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G3V9J8

- G3V9J8_RAT

UniProt

G3V9J8 - G3V9J8_RAT

Protein
Submitted name:

Glycerol-3-phosphate acyltransferase 1, mitochondrial

Gene

Gpam

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. glycerol-3-phosphate O-acyltransferase activity Source: Ensembl

    GO - Biological processi

    1. acyl-CoA metabolic process Source: Ensembl
    2. defense response to virus Source: Ensembl
    3. fatty acid homeostasis Source: Ensembl
    4. fatty acid metabolic process Source: Ensembl
    5. glycerophospholipid metabolic process Source: Ensembl
    6. interleukin-2 secretion Source: Ensembl
    7. negative regulation of activation-induced cell death of T cells Source: Ensembl
    8. phospholipid biosynthetic process Source: InterPro
    9. phospholipid homeostasis Source: Ensembl
    10. positive regulation of activated T cell proliferation Source: Ensembl
    11. positive regulation of multicellular organism growth Source: Ensembl
    12. regulation of cytokine secretion Source: Ensembl
    13. response to glucose Source: Ensembl
    14. triglyceride biosynthetic process Source: Ensembl

    Keywords - Molecular functioni

    AcyltransferaseImported, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_194934. Synthesis of PA.
    REACT_198613. Activation of gene expression by SREBF (SREBP).

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glycerol-3-phosphate acyltransferase 1, mitochondrialImported
    Submitted name:
    Glycerol-3-phosphate acyltransferase, mitochondrial, isoform CRA_aImported
    Gene namesi
    Name:GpamImported
    ORF Names:rCG_57756Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi61847. Gpam.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: Ensembl
    2. plasma membrane Source: InterPro

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00520000055570.
    KOiK00629.
    OMAiKKNESLW.
    OrthoDBiEOG74R1PZ.
    TreeFamiTF313360.

    Family and domain databases

    InterProiIPR022284. GPAT/DHAPAT.
    IPR028354. GPAT_PlsB.
    IPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view]
    PANTHERiPTHR12563. PTHR12563. 1 hit.
    PfamiPF01553. Acyltransferase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500064. GPAT. 1 hit.
    PIRSF000437. GPAT_DHAPAT. 1 hit.
    SMARTiSM00563. PlsC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3V9J8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEESSVTIGT IDVSYLPNSS EYSLGRCKHT NEDWVDCGFK PTFFRSATLK    50
    WKESLMSRKR PFVGRCCYSC TPQSWERFFN PSIPSLGLRN VIYINETHTR 100
    HRGWLARRLS YILFVQERDV HKGMFATSIT DNVLNSSRVQ EAIAEVAAEL 150
    NPDGSAQQQS KAIQKVKRKA RKILQEMVAT VSPGMIRLTG WVLLKLFNSF 200
    FWNIQIHKGQ LEMVKAATET NLPLLFLPVH RSHIDYLLLT FILFCHNIKA 250
    PYIASGNNLN IPIFSTLIHK LGGFFIRRRL DETPDGRKDI LYRALLHGHI 300
    VELLRQQQFL EIFLEGTRSR SGKTSCARAG LLSVVVDTLS SNTIPDILVI 350
    PVGISYDRII EGHYNGEQLG KPKKNESLWS VARGVIRMLR KNYGYVRVDF 400
    AQPFSLKEYL EGQSQKPVSA PLSLEQALLP AILPSRPDAA AAEHEDMSSN 450
    ESRNAADEAF RRRLITNLAE HILFTASKSC AIMSTHIVAC LLLYRHRQGI 500
    HLSTLVEDFF VMKEEVLARD FDLGFSGNSE DVVMHAIQLL GNCVTITHTS 550
    RKDEFFITPS TTVPSVFELN FYSNGVLHVF IMEAIIACSI YAVQNKRGSG 600
    GSAGGLGNLI SQEQLVRKAA SLCYLLSNEG TISLPCQTFY QVCHETVGKF 650
    IQYGILTVAE QDDQEDVSPG LAEQQWNKKL PEPLNWRSDE EDEDSDFGEE 700
    QRDCYLKVSQ AKEHQQFITF LQRLLGPLLE AYSSAAIFVH TFRGAVPESE 750
    YLQKLHRYLL TRTERNVAVY AESATYCLVK NAVKMFKDIG VFKETKQKRA 800
    SVLELSTTFL PQGSRQKLLE YILSFVVL 828
    Length:828
    Mass (Da):93,728
    Last modified:November 16, 2011 - v1
    Checksum:i415606DDB34173FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06011051 Genomic DNA. No translation available.
    CH473986 Genomic DNA. Translation: EDL94451.1.
    CH473986 Genomic DNA. Translation: EDL94452.1.
    CH473986 Genomic DNA. Translation: EDL94453.1.
    CH473986 Genomic DNA. Translation: EDL94454.1.
    CH473986 Genomic DNA. Translation: EDL94455.1.
    CH473986 Genomic DNA. Translation: EDL94456.1.
    RefSeqiXP_006231687.1. XM_006231625.1.
    XP_006231688.1. XM_006231626.1.
    UniGeneiRn.44456.

    Genome annotation databases

    EnsembliENSRNOT00000047903; ENSRNOP00000050050; ENSRNOG00000015124.
    GeneIDi29653.
    KEGGirno:29653.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06011051 Genomic DNA. No translation available.
    CH473986 Genomic DNA. Translation: EDL94451.1 .
    CH473986 Genomic DNA. Translation: EDL94452.1 .
    CH473986 Genomic DNA. Translation: EDL94453.1 .
    CH473986 Genomic DNA. Translation: EDL94454.1 .
    CH473986 Genomic DNA. Translation: EDL94455.1 .
    CH473986 Genomic DNA. Translation: EDL94456.1 .
    RefSeqi XP_006231687.1. XM_006231625.1.
    XP_006231688.1. XM_006231626.1.
    UniGenei Rn.44456.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000047903 ; ENSRNOP00000050050 ; ENSRNOG00000015124 .
    GeneIDi 29653.
    KEGGi rno:29653.

    Organism-specific databases

    CTDi 57678.
    RGDi 61847. Gpam.

    Phylogenomic databases

    GeneTreei ENSGT00520000055570.
    KOi K00629.
    OMAi KKNESLW.
    OrthoDBi EOG74R1PZ.
    TreeFami TF313360.

    Enzyme and pathway databases

    Reactomei REACT_194934. Synthesis of PA.
    REACT_198613. Activation of gene expression by SREBF (SREBP).

    Miscellaneous databases

    NextBioi 35584368.
    PROi G3V9J8.

    Family and domain databases

    InterProi IPR022284. GPAT/DHAPAT.
    IPR028354. GPAT_PlsB.
    IPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view ]
    PANTHERi PTHR12563. PTHR12563. 1 hit.
    Pfami PF01553. Acyltransferase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500064. GPAT. 1 hit.
    PIRSF000437. GPAT_DHAPAT. 1 hit.
    SMARTi SM00563. PlsC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V9J8_RAT
    AccessioniPrimary (citable) accession number: G3V9J8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3