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G3V852

- G3V852_RAT

UniProt

G3V852 - G3V852_RAT

Protein
Submitted name:

Protein Tln1

Gene

Tln1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. integrin binding Source: RGD
    2. protein complex binding Source: RGD
    3. structural constituent of cytoskeleton Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: InterPro
    2. cell-substrate junction assembly Source: Ensembl
    3. cortical actin cytoskeleton organization Source: Ensembl
    4. cytoskeletal anchoring at plasma membrane Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_224772. Smooth Muscle Contraction.
    REACT_93415. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Tln1Imported
    Submitted name:
    RCG55135, isoform CRA_bImported
    Gene namesi
    Name:Tln1Imported
    ORF Names:rCG_55135Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi1306247. Tln1.

    Subcellular locationi

    GO - Cellular componenti

    1. actin cytoskeleton Source: InterPro
    2. centrosome Source: Ensembl
    3. extracellular vesicular exosome Source: Ensembl
    4. focal adhesion Source: Ensembl
    5. intracellular membrane-bounded organelle Source: Ensembl
    6. plasma membrane Source: Ensembl
    7. ruffle Source: InterPro

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00550000074542.
    KOiK06271.
    OMAiGAHIKHR.
    OrthoDBiEOG7TBC1J.
    TreeFamiTF314677.

    Family and domain databases

    Gene3Di1.20.1410.10. 3 hits.
    1.20.1420.10. 1 hit.
    1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR002558. ILWEQ_dom.
    IPR002404. Insln_rcpt_S1.
    IPR011993. PH_like_dom.
    IPR015710. Talin-1.
    IPR015224. Talin_cent.
    IPR029071. Ubiquitin-rel_dom.
    IPR015009. Vinculin-bd_dom.
    IPR006077. Vinculin/catenin.
    [Graphical view]
    PANTHERiPTHR19981:SF7. PTHR19981:SF7. 1 hit.
    PfamiPF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF01608. I_LWEQ. 1 hit.
    PF02174. IRS. 1 hit.
    PF09141. Talin_middle. 1 hit.
    PF08913. VBS. 2 hits.
    [Graphical view]
    ProDomiPD011820. ILWEQ. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00295. B41. 1 hit.
    SM00307. ILWEQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF109880. SSF109880. 1 hit.
    SSF109885. SSF109885. 4 hits.
    SSF47031. SSF47031. 1 hit.
    SSF47220. SSF47220. 5 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50945. I_LWEQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3V852-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVALSLRISI GNVVKTMQFE PSTMVYDACR MIRERIPEAL AGPPSDFGLF     50
    LSDDDPKKGI WLEAGKALDY YMLRNGDTME YRKKQRPLKI RMLDGTVKTI 100
    MVDDSKTVTD MLMTICARIG ITNHDEYSLV RELMEEKKDE GTGTLRKDKT 150
    LLRDEKKMEK LKQKLHTDDE LNWLDHGRTL REQGVEEHET LLLRRKFFYS 200
    DQNVDSRDPV QLNLLYVQAR DDILNGSHPV SFDKACEFAG FQCQIQFGPH 250
    NEQKHKAGFL DLKDFLPKEY VKQKGERKIF QAHKNCGQMS EIEAKVRYVK 300
    LARSLKTYGV SFFLVKEKMK GKNKLVPRLL GITKECVMRV DEKTKEVIQE 350
    WSLTNIKRWA ASPKSFTLDF GDYQDGYYSV QTTEGEQIAQ LIAGYIDIIL 400
    KKKKSKDHFG LEGDEESTML EDSVSPKKST VLQQQYNRVG KAEHGSVALP 450
    AIMRSGASGP ENFQVGSMPP AQQQVTSGQM HRGHMPPLTS AQQALTGTIN 500
    SSMQAVQAAQ AALDDFDALP PLGQDAASKA WRKNKMDESK HEIHSQVDAI 550
    TAGTASVVNL TAGDPAETDY TAVGCAVTTI SSNLTEMSRG VKLLAALLED 600
    EGGNGRPLLQ AAKGLAGAVS ELLRSAQPAS AEPRQNLLQA AGNVGQASGE 650
    LLQQIGESDT DPHFQDILMQ LAKAVASAAA ALVLKAKSVA QRTEDSGLQT 700
    QVIAAATQCA LSTSQLVACT KVVAPTISSP VCQEQLVEAG RLVAKAVEGC 750
    VSASQAATED GQLLRGVGAA ATAVTQALNE LLQHVKAHAT GAGPAGRYDQ 800
    ATDTILTVTE NIFSSMGDAG EMVRQARILA QATSDLVNAI KADAEGESDL 850
    ENSRKLLSAA KILADATAKM VEAAKGAAAH PDSEEQQQRL REAAEGLRMA 900
    TNAAAQNAIK KKLVQRLEHA AKQAAASATQ TIAAAQHAAS APKASAGPQP 950
    LLVQSCKAVA EQIPLLVQGV RGSQAQPDSP SAQLALIAAS QSFLQPGGKM 1000
    VAAAKASVPT IQDQASAMQL SQCAKNLGTA LAELRTAAQK AQEACGPLEM 1050
    DSALSVVQNL EKDLQEIKAA AREGKLKPLP GETMEKCTQD LGNSTKAVSS 1100
    AIAKLLGEIA QGNENYAGIA ARDVAGGLRS LAQAARGVAA LTTDPAVQAI 1150
    VLDTASDALD KASSLIEEAK KASGHPGDPE SQQRLAQVAK AVTQALNRCV 1200
    SCLPGQRDVD NALRAVGDAS KRLLSDSLPP STGTFQEAQS RLNEAAAGLN 1250
    QAATELVQAS RGTPQDLARA SGRFGQDFST FLEAGVEMAG QAPSQEDRAQ 1300
    VVSNLKGISM SSSKLLLAAK ALSTDPAAPN LKSQLAAAAR AVTDSINQLI 1350
    TMCTQQAPGQ KECDNALRQL ETVRELLENP VQPINDMSYF GCLDSVMENS 1400
    KVLGEAMTGI SQNAKNGNLP EFGDAIATAS KALCGFTEAA AQAAYLVGVS 1450
    DPNSQAGQQG LVEPTQFARA NQAIQMACQS LGEPGCTQAQ VLSAATIVAK 1500
    HTSALCNSCR LASARTANPT AKRQFVQSAK EVANSTANLV KTIKALDGAF 1550
    TEENRAQCRA ATAPLLEAVD NLSAFASNPE FSSVPAQISP EGRAAMEPIV 1600
    ISAKTMLESA GGLIQTARAL AVNPRDPPRW SVLAGHSRTV SDSIKKLITS 1650
    MRDKAPGQLE CETAIAALNS CLRDLDQASL AAVSQQLAPR EGISQEALHT 1700
    QMLTAVQEIS HLIEPLASAA RAEASQLGHK VSQMAQYFEP LTLAAVGAAS 1750
    KTLSHPQQMA LLDQTKTLAE SALQLLYTAK EAGGNPKQAA HTQEALEEAV 1800
    QMMTEAVEDL TTTLNEAASA AGVVGGMVDS ITQAINQLDE GPMGEPEGSF 1850
    VDYQTTMVRT AKAIAVTVQE MVTKSNTSPE ELGPLANQLT SDYGRLASQA 1900
    KPAAVAAENE EIGAHIKHRV QELGHGCSAL VTKAGALQCS PSDVYTKKEL 1950
    IECARRVSEK VSHVLAALQA GNRGTQACIT AASAVSGIIA DLDTTIMFAT 2000
    AGTLNREGAE TFADHREGIL KTAKVLVEDT KVLVQNAAGS QEKLAQAAQS 2050
    SVATITRLAD VVKLGAASLG AEDPETQVVL INAVKDVAKA LGDLISATKA 2100
    AAGKVGDDPA VWQLKNSAKV MVTNVTSLLK TVKAVEDEAT KGTRALEATT 2150
    EHIRQELAVF CSPEPPAKTS TPEDFIRMTK GITMATAKAV AAGNSCRQED 2200
    VIATANLSRR AIADMLRACK EAAFHPEVAP DVRLRALHFG RECANGYLEL 2250
    LDHVLLTLQK PNPELKQQLT GHSKRVAGSV TELIQAAEAM KGTEWVDPED 2300
    PTVIAENELL GAAAAIEAAA KKLEQLKPRA KPKEADESLN FEEQILEAAK 2350
    SIAAATSALV KAASAAQREL VAQGKVGAIP ANALDDGQWS QGLISAARMV 2400
    AAATNNLCEA ANAAVQGHAS QEKLISSAKQ VAASTAQLLV ACKVKADQDS 2450
    EAMKRLQAAG NAVKRASDNL VKAAQKAAAF EDQENETVVV KEKMVGGIAQ 2500
    IIAAQEEMLR KERELEEARK KLAQIRQQQY KFLPSELRDE H 2541
    Length:2,541
    Mass (Da):269,672
    Last modified:November 16, 2011 - v1
    Checksum:i755E0BB7E7FBE5DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06036784 Genomic DNA. No translation available.
    CH473962 Genomic DNA. Translation: EDL98752.1.
    RefSeqiNP_001034114.2. NM_001039025.2.
    UniGeneiRn.7715.

