DNA. Translation: EDL94452.1.
CH473986 Genomic DNA. Translation: EDL94453.1.
CH473986 Genomic DNA. Translation: EDL94454.1.
CH473986 Genomic DNA. Translation: EDL94455.1.
CH473986 Genomic DNA. Translation: EDL94456.1.
RefSeqiXP_006231687.1. XM_006231625.2.
XP_006231688.1. XM_006231626.2.
XP_008758756.1. XM_008760534.1.
UniGeneiRn.44456.

Genome annotation databases

EnsembliENSRNOT00000047903; ENSRNOP00000050050; ENSRNOG00000015124.
GeneIDi29653.
KEGGirno:29653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06011051 Genomic DNA. No translation available.
CH473986 Genomic DNA. Translation: EDL94451.1.
CH473986 Genomic DNA. Translation: EDL94452.1.
CH473986 Genomic DNA. Translation: EDL94453.1.
CH473986 Genomic DNA. Translation: EDL94454.1.
CH473986 Genomic DNA. Translation: EDL94455.1.
CH473986 Genomic DNA. Translation: EDL94456.1.
RefSeqiXP_006231687.1. XM_006231625.2.
XP_006231688.1. XM_006231626.2.
XP_008758756.1. XM_008760534.1.
UniGeneiRn.44456.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047903; ENSRNOP00000050050; ENSRNOG00000015124.
GeneIDi29653.
KEGGirno:29653.

Organism-specific databases

CTDi57678.
RGDi61847. Gpam.

Phylogenomic databases

GeneTreeiENSGT00520000055570.
KOiK00629.
OMAiKKNESLW.
OrthoDBiEOG74R1PZ.
TreeFamiTF313360.

Enzyme and pathway databases

ReactomeiREACT_194934. Synthesis of PA.
REACT_198613. Activation of gene expression by SREBF (SREBP).
REACT_232174. Triglyceride Biosynthesis.

Miscellaneous databases

NextBioi35584368.
PROiG3V9J8.

Family and domain databases

InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiG3V9J8_RAT
AccessioniPrimary (citable) accession number: G3V9J8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: February 4, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.