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Protein

Glycerol-3-phosphate acyltransferase 1, mitochondrial

Gene

Gpam

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 3 (Gpat3), Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam), Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam), Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (Agpat4)
  3. Phosphatidate cytidylyltransferase 2 (Cds2), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase 1 (Cds1), Phosphatidate cytidylyltransferase, mitochondrial (Tamm41)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesisUniRule annotation, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-1483166. Synthesis of PA.
R-RNO-2426168. Activation of gene expression by SREBF (SREBP).
R-RNO-75109. Triglyceride Biosynthesis.
UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferase 1, mitochondrialUniRule annotation (EC:2.3.1.15UniRule annotation)
Gene namesi
Name:GpamImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61847. Gpam.

Subcellular locationi

  • Mitochondrion outer membrane UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation, MitochondrionUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiG3V9J8.
PRIDEiG3V9J8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015124.
ExpressionAtlasiG3V9J8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050050.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 302PlsCInterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3729. Eukaryota.
COG2937. LUCA.
GeneTreeiENSGT00520000055570.
TreeFamiTF313360.

Family and domain databases

InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V9J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKRPFVGR CCYSCTPQSW ERFFNPSIPS LGLRNVIYIN ETHTRHRGWL
60 70 80 90 100
ARRLSYILFV QERDVHKGMF ATSITDNVLN SSRVQEAIAE VAAELNPDGS
110 120 130 140 150
AQQQSKAIQK VKRKARKILQ EMVATVSPGM IRLTGWVLLK LFNSFFWNIQ
160 170 180 190 200
IHKGQLEMVK AATETNLPLL FLPVHRSHID YLLLTFILFC HNIKAPYIAS
210 220 230 240 250
GNNLNIPIFS TLIHKLGGFF IRRRLDETPD GRKDILYRAL LHGHIVELLR
260 270 280 290 300
QQQFLEIFLE GTRSRSGKTS CARAGLLSVV VDTLSSNTIP DILVIPVGIS
310 320 330 340 350
YDRIIEGHYN GEQLGKPKKN ESLWSVARGV IRMLRKNYGY VRVDFAQPFS
360 370 380 390 400
LKEYLEGQSQ KPVSAPLSLE QALLPAILPS RPDAAAAEHE DMSSNESRNA
410 420 430 440 450
ADEAFRRRLI TNLAEHILFT ASKSCAIMST HIVACLLLYR HRQGIHLSTL
460 470 480 490 500
VEDFFVMKEE VLARDFDLGF SGNSEDVVMH AIQLLGNCVT ITHTSRKDEF
510 520 530 540 550
FITPSTTVPS VFELNFYSNG VLHVFIMEAI IACSIYAVQN KRGSGGLPEL
560 570 580 590 600
GNLISQEQLV RKAASLCYLL SNEGTISLPC QTFYQVCHET VGKFIQYGIL
610 620 630 640 650
TVAEQDDQED VSPGLAEQQW NKKLPEPLNW RSDEEDEDSD FGEEQRDCYL
660 670 680 690 700
KVSQAKEHQQ FITFLQRLLG PLLEAYSSAA IFVHTFRGAV PESEYLQKLH
710 720 730 740 750
RYLLTRTERN VAVYAESATY CLVKNAVKMF KDIGVFKETK QKRASVLELS
760 770
TTFLPQGSRQ KLLEYILSFV VL
Length:772
Mass (Da):87,521
Last modified:July 22, 2015 - v2
Checksum:i3919093E06C03684
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006998 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSRNOT00000047903; ENSRNOP00000050050; ENSRNOG00000015124.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006998 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050050.

Proteomic databases

PaxDbiG3V9J8.
PRIDEiG3V9J8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047903; ENSRNOP00000050050; ENSRNOG00000015124.

Organism-specific databases

RGDi61847. Gpam.

Phylogenomic databases

eggNOGiKOG3729. Eukaryota.
COG2937. LUCA.
GeneTreeiENSGT00520000055570.
TreeFamiTF313360.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.
ReactomeiR-RNO-1483166. Synthesis of PA.
R-RNO-2426168. Activation of gene expression by SREBF (SREBP).
R-RNO-75109. Triglyceride Biosynthesis.

Gene expression databases

BgeeiENSRNOG00000015124.
ExpressionAtlasiG3V9J8. baseline and differential.

Family and domain databases

InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG3V9J8_RAT
AccessioniPrimary (citable) accession number: G3V9J8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: July 22, 2015
Last modified: November 30, 2016
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.