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Protein
Submitted name:

Glycerol-3-phosphate acyltransferase 1, mitochondrial

Gene

Gpam

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • glycerol-3-phosphate O-acyltransferase activity Source: RGD

GO - Biological processi

  • cellular response to insulin stimulus Source: RGD
  • phospholipid biosynthetic process Source: InterPro
  • positive regulation of triglyceride biosynthetic process Source: RGD
  • response to activity Source: RGD
  • response to cadmium ion Source: RGD
  • response to fructose Source: RGD
  • response to nutrient levels Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_284108. Synthesis of PA.
REACT_293640. Triglyceride Biosynthesis.
REACT_341940. Activation of gene expression by SREBF (SREBP).

Names & Taxonomyi

Protein namesi
Submitted name:
Glycerol-3-phosphate acyltransferase 1, mitochondrialImported
Gene namesi
Name:GpamImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi61847. Gpam.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial membrane Source: RGD
  • mitochondrial outer membrane Source: RGD
  • mitochondrion Source: RGD
  • plasma membrane Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050050.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00520000055570.
OMAiKKNESLW.
OrthoDBiEOG74R1PZ.
TreeFamiTF313360.

Family and domain databases

InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V9J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKRPFVGR CCYSCTPQSW ERFFNPSIPS LGLRNVIYIN ETHTRHRGWL
60 70 80 90 100
ARRLSYILFV QERDVHKGMF ATSITDNVLN SSRVQEAIAE VAAELNPDGS
110 120 130 140 150
AQQQSKAIQK VKRKARKILQ EMVATVSPGM IRLTGWVLLK LFNSFFWNIQ
160 170 180 190 200
IHKGQLEMVK AATETNLPLL FLPVHRSHID YLLLTFILFC HNIKAPYIAS
210 220 230 240 250
GNNLNIPIFS TLIHKLGGFF IRRRLDETPD GRKDILYRAL LHGHIVELLR
260 270 280 290 300
QQQFLEIFLE GTRSRSGKTS CARAGLLSVV VDTLSSNTIP DILVIPVGIS
310 320 330 340 350
YDRIIEGHYN GEQLGKPKKN ESLWSVARGV IRMLRKNYGY VRVDFAQPFS
360 370 380 390 400
LKEYLEGQSQ KPVSAPLSLE QALLPAILPS RPDAAAAEHE DMSSNESRNA
410 420 430 440 450
ADEAFRRRLI TNLAEHILFT ASKSCAIMST HIVACLLLYR HRQGIHLSTL
460 470 480 490 500
VEDFFVMKEE VLARDFDLGF SGNSEDVVMH AIQLLGNCVT ITHTSRKDEF
510 520 530 540 550
FITPSTTVPS VFELNFYSNG VLHVFIMEAI IACSIYAVQN KRGSGGLPEL
560 570 580 590 600
GNLISQEQLV RKAASLCYLL SNEGTISLPC QTFYQVCHET VGKFIQYGIL
610 620 630 640 650
TVAEQDDQED VSPGLAEQQW NKKLPEPLNW RSDEEDEDSD FGEEQRDCYL
660 670 680 690 700
KVSQAKEHQQ FITFLQRLLG PLLEAYSSAA IFVHTFRGAV PESEYLQKLH
710 720 730 740 750
RYLLTRTERN VAVYAESATY CLVKNAVKMF KDIGVFKETK QKRASVLELS
760 770
TTFLPQGSRQ KLLEYILSFV VL
Length:772
Mass (Da):87,521
Last modified:July 22, 2015 - v2
Checksum:i3919093E06C03684
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006998 Genomic DNA. No translation available.
RefSeqiXP_006231687.1. XM_006231625.2.
XP_006231688.1. XM_006231626.2.
XP_008758756.1. XM_008760534.1.
UniGeneiRn.44456.

Genome annotation databases

EnsembliENSRNOT00000047903; ENSRNOP00000050050; ENSRNOG00000015124.
GeneIDi29653.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07006998 Genomic DNA. No translation available.
RefSeqiXP_006231687.1. XM_006231625.2.
XP_006231688.1. XM_006231626.2.
XP_008758756.1. XM_008760534.1.
UniGeneiRn.44456.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000050050.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047903; ENSRNOP00000050050; ENSRNOG00000015124.
GeneIDi29653.

Organism-specific databases

CTDi57678.
RGDi61847. Gpam.

Phylogenomic databases

GeneTreeiENSGT00520000055570.
OMAiKKNESLW.
OrthoDBiEOG74R1PZ.
TreeFamiTF313360.

Enzyme and pathway databases

ReactomeiREACT_284108. Synthesis of PA.
REACT_293640. Triglyceride Biosynthesis.
REACT_341940. Activation of gene expression by SREBF (SREBP).

Miscellaneous databases

NextBioi35584368.

Family and domain databases

InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 1 hit.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiG3V9J8_RAT
AccessioniPrimary (citable) accession number: G3V9J8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: July 22, 2015
Last modified: July 22, 2015
This is version 28 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.