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Protein

Phosphodiesterase

Gene

Pde4c

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-180024. DARPP-32 events.
R-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
PhosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Gene namesi
Name:Pde4cImported
Synonyms:Dpde1Imported
ORF Names:rCG_38833Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi727918. Pde4c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSRNOG00000019518.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026457.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini386 – 561176HDcInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3689. Eukaryota.
ENOG410XRI7. LUCA.
GeneTreeiENSGT00760000118889.
KOiK13293.
OMAiEDTNRWG.
OrthoDBiEOG091G06CD.
TreeFamiTF314638.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V8J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSGTTLSF LLTERVREPV DSGVAPVSHL GGGVILRRFS GTLLLPPLSS
60 70 80 90 100
RLGSSGEAES AAPVVFTIGS RGTERSHGSA QSSFDLENGL PSGRGPLDAQ
110 120 130 140 150
SGSSLGRALQ PPVHHGQRRE SFLYRSDSDH EPSPKAVSRT SSAASDLHGE
160 170 180 190 200
DMIVTPFAQV LASLRTVRSN VAALAHGAGS ATRQALLGTP PQSSQQAAPA
210 220 230 240 250
EESGLQLAQE TLEELDWCLE QLETLQTRRS VGEMASNKFK RMLNRELTHL
260 270 280 290 300
SETSRSGNQV SEYISQTFLD QQAEVELPAP PTEDHPWPMA QITGLRKSCH
310 320 330 340 350
TSLPTAAIPR FGVQTDQEEQ LAKELEDTNK WGFDVFKVAE LSGNRPLTAV
360 370 380 390 400
IFSVLQERDL LKTFQIPADT LLRYLLTLEG HYHSNVAYHN SIHAADVVQS
410 420 430 440 450
AHVLLGTPAL EAVFTDLEVL AAIFACAIHD VDHPGVSNQF LINTNSELAL
460 470 480 490 500
MYNDSSVLEN HHLAVGFKLL QGENCDIFQN LSTKQKLSLR RMVIDMVLAT
510 520 530 540 550
DMSKHMSLLA DLKTMVETKK VTSLGVLLLD NYSDRIQVLQ SLVHCADLSN
560 570 580 590 600
PAKPLPLYRQ WTERIMAEFF QQGDRERESG LDISPMCDKH TASVEKSQVG
610 620 630 640 650
FIDYIAHPLW ETWADLVHPD AQELLDTLED NREWYQSRVP CSPPHAIGPD
660 670
RFKFELTLEE TEEEEEEDER H
Length:671
Mass (Da):74,238
Last modified:November 16, 2011 - v1
Checksum:i0ED8A4FB34962FA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07024876 Genomic DNA. No translation available.
CH474031 Genomic DNA. Translation: EDL90730.1.
RefSeqiNP_001263694.1. NM_001276765.1.
XP_006252930.1. XM_006252868.2.
UniGeneiRn.214181.
Rn.92465.

Genome annotation databases

EnsembliENSRNOT00000026457; ENSRNOP00000026457; ENSRNOG00000019518.
GeneIDi290646.
KEGGirno:290646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07024876 Genomic DNA. No translation available.
CH474031 Genomic DNA. Translation: EDL90730.1.
RefSeqiNP_001263694.1. NM_001276765.1.
XP_006252930.1. XM_006252868.2.
UniGeneiRn.214181.
Rn.92465.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026457.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026457; ENSRNOP00000026457; ENSRNOG00000019518.
GeneIDi290646.
KEGGirno:290646.

Organism-specific databases

CTDi5143.
RGDi727918. Pde4c.

Phylogenomic databases

eggNOGiKOG3689. Eukaryota.
ENOG410XRI7. LUCA.
GeneTreeiENSGT00760000118889.
KOiK13293.
OMAiEDTNRWG.
OrthoDBiEOG091G06CD.
TreeFamiTF314638.

Enzyme and pathway databases

ReactomeiR-RNO-180024. DARPP-32 events.
R-RNO-418555. G alpha (s) signalling events.

Gene expression databases

BgeeiENSRNOG00000019518.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
InterProiIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00471. HDc. 1 hit.
[Graphical view]
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG3V8J8_RAT
AccessioniPrimary (citable) accession number: G3V8J8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 7, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.