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Protein
Submitted name:

Kelch-like ECH-associated protein 1

Gene

Keap1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • alkanesulfonate metabolic process Source: RGD
  • cellular response to interleukin-4 Source: Ensembl
  • cellular response to organic cyclic compound Source: RGD
  • cytoplasmic sequestering of transcription factor Source: RGD
  • flavonoid metabolic process Source: RGD
  • in utero embryonic development Source: Ensembl
  • malate metabolic process Source: RGD
  • negative regulation of gene expression Source: RGD
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  • positive regulation of protein catabolic process Source: Ensembl
  • proteasomal ubiquitin-independent protein catabolic process Source: Ensembl
  • protein oligomerization Source: RGD
  • protein ubiquitination Source: InterPro
  • regulation of epidermal cell differentiation Source: Ensembl
  • regulation of transcription, DNA-templated Source: Ensembl
  • release of cytochrome c from mitochondria Source: Ensembl
  • response to immobilization stress Source: RGD
  • response to metal ion Source: RGD
  • response to thyroid hormone Source: RGD
  • selenium compound metabolic process Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_312094. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Kelch-like ECH-associated protein 1Imported
Gene namesi
Name:Keap1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621619. Keap1.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: Ensembl
  • cell-cell adherens junction Source: RGD
  • Cul3-RING ubiquitin ligase complex Source: Ensembl
  • cytoplasm Source: RGD
  • endoplasmic reticulum Source: Ensembl
  • focal adhesion Source: RGD
  • microtubule organizing center Source: Ensembl
  • midbody Source: Ensembl
  • mitochondrion Source: Ensembl
  • nucleoplasm Source: Ensembl
  • nucleus Source: RGD
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028360.

Family & Domainsi

Sequence similaritiesi

Contains 1 BTB (POZ) domain.UniRule annotation
Contains Kelch repeats.SAAS annotation

Keywords - Domaini

Kelch repeatSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

OMAiNRRPYVQ.
OrthoDBiEOG76739M.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR030563. KEAP1.
IPR006652. Kelch_1.
[Graphical view]
PANTHERiPTHR24412:SF162. PTHR24412:SF162. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V8U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPEPKPSGA PRSSQFLPLW SKCPEGAGDA VMYASTECKA EVTPSQDGNR
60 70 80 90 100
TFSYTLEDHT KQAFGIMNEL RLSQQLCDVT LQVKYEDIPA AQFMAHKVVL
110 120 130 140 150
ASSSPVFKAM FTNGLREQGM EVVSIEGIHP KVMERLIEFA YTASISVGEK
160 170 180 190 200
CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD PSNAIGIANF AEQIGCTELH
210 220 230 240 250
QRAREYIYMH FGEEEFFNLS HCQLATLISR DDLNVRCESE VFHACIDWVK
260 270 280 290 300
YDCPQRRFYV QALLRAVRCH ALTPRFLQTQ LQKCEILQAD ARCKDYLVQI
310 320 330 340 350
FQELTLHKPT QAVPCRAPKV GRLIYTAGGY FRQSLSYLEA YNPSNGSWLR
360 370 380 390 400
LADLQVPRSG LAGCVVGGLL YAVGGRNNSP DGNTDSSALD CYNPMTNQWS
410 420 430 440 450
PCASMSVPRN RIGVGVIDGH IYAVGGSHGC IHHSSVERYE PDRDEWHLVA
460 470 480 490 500
PMLTRRIGVG VAVLNRLLYA VGGFDGTNRL NSAECYYPER NEWRMITPMN
510 520 530 540 550
TIRSGAGVCV LHSCIYAAGG YDGQDQLNSV ERYDVETETW TFVASMKHRR
560 570 580 590 600
SALGIAVHQG RIYVLGGYDG HTFLDSVECY DPDTDTWSEV TRLTSGRSGV
610 620
GVAVTMEPCR KQIDQQNCTC
Length:620
Mass (Da):69,058
Last modified:July 22, 2015 - v2
Checksum:i2B8E82FC516C9F02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069441 Genomic DNA. No translation available.
AABR07069442 Genomic DNA. No translation available.
RefSeqiXP_006242653.1. XM_006242591.2.
XP_006242654.1. XM_006242592.2.
UniGeneiRn.23467.

Genome annotation databases

EnsembliENSRNOT00000028360; ENSRNOP00000028360; ENSRNOG00000020878.
GeneIDi117519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069441 Genomic DNA. No translation available.
AABR07069442 Genomic DNA. No translation available.
RefSeqiXP_006242653.1. XM_006242591.2.
XP_006242654.1. XM_006242592.2.
UniGeneiRn.23467.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028360.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028360; ENSRNOP00000028360; ENSRNOG00000020878.
GeneIDi117519.

Organism-specific databases

CTDi9817.
RGDi621619. Keap1.

Phylogenomic databases

OMAiNRRPYVQ.
OrthoDBiEOG76739M.
TreeFamiTF329218.

Enzyme and pathway databases

ReactomeiREACT_312094. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

NextBioi35584223.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR017096. BTB-kelch_protein.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR030563. KEAP1.
IPR006652. Kelch_1.
[Graphical view]
PANTHERiPTHR24412:SF162. PTHR24412:SF162. 1 hit.
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiG3V8U2_RAT
AccessioniPrimary (citable) accession number: G3V8U2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: July 22, 2015
Last modified: July 22, 2015
This is version 27 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.