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G3V8J8

- G3V8J8_RAT

UniProt

G3V8J8 - G3V8J8_RAT

Protein
Submitted name:

Phosphodiesterase 4C, cAMP-specific, isoform CRA_b

Gene

Pde4c

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. 3',5'-cyclic-nucleotide phosphodiesterase activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. signal transduction Source: InterPro

    Keywords - Molecular functioni

    HydrolaseSAAS annotation

    Keywords - Ligandi

    Metal-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Phosphodiesterase 4C, cAMP-specific, isoform CRA_bImported
    Submitted name:
    cAMP-specific 3',5'-cyclic phosphodiesterase 4CImported
    Gene namesi
    Name:Pde4cImported
    Synonyms:Dpde1Imported
    ORF Names:rCG_38833Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 16

    Organism-specific databases

    RGDi727918. Pde4c.

    Subcellular locationi

    GO - Cellular componenti

    1. primary cilium Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00740000115148.
    KOiK13293.
    OMAiGENCDIF.
    OrthoDBiEOG7HQNBC.
    TreeFamiTF314638.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    InterProiIPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3V8J8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRSGTTLSF LLTERVREPV DSGVAPVSHL GGGVILRRFS GTLLLPPLSS    50
    RLGSSGEAES AAPVVFTIGS RGTERSHGSA QSSFDLENGL PSGRGPLDAQ 100
    SGSSLGRALQ PPVHHGQRRE SFLYRSDSDH EPSPKAVSRT SSAASDLHGE 150
    DMIVTPFAQV LASLRTVRSN VAALAHGAGS ATRQALLGTP PQSSQQAAPA 200
    EESGLQLAQE TLEELDWCLE QLETLQTRRS VGEMASNKFK RMLNRELTHL 250
    SETSRSGNQV SEYISQTFLD QQAEVELPAP PTEDHPWPMA QITGLRKSCH 300
    TSLPTAAIPR FGVQTDQEEQ LAKELEDTNK WGFDVFKVAE LSGNRPLTAV 350
    IFSVLQERDL LKTFQIPADT LLRYLLTLEG HYHSNVAYHN SIHAADVVQS 400
    AHVLLGTPAL EAVFTDLEVL AAIFACAIHD VDHPGVSNQF LINTNSELAL 450
    MYNDSSVLEN HHLAVGFKLL QGENCDIFQN LSTKQKLSLR RMVIDMVLAT 500
    DMSKHMSLLA DLKTMVETKK VTSLGVLLLD NYSDRIQVLQ SLVHCADLSN 550
    PAKPLPLYRQ WTERIMAEFF QQGDRERESG LDISPMCDKH TASVEKSQVG 600
    FIDYIAHPLW ETWADLVHPD AQELLDTLED NREWYQSRVP CSPPHAIGPD 650
    RFKFELTLEE TEEEEEEDER H 671
    Length:671
    Mass (Da):74,238
    Last modified:November 16, 2011 - v1
    Checksum:i0ED8A4FB34962FA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06086857 Genomic DNA. No translation available.
    CH474031 Genomic DNA. Translation: EDL90730.1.
    RefSeqiNP_001263694.1. NM_001276765.1.
    XP_006252930.1. XM_006252868.1.
    UniGeneiRn.214181.
    Rn.92465.

    Genome annotation databases

    EnsembliENSRNOT00000026457; ENSRNOP00000026457; ENSRNOG00000019518.
    GeneIDi290646.
    KEGGirno:290646.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06086857 Genomic DNA. No translation available.
    CH474031 Genomic DNA. Translation: EDL90730.1 .
    RefSeqi NP_001263694.1. NM_001276765.1.
    XP_006252930.1. XM_006252868.1.
    UniGenei Rn.214181.
    Rn.92465.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026457 ; ENSRNOP00000026457 ; ENSRNOG00000019518 .
    GeneIDi 290646.
    KEGGi rno:290646.

    Organism-specific databases

    CTDi 5143.
    RGDi 727918. Pde4c.

    Phylogenomic databases

    GeneTreei ENSGT00740000115148.
    KOi K13293.
    OMAi GENCDIF.
    OrthoDBi EOG7HQNBC.
    TreeFami TF314638.

    Miscellaneous databases

    NextBioi 631402.
    PROi G3V8J8.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    InterProi IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V8J8_RAT
    AccessioniPrimary (citable) accession number: G3V8J8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3