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G3V942

- G3V942_RAT

UniProt

G3V942 - G3V942_RAT

Protein
Submitted name:

B2 bradykinin receptor

Gene

Bdkrb2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. bradykinin receptor activity Source: Ensembl

    GO - Biological processi

    1. arachidonic acid secretion Source: Ensembl
    2. negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator Source: Ensembl
    3. negative regulation of peptidyl-serine phosphorylation Source: Ensembl
    4. response to salt stress Source: Ensembl
    5. smooth muscle contraction Source: InterPro
    6. vasoconstriction Source: InterPro
    7. vasodilation Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotation, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    B2 bradykinin receptorImported
    Submitted name:
    Bradykinin receptor, beta 2, isoform CRA_bImported
    Gene namesi
    Name:Bdkrb2Imported
    ORF Names:rCG_27741Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi2201. Bdkrb2.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00720000108671.
    KOiK03916.
    OMAiHKSSCTV.
    TreeFamiTF330024.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001504. Brdyknn_2_rcpt.
    IPR000496. Brdyknn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00425. BRADYKININR.
    PR00994. BRADYKINNB2R.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3V942-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTRSSLCPK TQAVVEVAMF WGPGCHLSTC IEMFNITTQA LGSAHNGTFS    50
    EVNCPDTEWW SWLNAIQAPF LWVLFLLAAL ENIFVLSVFC LHKTNCTVAE 100
    IYLGNLAAAD LILACGLPFW AITIANNFDW LFGEVLCRVV NTMIYMNLYS 150
    SICFLMLVSI DRYLALVKTM SMGRMRGVRW AKLYSLVIWS CTLLLSSPML 200
    VFRTMKDYRE EGHNVTACVI VYPSRSWEVF TNMLLNLVGF LLPLSIITFC 250
    TVRIMQVLRN NEMKKFKEVQ TEKKATVLVL AVLGLFVLCW FPFQISTFLD 300
    TLLRLGVLSG CWNERAVDIV TQISSYVAYS NSCLNPLVYV IVGKRFRKKS 350
    REVYQAICRK GGCMGESVQM ENSMGTLRTS ISVDRQIHKL QDWAGNKQ 398
    Length:398
    Mass (Da):45,190
    Last modified:November 16, 2011 - v1
    Checksum:i0D922543AF71C48B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06046090 Genomic DNA. No translation available.
    CH474034 Genomic DNA. Translation: EDL97607.1.
    RefSeqiNP_001257642.1. NM_001270713.1.
    UniGeneiRn.9845.

    Genome annotation databases

    EnsembliENSRNOT00000074621; ENSRNOP00000064990; ENSRNOG00000047300.
    GeneIDi25245.
    KEGGirno:25245.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06046090 Genomic DNA. No translation available.
    CH474034 Genomic DNA. Translation: EDL97607.1 .
    RefSeqi NP_001257642.1. NM_001270713.1.
    UniGenei Rn.9845.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000074621 ; ENSRNOP00000064990 ; ENSRNOG00000047300 .
    GeneIDi 25245.
    KEGGi rno:25245.

    Organism-specific databases

    CTDi 624.
    RGDi 2201. Bdkrb2.

    Phylogenomic databases

    GeneTreei ENSGT00720000108671.
    KOi K03916.
    OMAi HKSSCTV.
    TreeFami TF330024.

    Miscellaneous databases

    NextBioi 35584278.
    PROi G3V942.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001504. Brdyknn_2_rcpt.
    IPR000496. Brdyknn_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00425. BRADYKININR.
    PR00994. BRADYKINNB2R.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (FEB-2013) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V942_RAT
    AccessioniPrimary (citable) accession number: G3V942
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3