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Protein

Derlin

Gene

Derl3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.UniRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
DerlinUniRule annotation
Gene namesi
Name:Derl3Imported
Synonyms:LOC103694875Imported
ORF Names:rCG_60881Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1597373. Derl3.
9125074. LOC103694875.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 42HelicalUniRule annotationAdd BLAST23
Transmembranei54 – 79HelicalUniRule annotationAdd BLAST26
Transmembranei99 – 132HelicalUniRule annotationAdd BLAST34
Transmembranei153 – 183HelicalUniRule annotationAdd BLAST31

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000028243.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029737.

Family & Domainsi

Sequence similaritiesi

Belongs to the derlin family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG0858. Eukaryota.
COG5291. LUCA.
GeneTreeiENSGT00530000063156.
KOiK13989.
OMAiEEDPNYL.
OrthoDBiEOG091G0IPJ.
TreeFamiTF314715.

Family and domain databases

Gene3Di1.20.1540.10. 1 hit.
InterProiView protein in InterPro
IPR007599. DER1.
IPR035952. Rhomboid-like_sf.
PANTHERiPTHR11009. PTHR11009. 1 hit.
SUPFAMiSSF144091. SSF144091. 1 hit.

Sequencei

Sequence statusi: Complete.

G3V8X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQRLAADF LQVPAVTRAY TAACVLTTAA VQLELLSPFQ LYFNPHLVFR
60 70 80 90 100
KFQVWRLITT FLFFGPLGFG FFFNMLFVFR YCRMLEEGSF RGRKADFVFM
110 120 130 140 150
FLFGGVLMTL LGFLGSMFFL GQALMAMLVY VWSRRSPHVR VNFFGLLNFQ
160 170 180 190 200
APFLPWALMG FSLLLGNSVI TDLLGIIVGH IYYFLEDVFP NQPGGKRLLL
210 220
TPSFLKLLLD DPQEDPNYLP LPEEHPEA
Length:228
Mass (Da):26,082
Last modified:November 16, 2011 - v1
Checksum:i86C3F8FD4037DF2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091362 Genomic DNA. No translation available.
CH473988 Genomic DNA. Translation: EDL97173.1.
RefSeqiNP_001103047.2. NM_001109577.1.
XP_006256387.1. XM_006256325.3.
XP_008772062.1. XM_008773840.2.
XP_008772063.1. XM_008773841.2.
UniGeneiRn.20722.

Genome annotation databases

EnsembliENSRNOT00000038623; ENSRNOP00000029737; ENSRNOG00000028243.
ENSRNOT00000086463; ENSRNOP00000074042; ENSRNOG00000055498.
GeneIDi103694875.
690315.
KEGGirno:690315.

Similar proteinsi

Entry informationi

Entry nameiG3V8X2_RAT
AccessioniPrimary (citable) accession number: G3V8X2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 22, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported