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Protein
Submitted name:

Phosphodiesterase 4C, cAMP-specific, isoform CRA_b

Gene

Pde4c

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Cofactori

a divalent metal cationSAAS annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.SAAS annotation

GO - Molecular functioni

  1. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Keywords - Ligandi

Metal-bindingSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_287445. G alpha (s) signalling events.
REACT_348359. DARPP-32 events.

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphodiesterase 4C, cAMP-specific, isoform CRA_bImported
Submitted name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4CImported
Gene namesi
Name:Pde4cImported
Synonyms:Dpde1Imported
ORF Names:rCG_38833Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi727918. Pde4c.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. primary cilium Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliG3V8J8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118889.
KOiK13293.
OMAiLQAENCN.
OrthoDBiEOG7HQNBC.
TreeFamiTF314638.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V8J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSGTTLSF LLTERVREPV DSGVAPVSHL GGGVILRRFS GTLLLPPLSS
60 70 80 90 100
RLGSSGEAES AAPVVFTIGS RGTERSHGSA QSSFDLENGL PSGRGPLDAQ
110 120 130 140 150
SGSSLGRALQ PPVHHGQRRE SFLYRSDSDH EPSPKAVSRT SSAASDLHGE
160 170 180 190 200
DMIVTPFAQV LASLRTVRSN VAALAHGAGS ATRQALLGTP PQSSQQAAPA
210 220 230 240 250
EESGLQLAQE TLEELDWCLE QLETLQTRRS VGEMASNKFK RMLNRELTHL
260 270 280 290 300
SETSRSGNQV SEYISQTFLD QQAEVELPAP PTEDHPWPMA QITGLRKSCH
310 320 330 340 350
TSLPTAAIPR FGVQTDQEEQ LAKELEDTNK WGFDVFKVAE LSGNRPLTAV
360 370 380 390 400
IFSVLQERDL LKTFQIPADT LLRYLLTLEG HYHSNVAYHN SIHAADVVQS
410 420 430 440 450
AHVLLGTPAL EAVFTDLEVL AAIFACAIHD VDHPGVSNQF LINTNSELAL
460 470 480 490 500
MYNDSSVLEN HHLAVGFKLL QGENCDIFQN LSTKQKLSLR RMVIDMVLAT
510 520 530 540 550
DMSKHMSLLA DLKTMVETKK VTSLGVLLLD NYSDRIQVLQ SLVHCADLSN
560 570 580 590 600
PAKPLPLYRQ WTERIMAEFF QQGDRERESG LDISPMCDKH TASVEKSQVG
610 620 630 640 650
FIDYIAHPLW ETWADLVHPD AQELLDTLED NREWYQSRVP CSPPHAIGPD
660 670
RFKFELTLEE TEEEEEEDER H
Length:671
Mass (Da):74,238
Last modified:November 16, 2011 - v1
Checksum:i0ED8A4FB34962FA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06086857 Genomic DNA. No translation available.
CH474031 Genomic DNA. Translation: EDL90730.1.
RefSeqiNP_001263694.1. NM_001276765.1.
XP_006252930.1. XM_006252868.2.
UniGeneiRn.214181.
Rn.92465.

Genome annotation databases

EnsembliENSRNOT00000026457; ENSRNOP00000026457; ENSRNOG00000019518.
GeneIDi290646.
KEGGirno:290646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06086857 Genomic DNA. No translation available.
CH474031 Genomic DNA. Translation: EDL90730.1.
RefSeqiNP_001263694.1. NM_001276765.1.
XP_006252930.1. XM_006252868.2.
UniGeneiRn.214181.
Rn.92465.

3D structure databases

ProteinModelPortaliG3V8J8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026457; ENSRNOP00000026457; ENSRNOG00000019518.
GeneIDi290646.
KEGGirno:290646.

Organism-specific databases

CTDi5143.
RGDi727918. Pde4c.

Phylogenomic databases

GeneTreeiENSGT00760000118889.
KOiK13293.
OMAiLQAENCN.
OrthoDBiEOG7HQNBC.
TreeFamiTF314638.

Enzyme and pathway databases

ReactomeiREACT_287445. G alpha (s) signalling events.
REACT_348359. DARPP-32 events.

Miscellaneous databases

NextBioi631402.
PROiG3V8J8.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (AUG-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiG3V8J8_RAT
AccessioniPrimary (citable) accession number: G3V8J8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 1, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.