Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial fission regulator 1

Gene

Mtfr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial fission regulator 1
Gene namesi
Name:Mtfr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1304936. Mtfr1.

Subcellular locationi

  • Mitochondrion By similarity

  • Note: May be associated with the inner and the outer mitochondrial membrane.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4848MitochondrionSequence analysisAdd
BLAST
Chaini49 – 335287Mitochondrial fission regulator 1PRO_0000417555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei119 – 1191PhosphoserineBy similarity
Modified residuei129 – 1291PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiG3V9A7.

PTM databases

iPTMnetiG3V9A7.
PhosphoSiteiG3V9A7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021359.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040894.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni178 – 306129Necessary and sufficient to promote mitochondrial fissionBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili131 – 16737Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi179 – 20527Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the MTFR1 family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiENOG410IEID. Eukaryota.
ENOG4111K5H. LUCA.
GeneTreeiENSGT00530000063223.
HOGENOMiHOG000013162.
HOVERGENiHBG056951.
InParanoidiG3V9A7.
OMAiDMPNMLE.
OrthoDBiEOG091G0DDL.
TreeFamiTF331404.

Family and domain databases

InterProiIPR007972. Mtfr1.
[Graphical view]
PANTHERiPTHR14215. PTHR14215. 1 hit.
PfamiPF05308. Mito_fiss_reg. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

G3V9A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGWIKCLMR MWFQRVGVSM QSVLWSGKPY GSSRSIVRKI GTNLSLIQCP
60 70 80 90 100
RVQFQLTSHA TEWSPTHPGE DVVATFADVG WVATDEGECS TRLRTEVRSK
110 120 130 140 150
PPLENNPPCF EKPPSRHISL PNSSQDKPSP KTTLASEEAL QKISALENEL
160 170 180 190 200
AALRAQIAKI VTLQEQQSPS AGCLDSSTPV IVVPPPPPPP PPPPPLPPPP
210 220 230 240 250
LVLHPSTSAL DLIKERREQR LSAGKTLAKG HPKKLDMPNM LEILKDMNSV
260 270 280 290 300
KLRPVKRSEK DEKPRPVDIT DPAALIAEAL KKKFAYRHRH NSQGEAERGI
310 320 330
PKPESDATSE PALFGPHTLK STGKMKALIE NVSDS
Length:335
Mass (Da):36,815
Last modified:November 16, 2011 - v1
Checksum:i8A23E327A345283A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1831V → VPP in ABN11176 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF221637 mRNA. Translation: ABN11176.1.
CH473961 Genomic DNA. Translation: EDM01060.1.
CH473961 Genomic DNA. Translation: EDM01061.1.
RefSeqiNP_001094447.1. NM_001100977.1.
XP_006232240.1. XM_006232178.2.
XP_006232241.1. XM_006232179.2.
UniGeneiRn.14754.

Genome annotation databases

EnsembliENSRNOT00000045586; ENSRNOP00000040894; ENSRNOG00000021359.
GeneIDi311403.
KEGGirno:311403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF221637 mRNA. Translation: ABN11176.1.
CH473961 Genomic DNA. Translation: EDM01060.1.
CH473961 Genomic DNA. Translation: EDM01061.1.
RefSeqiNP_001094447.1. NM_001100977.1.
XP_006232240.1. XM_006232178.2.
XP_006232241.1. XM_006232179.2.
UniGeneiRn.14754.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040894.

PTM databases

iPTMnetiG3V9A7.
PhosphoSiteiG3V9A7.

Proteomic databases

PaxDbiG3V9A7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045586; ENSRNOP00000040894; ENSRNOG00000021359.
GeneIDi311403.
KEGGirno:311403.

Organism-specific databases

CTDi9650.
RGDi1304936. Mtfr1.

Phylogenomic databases

eggNOGiENOG410IEID. Eukaryota.
ENOG4111K5H. LUCA.
GeneTreeiENSGT00530000063223.
HOGENOMiHOG000013162.
HOVERGENiHBG056951.
InParanoidiG3V9A7.
OMAiDMPNMLE.
OrthoDBiEOG091G0DDL.
TreeFamiTF331404.

Miscellaneous databases

PROiG3V9A7.

Gene expression databases

BgeeiENSRNOG00000021359.

Family and domain databases

InterProiIPR007972. Mtfr1.
[Graphical view]
PANTHERiPTHR14215. PTHR14215. 1 hit.
PfamiPF05308. Mito_fiss_reg. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTFR1_RAT
AccessioniPrimary (citable) accession number: G3V9A7
Secondary accession number(s): A3F823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: November 16, 2011
Last modified: September 7, 2016
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.