Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

G3V8J8 (G3V8J8_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

cAMP-specific 3',5'-cyclic phosphodiesterase 4C Ensembl ENSRNOP00000026457
Gene names
Name:Pde4c Ensembl ENSRNOP00000026457 RGD 727918
Synonyms:Dpde1 EMBL EDL90730.1
ORF Names:rCG_38833 EMBL EDL90730.1
OrganismRattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000026457
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length671 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity. SAAS SAAS023174

Ontologies

Sequences

Sequence LengthMass (Da)Tools
G3V8J8 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: 0ED8A4FB34962FA9

FASTA67174,238
        10         20         30         40         50         60 
MRRSGTTLSF LLTERVREPV DSGVAPVSHL GGGVILRRFS GTLLLPPLSS RLGSSGEAES 

        70         80         90        100        110        120 
AAPVVFTIGS RGTERSHGSA QSSFDLENGL PSGRGPLDAQ SGSSLGRALQ PPVHHGQRRE 

       130        140        150        160        170        180 
SFLYRSDSDH EPSPKAVSRT SSAASDLHGE DMIVTPFAQV LASLRTVRSN VAALAHGAGS 

       190        200        210        220        230        240 
ATRQALLGTP PQSSQQAAPA EESGLQLAQE TLEELDWCLE QLETLQTRRS VGEMASNKFK 

       250        260        270        280        290        300 
RMLNRELTHL SETSRSGNQV SEYISQTFLD QQAEVELPAP PTEDHPWPMA QITGLRKSCH 

       310        320        330        340        350        360 
TSLPTAAIPR FGVQTDQEEQ LAKELEDTNK WGFDVFKVAE LSGNRPLTAV IFSVLQERDL 

       370        380        390        400        410        420 
LKTFQIPADT LLRYLLTLEG HYHSNVAYHN SIHAADVVQS AHVLLGTPAL EAVFTDLEVL 

       430        440        450        460        470        480 
AAIFACAIHD VDHPGVSNQF LINTNSELAL MYNDSSVLEN HHLAVGFKLL QGENCDIFQN 

       490        500        510        520        530        540 
LSTKQKLSLR RMVIDMVLAT DMSKHMSLLA DLKTMVETKK VTSLGVLLLD NYSDRIQVLQ 

       550        560        570        580        590        600 
SLVHCADLSN PAKPLPLYRQ WTERIMAEFF QQGDRERESG LDISPMCDKH TASVEKSQVG 

       610        620        630        640        650        660 
FIDYIAHPLW ETWADLVHPD AQELLDTLED NREWYQSRVP CSPPHAIGPD RFKFELTLEE 

       670 
TEEEEEEDER H 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000026457.
[2]"Gene and alternative splicing annotation with AIR."
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G.
Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL90730.1.
[3]Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. expand/collapse author list , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL90730.1.
[4]Ensembl
Submitted (SEP-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000026457.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06086857 Genomic DNA. No translation available.
CH474031 Genomic DNA. Translation: EDL90730.1.
RefSeqNP_001263694.1. NM_001276765.1.
XP_006252930.1. XM_006252868.1.
UniGeneRn.214181.
Rn.92465.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000026457; ENSRNOP00000026457; ENSRNOG00000019518.
GeneID290646.
KEGGrno:290646.

Organism-specific databases

CTD5143.
RGD727918. Pde4c.

Phylogenomic databases

GeneTreeENSGT00740000115148.
KOK01120.
OMAGENCDIF.
OrthoDBEOG7HQNBC.
TreeFamTF314638.

Family and domain databases

Gene3D1.10.1300.10. 1 hit.
InterProIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio631402.
PROG3V8J8.

Entry information

Entry nameG3V8J8_RAT
AccessionPrimary (citable) accession number: G3V8J8
Entry history
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 16, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)