G3V8Q9 (G3V8Q9_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Adenomatosis polyposis coli, isoform CRA_a EMBL EDL76212.1

Submitted name:
Adenomatous polyposis coli protein Ensembl ENSRNOP00000027691

Gene names

Name:	Apc RGD 2123 Ensembl ENSRNOP00000027691 EMBL EDL76212.1
ORF Names:	rCG_49353 EMBL EDL76212.1

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000027691

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	2842 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell differentiation in thymus Inferred from electronic annotation. Source: Compara anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara axis specification Inferred from electronic annotation. Source: Compara axonogenesis Inferred from electronic annotation. Source: Compara canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara cell cycle arrest Inferred from electronic annotation. Source: Compara cell migration Inferred from electronic annotation. Source: Compara chromosome organization Inferred from electronic annotation. Source: Compara cytokinesis after mitosis Inferred from electronic annotation. Source: Compara cytoplasmic microtubule organization Inferred from electronic annotation. Source: Compara dorsal/ventral pattern formation Inferred from electronic annotation. Source: Compara hair follicle development Inferred from electronic annotation. Source: Compara kidney development Inferred from electronic annotation. Source: Compara metaphase/anaphase transition of mitotic cell cycle Inferred from electronic annotation. Source: Compara mitotic spindle assembly checkpoint Inferred from electronic annotation. Source: Compara muscle cell homeostasis Inferred from electronic annotation. Source: Compara negative regulation of MAPK cascade Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: Compara negative regulation of epithelial cell proliferation involved in prostate gland development Inferred from electronic annotation. Source: Compara negative regulation of microtubule depolymerization Inferred from electronic annotation. Source: Compara negative regulation of odontogenesis Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of cell adhesion Inferred from electronic annotation. Source: Compara positive regulation of cell division Inferred from electronic annotation. Source: Compara positive regulation of cell migration Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of microtubule polymerization Inferred from electronic annotation. Source: Compara positive regulation of protein catabolic process Inferred from electronic annotation. Source: Compara positive regulation of pseudopodium assembly Inferred from electronic annotation. Source: Compara protein complex assembly Inferred from electronic annotation. Source: Compara proximal/distal pattern formation Inferred from electronic annotation. Source: Compara regulation of attachment of spindle microtubules to kinetochore Inferred from electronic annotation. Source: Compara regulation of nitrogen compound metabolic process Inferred from electronic annotation. Source: Compara regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara regulation of osteoclast differentiation Inferred from electronic annotation. Source: Compara response to DNA damage stimulus Inferred from electronic annotation. Source: Compara retina development in camera-type eye Inferred from electronic annotation. Source: Compara skin development Inferred from electronic annotation. Source: Compara somatic stem cell maintenance Inferred from electronic annotation. Source: Compara thymus development Inferred from electronic annotation. Source: Compara
Cellular_component	axonal growth cone Inferred from electronic annotation. Source: Compara beta-catenin destruction complex Inferred from electronic annotation. Source: Compara cell-cell adherens junction Inferred from electronic annotation. Source: Compara centrosome Inferred from electronic annotation. Source: Compara cytoplasmic microtubule Inferred from electronic annotation. Source: Compara kinetochore Inferred from electronic annotation. Source: Compara lamellipodium Inferred from electronic annotation. Source: Compara lateral plasma membrane Inferred from electronic annotation. Source: Compara microtubule plus end Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara ruffle membrane Inferred from electronic annotation. Source: Compara tight junction Inferred from electronic annotation. Source: Compara
Molecular_function	protein kinase regulator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G3V8Q9 [UniParc]. Last modified November 16, 2011. Version 1. Checksum: F2A2B2083E31C4BD	FASTA	2,842	310,507
	10 20 30 40 50 60 MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTELETE ASNMKEVLKQ LQGSIEDETM 70 80 90 100 110 120 TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS VSSRSGECSP VPMGSFPRRA 130 140 150 160 170 180 FVNGSRESTG YLEELEKERS LLLADLDKEE KEKDWYYAQL QNLTKRIDSL PLTENFSLQT 190 200 210 220 230 240 DMTRRQLEYE ARQIRAAMEE QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA 250 260 270 280 290 300 ERSSQSKHET ASHEAERQLE GQGVAESNLA TSGSGQSSAA RVDHETAGVL SSSGTHSAPR 310 320 330 340 350 360 RLTSHLGTKV EMVYSLLSML GTHDKDDMSR TLLAMSSSQD SCISMRQSGC LPLLIQLLHG 370 380 390 400 410 420 NDKDSVLLGN SRGSKEARAR ASAALHNIIH SQPDDKRGRR EIRVLHLLEQ IRAYCETCWE 430 440 450 460 470 480 WQEAHEQGMD QDKNPMPAPV EHQICPAVCV LMKLSFDEEH RHAMNELGGL QAIAELLQVD 490 500 510 520 530 540 CEMHGLTDDH YSVTLRRYAG MALTNLTFGD VANKATLCSM KGCMRALVAQ LKSESEDLQQ 550 560 570 580 590 600 VIASVLRNLS WRADVNSKKT LREVGSVKAL MECALEVKKE STLKSVLSAL WNLSAHCTEN 610 620 630 640 650 660 KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV SSLIATNEDH RQILRENNCL 670 680 690 700 710 720 QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG AVSMLKNLIH SKHKMIAMGS 730 740 750 760 770 780 AAALRNLMAN RPAKYKDANI MSPGSSLPSL HVRKQKALEA ELDAQHLSET FDNIDNLSPK 790 800 810 820 830 840 ASHRSKQRHK QNLYGDYVFD ASRHDDNRSD NFNTGNMTVL SPYLNTTVLP SSSSSRGSLD 850 860 870 880 890 900 SSRSEKDRSL ERERGIGLST YHSATENPGT SSKRGLQLSA TAAQIAKVME EVSALHTSQD 910 920 930 940 950 960 DRSPASAAEL HCVAEERTAA RRSSASHTHP NTHNFAKSES SNRTCSMPYA KVEYKRSSND 970 980 990 1000 1010 1020 SLNSVTSSDG YGKRGQMKPS VESYSEDDEG KFCSYGQYPA DLAHKIHSAN HMDDNGGELD 1030 1040 1050 1060 1070 1080 TPINYSLKYS DEQLNSGRQS PSQNERWARP KHVIEDEIKQ NEQRQSRSQN TNFPVYSENT 1090 1100 1110 1120 1130 1140 DDKHLKFQQH FGQQECVSPY RSRGTNGSET NRMGSSHAVN QNVNQSLCQE DDYEDDKPTN 1150 1160 1170 1180 1190 1200 YSERYSEEEQ HEEEERPTNY SIKYNEEKHH VDQPIDYSLK YATDISSSQK PSFSFSKTPS 1210 1220 1230 1240 1250 1260 VQGTKTEHNS PSSEAASAPS SNAKRQSQLH PSSAQRNGQT PKGTACKVPS INQETMQTYC 1270 1280 1290 1300 1310 1320 VEDTPICFSR CSSLSSLSSA EDEIGCDQTT QEADSANTLQ IAEIKENDVT RSAQDPASDV 1330 1340 1350 1360 1370 1380 PAVSQSTRTK PSRLQASGLA SESARHKAVE FSSGAKSPSK SGAQTPKSPP EHYVQETPLV 1390 1400 1410 1420 1430 1440 FSRCTSVSSL DSFESRSIAS SVQSEPCSGM VSGIVSPSDL PDSPGQTMPP SRSKTPPPPP 1450 1460 1470 1480 1490 1500 PPQPVQTKRE VPKTKVPAAE QREGGPKQTA VSAAVQRVQV LPDADTLLHF ATESTPDGFS 1510 1520 1530 1540 1550 1560 CSSSLSALSL DEPFIQKDVE LRIMPPVQEN DNGNETEPEQ PEESNENQDK EVEKPDSEKD 1570 1580 1590 1600 1610 1620 LLDDSDDDDI EILEECIISA MPTKSSRKAK KLAQTASKLP PPVARKPSQL PVYKLLPSQS 1630 1640 1650 1660 1670 1680 RLQAQKHVSF TPGDDVPRVY CVEGTPINFS TATSLSDLTI ESPPNELAAG DGVRASVQSG 1690 1700 1710 1720 1730 1740 EFEKRDTIPT EGRSTDEAQR GKVSSIAIPD LDGSKAEEGD ILAECINSAL PKGRSHKPFR 1750 1760 1770 1780 1790 1800 VKKIMDQVQQ ASMTSSGTNK NQIDTKKKKP TSPVKPMPQN TEYRTRVRKN TDSKVNVNTE 1810 1820 1830 1840 1850 1860 ETFSDNKDSK KQSLKNNPKD LNDKLPDNED RVRGGFTFDS PHHYTPIEGT PYCFSRNDSL 1870 1880 1890 1900 1910 1920 SSLDFDDDDV DLSREKAELR KGKESKDSEA KVTCHTEPSS SQQSARKAQA STKHPVNRGP 1930 1940 1950 1960 1970 1980 SKPLLQEQPT FPQSSKDVPD RGAATDEKLQ NFAIENTPVC FSRNSSLSSL SDVDQENNNN 1990 2000 2010 2020 2030 2040 EETGPVRDAE PANAQGQPGK PQASGYAPKS FHVEDTPVCF SRNSSLSSLS IDSEDDLLQE 2050 2060 2070 2080 2090 2100 CISSAMPKKR RPSRLKGEGE RQSPRKVGSV LAEDLTLDLK DIQRPESEHG LSPDSENFDW 2110 2120 2130 2140 2150 2160 KAIQEGANSI VSSLHQAAAA AACLSRQASS DSDSILSLKS GVSLGSPFHL TPDQEEKPFT 2170 2180 2190 2200 2210 2220 SHKGPRILKP GEKSTLEAKK IESENKGIKG GKKVYKSLIT GKIRSNSEIS SQMKQPLQTN 2230 2240 2250 2260 2270 2280 MPSISRGRTM IHIPGVRNSS SSTSPVSKKG PPLKTPASKS PSEGPVATTS PRGTKPAVKS 2290 2300 2310 2320 2330 2340 ELSPITRQTS HISGSNKGPS RSGSRDSTPS RPTQQPLSRP MQSPGRNSIS PGRNGISTPN 2350 2360 2370 2380 2390 2400 KLSQLPRTSS PSTASTKSSG SGKMSYTSPG RQLSQQNLSK QTGLSKNASS IPRSESASKG 2410 2420 2430 2440 2450 2460 LNQMNNSNGS NKKVELSRMS STKSSGSESD RSERPALVRQ STFIKEAPSP TLRRKLEESA 2470 2480 2490 2500 2510 2520 SFESLSPSSR PDSPTRSQAQ TPVLSPSLPD MSLSTHPSVQ AGGWRKLPPN LSPTIEYSDG 2530 2540 2550 2560 2570 2580 RPSKRHDIAR SHSESPSRLP VNRAGTWKRE HSKHSSSLPR VSTWRRTGSS SSILSASSES 2590 2600 2610 2620 2630 2640 SEKAKSEDEK HVNSVPGPRQ MKENQVPTKG TWRKIKESEI SPTNTVSQTT SSGAASGAES 2650 2660 2670 2680 2690 2700 KTLIYQMAPA VSKTEDVWVR IEDCPINNPR SGRSPTGNTP PVIDSISEKG NPSIKDSKDT 2710 2720 2730 2740 2750 2760 QGKQSVGSGS PVQTVGLENR LNSFIQVEAP EQKGTETKAG QSSPAPVAET GETCMAERTP 2770 2780 2790 2800 2810 2820 FSSSSSSKHS SPSGTVAARV TPFNYNPSPR KSSADSTSAR PSQIPTPVGS STKKRDSKTD 2830 2840 STESSGAQSP KRHSGSYLVT SV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000027691.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL76212.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL76212.1.
[4]	Ensembl Submitted (SEP-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000027691.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06094556 Genomic DNA. No translation available. AABR06094557 Genomic DNA. No translation available. CH473974 Genomic DNA. Translation: EDL76212.1. CH473974 Genomic DNA. Translation: EDL76213.1. CH473974 Genomic DNA. Translation: EDL76216.1. CH473974 Genomic DNA. Translation: EDL76217.1.
UniGene	Rn.88057.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000027691; ENSRNOP00000027691; ENSRNOG00000020423.
Organism-specific databases
RGD	2123. Apc.
Phylogenomic databases
GeneTree	ENSGT00530000063749.
OMA	IEDCPIN.
Family and domain databases
Gene3D	1.25.10.10. 2 hits.
InterPro	IPR026836. APC. IPR009240. APC_15aa_rpt. IPR009234. APC_basic_dom. IPR009223. APC_Cys-rich_rpt. IPR026831. APC_dom. IPR026818. Apc_fam. IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000225. Armadillo. IPR009232. EB1-bd. IPR009224. SAMP. [Graphical view]
PANTHER	PTHR12607. PTHR12607. 1 hit. PTHR12607:SF2. PTHR12607:SF2. 1 hit.
Pfam	PF05972. APC_15aa. 4 hits. PF05956. APC_basic. 1 hit. PF05923. APC_crr. 7 hits. PF00514. Arm. 3 hits. PF05937. EB1_binding. 1 hit. PF05924. SAMP. 3 hits. PF11414. Suppressor_APC. 1 hit. [Graphical view]
SMART	SM00185. ARM. 6 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50176. ARM_REPEAT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35584209.

Entry information

Entry name

G3V8Q9_RAT

Accession

Primary (citable) accession number: G3V8Q9

Entry history

Integrated into UniProtKB/TrEMBL:	November 16, 2011
Last sequence update:	November 16, 2011
Last modified:	May 29, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)