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Protein
Submitted name:

Aldehyde dehydrogenase family 5, subfamily A1

Gene

Aldh5a1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-916853. Degradation of GABA.

Names & Taxonomyi

Protein namesi
Submitted name:
Aldehyde dehydrogenase family 5, subfamily A1Imported
Submitted name:
Succinate-semialdehyde dehydrogenase, mitochondrialImported
Gene namesi
Name:Aldh5a1Imported
ORF Names:rCG_45159Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi621422. Aldh5a1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSRNOG00000023538.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035601.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 518457AldedhInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2451. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00840000129936.
KOiK00139.
OMAiLGPLINN.
OrthoDBiEOG091G056Z.
TreeFamiTF352906.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010102. Succ_semiAld_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01780. SSADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATCFLLRNF CAARPALRPP GRLLREPAGA QRRSYVGGPA DLHADLLRGD
60 70 80 90 100
SFVGGRWLPT PATFPVYDPA SGAKLGTVAD CGVPEARAAV RAAYDAFSSW
110 120 130 140 150
KEISVKERSS LLRKWYDLMI QNKDELAKII TAESGKPLKE AQGEILYSAF
160 170 180 190 200
FLEWFSEEAR RVYGDIIYTS AKDKRGLVLK QPVGVASIIT PWNFPSAMIT
210 220 230 240 250
RKVGAALAAG CTVVVKPAED TPYSALALAQ LANQAGIPPG VYNVIPCSRT
260 270 280 290 300
KAKEVGEVLC TDPLVSKISF TGSTATGKIL LHHAANSVKR VSMELGGLAP
310 320 330 340 350
FIVFDSANVD QAVAGAMASK FRNAGQTCVC SNRFLVQRGI HDSFVTKFAE
360 370 380 390 400
AMKKSLRVGN GFEEGTTQGP LINEKAVEKV EKHVNDAVAK GATVVTGGKR
410 420 430 440 450
HQSGGNFFEP TLLSNVTRDM LCITEETFGP LAPVIKFDKE EEAVAIANAA
460 470 480 490 500
DVGLAGYFYS QDPAQIWRVA EQLEVGMVGV NEGLISSVEC PFGGVKQSGL
510 520
GREGSKYGID EYLEVKYVCY GGL
Length:523
Mass (Da):56,145
Last modified:November 16, 2011 - v1
Checksum:iB7518AF38725B22E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07027718 Genomic DNA. No translation available.
CH474064 Genomic DNA. Translation: EDL86492.1.
RefSeqiNP_074042.1. NM_022851.1.
UniGeneiRn.10070.

Genome annotation databases

EnsembliENSRNOT00000031384; ENSRNOP00000035601; ENSRNOG00000023538.
GeneIDi291133.
KEGGirno:291133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07027718 Genomic DNA. No translation available.
CH474064 Genomic DNA. Translation: EDL86492.1.
RefSeqiNP_074042.1. NM_022851.1.
UniGeneiRn.10070.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035601.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000031384; ENSRNOP00000035601; ENSRNOG00000023538.
GeneIDi291133.
KEGGirno:291133.

Organism-specific databases

CTDi7915.
RGDi621422. Aldh5a1.

Phylogenomic databases

eggNOGiKOG2451. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00840000129936.
KOiK00139.
OMAiLGPLINN.
OrthoDBiEOG091G056Z.
TreeFamiTF352906.

Enzyme and pathway databases

ReactomeiR-RNO-916853. Degradation of GABA.

Gene expression databases

BgeeiENSRNOG00000023538.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010102. Succ_semiAld_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01780. SSADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG3V945_RAT
AccessioniPrimary (citable) accession number: G3V945
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 7, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.