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Protein
Submitted name:

B2 bradykinin receptor

Gene

Bdkrb2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • beta-2 adrenergic receptor binding Source: RGD
  • bradykinin receptor activity Source: RGD

GO - Biological processi

  • acute inflammatory response to antigenic stimulus Source: RGD
  • arachidonic acid secretion Source: Ensembl
  • cellular response to hypoxia Source: RGD
  • maintenance of blood-brain barrier Source: RGD
  • negative regulation of blood pressure Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator Source: Ensembl
  • negative regulation of peptidyl-serine phosphorylation Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • response to drug Source: RGD
  • response to salt stress Source: Ensembl
  • sensory perception of pain Source: RGD
  • smooth muscle contraction Source: InterPro
  • vasoconstriction Source: InterPro
  • vasodilation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
B2 bradykinin receptorImported
Submitted name:
Bradykinin receptor, beta 2, isoform CRA_bImported
Gene namesi
Name:Bdkrb2Imported
ORF Names:rCG_27741Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi2201. Bdkrb2.

Subcellular locationi

GO - Cellular componenti

  • endosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ExpressionAtlasiG3V942. baseline.

Structurei

3D structure databases

ProteinModelPortaliG3V942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119055.
KOiK03916.
OMAiHKSSCTV.
TreeFamiTF330024.

Family and domain databases

InterProiIPR001504. Brdyknn_2_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00994. BRADYKINNB2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTRSSLCPK TQAVVEVAMF WGPGCHLSTC IEMFNITTQA LGSAHNGTFS
60 70 80 90 100
EVNCPDTEWW SWLNAIQAPF LWVLFLLAAL ENIFVLSVFC LHKTNCTVAE
110 120 130 140 150
IYLGNLAAAD LILACGLPFW AITIANNFDW LFGEVLCRVV NTMIYMNLYS
160 170 180 190 200
SICFLMLVSI DRYLALVKTM SMGRMRGVRW AKLYSLVIWS CTLLLSSPML
210 220 230 240 250
VFRTMKDYRE EGHNVTACVI VYPSRSWEVF TNMLLNLVGF LLPLSIITFC
260 270 280 290 300
TVRIMQVLRN NEMKKFKEVQ TEKKATVLVL AVLGLFVLCW FPFQISTFLD
310 320 330 340 350
TLLRLGVLSG CWNERAVDIV TQISSYVAYS NSCLNPLVYV IVGKRFRKKS
360 370 380 390
REVYQAICRK GGCMGESVQM ENSMGTLRTS ISVDRQIHKL QDWAGNKQ
Length:398
Mass (Da):45,190
Last modified:November 16, 2011 - v1
Checksum:i0D922543AF71C48B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06046090 Genomic DNA. No translation available.
CH474034 Genomic DNA. Translation: EDL97607.1.
RefSeqiNP_001257642.1. NM_001270713.1.
UniGeneiRn.9845.

Genome annotation databases

EnsembliENSRNOT00000074621; ENSRNOP00000064990; ENSRNOG00000047300.
GeneIDi25245.
KEGGirno:25245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06046090 Genomic DNA. No translation available.
CH474034 Genomic DNA. Translation: EDL97607.1.
RefSeqiNP_001257642.1. NM_001270713.1.
UniGeneiRn.9845.

3D structure databases

ProteinModelPortaliG3V942.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074621; ENSRNOP00000064990; ENSRNOG00000047300.
GeneIDi25245.
KEGGirno:25245.

Organism-specific databases

CTDi624.
RGDi2201. Bdkrb2.

Phylogenomic databases

GeneTreeiENSGT00760000119055.
KOiK03916.
OMAiHKSSCTV.
TreeFamiTF330024.

Miscellaneous databases

NextBioi35584278.

Gene expression databases

ExpressionAtlasiG3V942. baseline.

Family and domain databases

InterProiIPR001504. Brdyknn_2_rcpt.
IPR000496. Brdyknn_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00425. BRADYKININR.
PR00994. BRADYKINNB2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (FEB-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiG3V942_RAT
AccessioniPrimary (citable) accession number: G3V942
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: May 27, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.