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G3V843

- G3V843_RAT

UniProt

G3V843 - G3V843_RAT

Protein

Prothrombin

Gene

F2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.UniRule annotation

    Catalytic activityi

    Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.UniRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. serine-type endopeptidase activity Source: Ensembl
    3. thrombospondin receptor activity Source: Ensembl

    GO - Biological processi

    1. acute-phase response Source: UniProtKB-KW
    2. cell surface receptor signaling pathway Source: Ensembl
    3. cytosolic calcium ion homeostasis Source: Ensembl
    4. fibrinolysis Source: Ensembl
    5. negative regulation of astrocyte differentiation Source: Ensembl
    6. negative regulation of proteolysis Source: Ensembl
    7. platelet activation Source: Ensembl
    8. positive regulation of blood coagulation Source: Ensembl
    9. positive regulation of cell growth Source: Ensembl
    10. positive regulation of cell proliferation Source: Ensembl
    11. positive regulation of collagen biosynthetic process Source: Ensembl
    12. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    13. positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    14. positive regulation of protein phosphorylation Source: Ensembl
    15. positive regulation of reactive oxygen species metabolic process Source: Ensembl
    16. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
    17. regulation of cell shape Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Acute phaseUniRule annotation, Blood coagulationUniRule annotation, Hemostasis

    Keywords - Ligandi

    CalciumSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ProthrombinUniRule annotation (EC:3.4.21.5UniRule annotation)
    Alternative name(s):
    Coagulation factor IIUniRule annotation
    Gene namesi
    Name:F2Imported
    ORF Names:rCG_27251Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi61996. F2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S1 family.UniRule annotation
    Contains Gla (gamma-carboxy-glutamate) domain.SAAS annotation
    Contains peptidase S1 domain.SAAS annotation
    Contains peptidase Sdomain.SAAS annotation

    Keywords - Domaini

    KringleSAAS annotation, RepeatSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117249.
    KOiK01313.
    OMAiGIECQLW.
    OrthoDBiEOG767394.
    TreeFamiTF327329.

    Family and domain databases

    Gene3Di2.40.20.10. 2 hits.
    4.10.140.10. 1 hit.
    4.10.740.10. 1 hit.
    InterProiIPR017857. Coagulation_fac_subgr_Gla_dom.
    IPR000294. GLA_domain.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR003966. Prothrombin/thrombin.
    IPR018992. Thrombin_light_chain.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00594. Gla. 1 hit.
    PF00051. Kringle. 2 hits.
    PF09396. Thrombin_light. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001149. Thrombin. 1 hit.
    PRINTSiPR00722. CHYMOTRYPSIN.
    PR00001. GLABLOOD.
    PR01505. PROTHROMBIN.
    SMARTiSM00069. GLA. 1 hit.
    SM00130. KR. 2 hits.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF57440. SSF57440. 2 hits.
    SSF57630. SSF57630. 1 hit.
    PROSITEiPS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    PS00021. KRINGLE_1. 2 hits.
    PS50070. KRINGLE_2. 2 hits.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3V843-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHVRGLGLP GCLALAALAS LVHSQHVFLA PQQALSLLQR VRRANSGFLE    50
    ELRKGNLERE CVEEQCSYEE AFEALESPQD TDVFWAKYTV CDSVRKPRET 100
    FMDCLEGRCA MDLGLNYHGN VSVTHTGIEC QLWRSRYPHR PDINSTTHPG 150
    ADLKENFCRN PDSSTSGPWC YTTDPTVRRE ECSIPVCGQE GRTTVKMTPR 200
    SRGSKENLSP PLGECLLERG RLYQGNLAVT TLGSPCLAWD SLPTKTLSKY 250
    QNFDPEVKLV QNFCRNPDRD EEGAWCFVAQ QPGFEYCSLN YCDEAVGEEN 300
    HDGDESIAGR TTDAEFHTFF DERTFGLGEA DCGLRPLFEK KSLTDKTEKE 350
    LLDSYIDGRI VEGWDAEKGI APWQVMLFRK SPQELLCGAS LISDRWVLTA 400
    AHCILYPPWD KNFTENDLLV RIGKHSRTRY ERNVEKISML EKIYIHPRYN 450
    WRENLDRDIA LLKLKKPVPF SDYIHPVCLP DKQTVTSLLQ AGYKGRVTGW 500
    GNLRETWTTN INEIQPSVLQ VVNLPIVERP VCKASTRIRI TDNMFCAGFK 550
    VNDTKRGDAC EGDSGGPFVM KSPYNHRWYQ MGIVSWGEGC DRNGKYGFYT 600
    HVFRLKRWMQ KVIDQHR 617
    Length:617
    Mass (Da):70,386
    Last modified:November 16, 2011 - v1
    Checksum:i8C11117828B20AC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06024739 Genomic DNA. No translation available.
    CH473949 Genomic DNA. Translation: EDL79531.1.
    RefSeqiNP_075213.2. NM_022924.2.
    UniGeneiRn.54498.

    Genome annotation databases

    EnsembliENSRNOT00000022233; ENSRNOP00000022233; ENSRNOG00000016325.
    GeneIDi29251.
    KEGGirno:29251.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06024739 Genomic DNA. No translation available.
    CH473949 Genomic DNA. Translation: EDL79531.1 .
    RefSeqi NP_075213.2. NM_022924.2.
    UniGenei Rn.54498.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022233 ; ENSRNOP00000022233 ; ENSRNOG00000016325 .
    GeneIDi 29251.
    KEGGi rno:29251.

    Organism-specific databases

    CTDi 2147.
    RGDi 61996. F2.

    Phylogenomic databases

    GeneTreei ENSGT00750000117249.
    KOi K01313.
    OMAi GIECQLW.
    OrthoDBi EOG767394.
    TreeFami TF327329.

    Miscellaneous databases

    NextBioi 608542.
    PROi G3V843.

    Family and domain databases

    Gene3Di 2.40.20.10. 2 hits.
    4.10.140.10. 1 hit.
    4.10.740.10. 1 hit.
    InterProi IPR017857. Coagulation_fac_subgr_Gla_dom.
    IPR000294. GLA_domain.
    IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR003966. Prothrombin/thrombin.
    IPR018992. Thrombin_light_chain.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00594. Gla. 1 hit.
    PF00051. Kringle. 2 hits.
    PF09396. Thrombin_light. 1 hit.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001149. Thrombin. 1 hit.
    PRINTSi PR00722. CHYMOTRYPSIN.
    PR00001. GLABLOOD.
    PR01505. PROTHROMBIN.
    SMARTi SM00069. GLA. 1 hit.
    SM00130. KR. 2 hits.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF57440. SSF57440. 2 hits.
    SSF57630. SSF57630. 1 hit.
    PROSITEi PS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    PS00021. KRINGLE_1. 2 hits.
    PS50070. KRINGLE_2. 2 hits.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V843_RAT
    AccessioniPrimary (citable) accession number: G3V843
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3