    Genome annotation databases

    EnsembliENSRNOT00000022400; ENSRNOP00000022401; ENSRNOG00000016630.
    GeneIDi313494.
    KEGGirno:313494.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06036784 Genomic DNA. No translation available.
    CH473962 Genomic DNA. Translation: EDL98752.1 .
    RefSeqi NP_001034114.2. NM_001039025.2.
    UniGenei Rn.7715.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022400 ; ENSRNOP00000022401 ; ENSRNOG00000016630 .
    GeneIDi 313494.
    KEGGi rno:313494.

    Organism-specific databases

    CTDi 7094.
    RGDi 1306247. Tln1.

    Phylogenomic databases

    GeneTreei ENSGT00550000074542.
    KOi K06271.
    OMAi GAHIKHR.
    OrthoDBi EOG7TBC1J.
    TreeFami TF314677.

    Enzyme and pathway databases

    Reactomei REACT_224772. Smooth Muscle Contraction.
    REACT_93415. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    NextBioi 666267.
    PROi G3V852.

    Family and domain databases

    Gene3Di 1.20.1410.10. 3 hits.
    1.20.1420.10. 1 hit.
    1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR002558. ILWEQ_dom.
    IPR002404. Insln_rcpt_S1.
    IPR011993. PH_like_dom.
    IPR015710. Talin-1.
    IPR015224. Talin_cent.
    IPR029071. Ubiquitin-rel_dom.
    IPR015009. Vinculin-bd_dom.
    IPR006077. Vinculin/catenin.
    [Graphical view ]
    PANTHERi PTHR19981:SF7. PTHR19981:SF7. 1 hit.
    Pfami PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF01608. I_LWEQ. 1 hit.
    PF02174. IRS. 1 hit.
    PF09141. Talin_middle. 1 hit.
    PF08913. VBS. 2 hits.
    [Graphical view ]
    ProDomi PD011820. ILWEQ. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00295. B41. 1 hit.
    SM00307. ILWEQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109880. SSF109880. 1 hit.
    SSF109885. SSF109885. 4 hits.
    SSF47031. SSF47031. 1 hit.
    SSF47220. SSF47220. 5 hits.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS50945. I_LWEQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V852_RAT
    AccessioniPrimary (citable) accession number: G3V852
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3