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Protein
Submitted name:

Kelch-like ECH-associated protein 1

Gene

Keap1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-5689880 Ub-specific processing proteases
R-RNO-8951664 Neddylation
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Kelch-like ECH-associated protein 1Imported
Gene namesi
Name:Keap1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621619 Keap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000020878

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiG3V8U2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 149BTBInterPro annotationAdd BLAST73

Keywords - Domaini

Kelch repeatSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118931
KOiK10456
OMAiEQIGCTE
OrthoDBiEOG091G02T3
TreeFamiTF329218

Family and domain databases

Gene3Di2.120.10.801 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR030563 KEAP1
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF162 PTHR24412:SF162, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

G3V8U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPEPKPSGA PRSSQFLPLW SKCPEGAGDA VMYASTECKA EVTPSQDGNR
60 70 80 90 100
TFSYTLEDHT KQAFGIMNEL RLSQQLCDVT LQVKYEDIPA AQFMAHKVVL
110 120 130 140 150
ASSSPVFKAM FTNGLREQGM EVVSIEGIHP KVMERLIEFA YTASISVGEK
160 170 180 190 200
CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD PSNAIGIANF AEQIGCTELH
210 220 230 240 250
QRAREYIYMH FGEEEFFNLS HCQLATLISR DDLNVRCESE VFHACIDWVK
260 270 280 290 300
YDCPQRRFYV QALLRAVRCH ALTPRFLQTQ LQKCEILQAD ARCKDYLVQI
310 320 330 340 350
FQELTLHKPT QAVPCRAPKV GRLIYTAGGY FRQSLSYLEA YNPSNGSWLR
360 370 380 390 400
LADLQVPRSG LAGCVVGGLL YAVGGRNNSP DGNTDSSALD CYNPMTNQWS
410 420 430 440 450
PCASMSVPRN RIGVGVIDGH IYAVGGSHGC IHHSSVERYE PDRDEWHLVA
460 470 480 490 500
PMLTRRIGVG VAVLNRLLYA VGGFDGTNRL NSAECYYPER NEWRMITPMN
510 520 530 540 550
TIRSGAGVCV LHSCIYAAGG YDGQDQLNSV ERYDVETETW TFVASMKHRR
560 570 580 590 600
SALGIAVHQG RIYVLGGYDG HTFLDSVECY DPDTDTWSEV TRLTSGRSGV
610 620
GVAVTMEPCR KQIDQQNCTC
Length:620
Mass (Da):69,058
Last modified:July 22, 2015 - v2
Checksum:i2B8E82FC516C9F02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069441 Genomic DNA No translation available.
AABR07069442 Genomic DNA No translation available.
RefSeqiNP_476493.2, NM_057152.2
UniGeneiRn.23467

Genome annotation databases

EnsembliENSRNOT00000028360; ENSRNOP00000028360; ENSRNOG00000020878
GeneIDi117519
KEGGirno:117519

Similar proteinsi

Entry informationi

Entry nameiG3V8U2_RAT
AccessioniPrimary (citable) accession number: G3V8U2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: July 22, 2015
Last modified: April 25, 2018
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported