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G3V8Q9

- G3V8Q9_RAT

UniProt

G3V8Q9 - G3V8Q9_RAT

Protein
Submitted name:

Adenomatosis polyposis coli, isoform CRA_a

Gene

Apc

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein kinase regulator activity Source: Ensembl

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. axis specification Source: Ensembl
    3. axonogenesis Source: Ensembl
    4. canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: Ensembl
    5. canonical Wnt signaling pathway involved in positive regulation of apoptotic process Source: Ensembl
    6. cell cycle arrest Source: InterPro
    7. cell migration Source: Ensembl
    8. cellular response to DNA damage stimulus Source: InterPro
    9. chromosome organization Source: Ensembl
    10. cytoplasmic microtubule organization Source: Ensembl
    11. dorsal/ventral pattern formation Source: Ensembl
    12. hair follicle development Source: Ensembl
    13. kidney development Source: Ensembl
    14. metaphase/anaphase transition of mitotic cell cycle Source: Ensembl
    15. mitotic cytokinesis Source: Ensembl
    16. mitotic spindle assembly checkpoint Source: Ensembl
    17. muscle cell cellular homeostasis Source: Ensembl
    18. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    19. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    20. negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
    21. negative regulation of MAPK cascade Source: Ensembl
    22. negative regulation of microtubule depolymerization Source: Ensembl
    23. negative regulation of odontogenesis Source: Ensembl
    24. positive regulation of cell adhesion Source: Ensembl
    25. positive regulation of cell division Source: Ensembl
    26. positive regulation of cell migration Source: Ensembl
    27. positive regulation of epithelial cell differentiation Source: Ensembl
    28. positive regulation of microtubule polymerization Source: Ensembl
    29. positive regulation of protein catabolic process Source: Ensembl
    30. positive regulation of pseudopodium assembly Source: Ensembl
    31. protein complex assembly Source: Ensembl
    32. proximal/distal pattern formation Source: Ensembl
    33. regulation of attachment of spindle microtubules to kinetochore Source: Ensembl
    34. regulation of nitrogen compound metabolic process Source: Ensembl
    35. regulation of osteoblast differentiation Source: Ensembl
    36. regulation of osteoclast differentiation Source: Ensembl
    37. retina development in camera-type eye Source: Ensembl
    38. somatic stem cell maintenance Source: Ensembl
    39. T cell differentiation in thymus Source: Ensembl
    40. thymus development Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_214025. deactivation of the beta-catenin transactivating complex.
    REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Adenomatosis polyposis coli, isoform CRA_aImported
    Submitted name:
    Adenomatous polyposis coli proteinImported
    Gene namesi
    Name:ApcImported
    ORF Names:rCG_49353Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 18

    Organism-specific databases

    RGDi2123. Apc.

    Subcellular locationi

    GO - Cellular componenti

    1. axonal growth cone Source: Ensembl
    2. beta-catenin destruction complex Source: Ensembl
    3. cell-cell adherens junction Source: Ensembl
    4. centrosome Source: Ensembl
    5. cytoplasmic microtubule Source: Ensembl
    6. kinetochore Source: Ensembl
    7. lamellipodium Source: Ensembl
    8. lateral plasma membrane Source: Ensembl
    9. microtubule plus-end Source: Ensembl
    10. nucleus Source: Ensembl
    11. ruffle membrane Source: Ensembl
    12. tight junction Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000063749.
    KOiK02085.
    OMAiIEDCPIN.
    OrthoDBiEOG7BCN9S.
    TreeFamiTF106496.

    Family and domain databases

    Gene3Di1.25.10.10. 2 hits.
    InterProiIPR026836. APC.
    IPR009240. APC_15aa_rpt.
    IPR009234. APC_basic_dom.
    IPR009223. APC_Cys-rich_rpt.
    IPR026831. APC_dom.
    IPR026818. Apc_fam.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR009232. EB1-bd.
    IPR009224. SAMP.
    [Graphical view]
    PANTHERiPTHR12607. PTHR12607. 1 hit.
    PTHR12607:SF11. PTHR12607:SF11. 1 hit.
    PfamiPF05972. APC_15aa. 4 hits.
    PF05956. APC_basic. 1 hit.
    PF05923. APC_crr. 7 hits.
    PF00514. Arm. 3 hits.
    PF05937. EB1_binding. 1 hit.
    PF05924. SAMP. 3 hits.
    PF11414. Suppressor_APC. 1 hit.
    [Graphical view]
    SMARTiSM00185. ARM. 6 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS50176. ARM_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3V8Q9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTELETE ASNMKEVLKQ     50
    LQGSIEDETM TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS 100
    VSSRSGECSP VPMGSFPRRA FVNGSRESTG YLEELEKERS LLLADLDKEE 150
    KEKDWYYAQL QNLTKRIDSL PLTENFSLQT DMTRRQLEYE ARQIRAAMEE 200
    QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA ERSSQSKHET 250
    ASHEAERQLE GQGVAESNLA TSGSGQSSAA RVDHETAGVL SSSGTHSAPR 300
    RLTSHLGTKV EMVYSLLSML GTHDKDDMSR TLLAMSSSQD SCISMRQSGC 350
    LPLLIQLLHG NDKDSVLLGN SRGSKEARAR ASAALHNIIH SQPDDKRGRR 400
    EIRVLHLLEQ IRAYCETCWE WQEAHEQGMD QDKNPMPAPV EHQICPAVCV 450
    LMKLSFDEEH RHAMNELGGL QAIAELLQVD CEMHGLTDDH YSVTLRRYAG 500
    MALTNLTFGD VANKATLCSM KGCMRALVAQ LKSESEDLQQ VIASVLRNLS 550
    WRADVNSKKT LREVGSVKAL MECALEVKKE STLKSVLSAL WNLSAHCTEN 600
    KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV SSLIATNEDH 650
    RQILRENNCL QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG 700
    AVSMLKNLIH SKHKMIAMGS AAALRNLMAN RPAKYKDANI MSPGSSLPSL 750
    HVRKQKALEA ELDAQHLSET FDNIDNLSPK ASHRSKQRHK QNLYGDYVFD 800
    ASRHDDNRSD NFNTGNMTVL SPYLNTTVLP SSSSSRGSLD SSRSEKDRSL 850
    ERERGIGLST YHSATENPGT SSKRGLQLSA TAAQIAKVME EVSALHTSQD 900
    DRSPASAAEL HCVAEERTAA RRSSASHTHP NTHNFAKSES SNRTCSMPYA 950
    KVEYKRSSND SLNSVTSSDG YGKRGQMKPS VESYSEDDEG KFCSYGQYPA 1000
    DLAHKIHSAN HMDDNGGELD TPINYSLKYS DEQLNSGRQS PSQNERWARP 1050
    KHVIEDEIKQ NEQRQSRSQN TNFPVYSENT DDKHLKFQQH FGQQECVSPY 1100
    RSRGTNGSET NRMGSSHAVN QNVNQSLCQE DDYEDDKPTN YSERYSEEEQ 1150
    HEEEERPTNY SIKYNEEKHH VDQPIDYSLK YATDISSSQK PSFSFSKTPS 1200
    VQGTKTEHNS PSSEAASAPS SNAKRQSQLH PSSAQRNGQT PKGTACKVPS 1250
    INQETMQTYC VEDTPICFSR CSSLSSLSSA EDEIGCDQTT QEADSANTLQ 1300
    IAEIKENDVT RSAQDPASDV PAVSQSTRTK PSRLQASGLA SESARHKAVE 1350
    FSSGAKSPSK SGAQTPKSPP EHYVQETPLV FSRCTSVSSL DSFESRSIAS 1400
    SVQSEPCSGM VSGIVSPSDL PDSPGQTMPP SRSKTPPPPP PPQPVQTKRE 1450
    VPKTKVPAAE QREGGPKQTA VSAAVQRVQV LPDADTLLHF ATESTPDGFS 1500
    CSSSLSALSL DEPFIQKDVE LRIMPPVQEN DNGNETEPEQ PEESNENQDK 1550
    EVEKPDSEKD LLDDSDDDDI EILEECIISA MPTKSSRKAK KLAQTASKLP 1600
    PPVARKPSQL PVYKLLPSQS RLQAQKHVSF TPGDDVPRVY CVEGTPINFS 1650
    TATSLSDLTI ESPPNELAAG DGVRASVQSG EFEKRDTIPT EGRSTDEAQR 1700
    GKVSSIAIPD LDGSKAEEGD ILAECINSAL PKGRSHKPFR VKKIMDQVQQ 1750
    ASMTSSGTNK NQIDTKKKKP TSPVKPMPQN TEYRTRVRKN TDSKVNVNTE 1800
    ETFSDNKDSK KQSLKNNPKD LNDKLPDNED RVRGGFTFDS PHHYTPIEGT 1850
    PYCFSRNDSL SSLDFDDDDV DLSREKAELR KGKESKDSEA KVTCHTEPSS 1900
    SQQSARKAQA STKHPVNRGP SKPLLQEQPT FPQSSKDVPD RGAATDEKLQ 1950
    NFAIENTPVC FSRNSSLSSL SDVDQENNNN EETGPVRDAE PANAQGQPGK 2000
    PQASGYAPKS FHVEDTPVCF SRNSSLSSLS IDSEDDLLQE CISSAMPKKR 2050
    RPSRLKGEGE RQSPRKVGSV LAEDLTLDLK DIQRPESEHG LSPDSENFDW 2100
    KAIQEGANSI VSSLHQAAAA AACLSRQASS DSDSILSLKS GVSLGSPFHL 2150
    TPDQEEKPFT SHKGPRILKP GEKSTLEAKK IESENKGIKG GKKVYKSLIT 2200
    GKIRSNSEIS SQMKQPLQTN MPSISRGRTM IHIPGVRNSS SSTSPVSKKG 2250
    PPLKTPASKS PSEGPVATTS PRGTKPAVKS ELSPITRQTS HISGSNKGPS 2300
    RSGSRDSTPS RPTQQPLSRP MQSPGRNSIS PGRNGISTPN KLSQLPRTSS 2350
    PSTASTKSSG SGKMSYTSPG RQLSQQNLSK QTGLSKNASS IPRSESASKG 2400
    LNQMNNSNGS NKKVELSRMS STKSSGSESD RSERPALVRQ STFIKEAPSP 2450
    TLRRKLEESA SFESLSPSSR PDSPTRSQAQ TPVLSPSLPD MSLSTHPSVQ 2500
    AGGWRKLPPN LSPTIEYSDG RPSKRHDIAR SHSESPSRLP VNRAGTWKRE 2550
    HSKHSSSLPR VSTWRRTGSS SSILSASSES SEKAKSEDEK HVNSVPGPRQ 2600
    MKENQVPTKG TWRKIKESEI SPTNTVSQTT SSGAASGAES KTLIYQMAPA 2650
    VSKTEDVWVR IEDCPINNPR SGRSPTGNTP PVIDSISEKG NPSIKDSKDT 2700
    QGKQSVGSGS PVQTVGLENR LNSFIQVEAP EQKGTETKAG QSSPAPVAET 2750
    GETCMAERTP FSSSSSSKHS SPSGTVAARV TPFNYNPSPR KSSADSTSAR 2800
    PSQIPTPVGS STKKRDSKTD STESSGAQSP KRHSGSYLVT SV 2842
    Length:2,842
    Mass (Da):310,507
    Last modified:November 16, 2011 - v1
    Checksum:iF2A2B2083E31C4BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06094556 Genomic DNA. No translation available.
    AABR06094557 Genomic DNA. No translation available.
    CH473974 Genomic DNA. Translation: EDL76212.1.
    CH473974 Genomic DNA. Translation: EDL76213.1.
    CH473974 Genomic DNA. Translation: EDL76216.1.
    CH473974 Genomic DNA. Translation: EDL76217.1.
    RefSeqiXP_006254573.1. XM_006254511.1.
    UniGeneiRn.156346.
    Rn.88057.

    Genome annotation databases

    EnsembliENSRNOT00000027691; ENSRNOP00000027691; ENSRNOG00000020423.
    GeneIDi24205.
    KEGGirno:24205.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06094556 Genomic DNA. No translation available.
    AABR06094557 Genomic DNA. No translation available.
    CH473974 Genomic DNA. Translation: EDL76212.1 .
    CH473974 Genomic DNA. Translation: EDL76213.1 .
    CH473974 Genomic DNA. Translation: EDL76216.1 .
    CH473974 Genomic DNA. Translation: EDL76217.1 .
    RefSeqi XP_006254573.1. XM_006254511.1.
    UniGenei Rn.156346.
    Rn.88057.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000027691 ; ENSRNOP00000027691 ; ENSRNOG00000020423 .
    GeneIDi 24205.
    KEGGi rno:24205.

    Organism-specific databases

    CTDi 324.
    RGDi 2123. Apc.

    Phylogenomic databases

    GeneTreei ENSGT00530000063749.
    KOi K02085.
    OMAi IEDCPIN.
    OrthoDBi EOG7BCN9S.
    TreeFami TF106496.

    Enzyme and pathway databases

    Reactomei REACT_214025. deactivation of the beta-catenin transactivating complex.
    REACT_216976. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Miscellaneous databases

    NextBioi 35584209.
    PROi G3V8Q9.

    Family and domain databases

    Gene3Di 1.25.10.10. 2 hits.
    InterProi IPR026836. APC.
    IPR009240. APC_15aa_rpt.
    IPR009234. APC_basic_dom.
    IPR009223. APC_Cys-rich_rpt.
    IPR026831. APC_dom.
    IPR026818. Apc_fam.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000225. Armadillo.
    IPR009232. EB1-bd.
    IPR009224. SAMP.
    [Graphical view ]
    PANTHERi PTHR12607. PTHR12607. 1 hit.
    PTHR12607:SF11. PTHR12607:SF11. 1 hit.
    Pfami PF05972. APC_15aa. 4 hits.
    PF05956. APC_basic. 1 hit.
    PF05923. APC_crr. 7 hits.
    PF00514. Arm. 3 hits.
    PF05937. EB1_binding. 1 hit.
    PF05924. SAMP. 3 hits.
    PF11414. Suppressor_APC. 1 hit.
    [Graphical view ]
    SMARTi SM00185. ARM. 6 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS50176. ARM_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V8Q9_RAT
    AccessioniPrimary (citable) accession number: G3V8Q9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3