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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 8

Gene

Map3k8

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-389357. CD28 dependent PI3K/Akt signaling.
R-RNO-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 8Imported
Gene namesi
Name:Map3k8Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi620969. Map3k8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiG3V840.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016378.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022190.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini236 – 486251Protein kinaseInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0201. Eukaryota.
ENOG410XP9G. LUCA.
GeneTreeiENSGT00800000124036.
OMAiIHLFMEA.
OrthoDBiEOG091G0682.
TreeFamiTF105117.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGGSHSETE RASHQGTLGW PAARRYSWKA PCSGPREVWT RGSSPFLLLP
60 70 80 90 100
GFRVTSQCRS GLRWWTGAHA LTASPAGDAA WTAAFWLLSL DSPAGTTVME
110 120 130 140 150
YMSTGSDEKE EIDLLINHLN VSEVLDIMEN LYASEEPAVY EPSLMTMCPD
160 170 180 190 200
SNQNKEHSES LLRSGQEVPW LSSVRYGTVE DLLAFANHIS NTTKHFYGCR
210 220 230 240 250
PQESGILLNM VISPQNGRYQ IDSDVLLVPW KLTYRSIGSG FVPRGAFGKV
260 270 280 290 300
YLAQDMKTKK RMACKLIPVD QFKPSDVEIQ ACFRHENIAE LYGAVLWGDT
310 320 330 340 350
VHLFMEAGEG GSVLEKLESC GPMREFEIIW VTKHVLKGLD FLHSKKVIHH
360 370 380 390 400
DIKPSNIVFM STKAVLVDFG LSVQMTEDVY LPKDLRGTEI YMSPEVILCR
410 420 430 440 450
GHSTKADIYS LGATLIHMQT GTPPWVKRYP RSAYPSYLYI IHKQAPPLED
460 470 480 490 500
IAGDCSPGMR ELIEAALERN PNHRPKAADL LKHEALNPPR EDQPRCQSLD
510 520 530 540 550
SALFDRKRLL SRKELELPEN IADSSCTGST EESEVLRRQR SLYIDLGALA
560
GYFNIVRGPP TLEYG
Length:565
Mass (Da):63,216
Last modified:July 22, 2015 - v2
Checksum:i69FD16D82E64748D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07028081 Genomic DNA. No translation available.
RefSeqiXP_006254110.1. XM_006254048.2.
UniGeneiRn.9939.

Genome annotation databases

EnsembliENSRNOT00000022190; ENSRNOP00000022190; ENSRNOG00000016378.
GeneIDi116596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07028081 Genomic DNA. No translation available.
RefSeqiXP_006254110.1. XM_006254048.2.
UniGeneiRn.9939.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022190.

Proteomic databases

PaxDbiG3V840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022190; ENSRNOP00000022190; ENSRNOG00000016378.
GeneIDi116596.

Organism-specific databases

CTDi1326.
RGDi620969. Map3k8.

Phylogenomic databases

eggNOGiKOG0201. Eukaryota.
ENOG410XP9G. LUCA.
GeneTreeiENSGT00800000124036.
OMAiIHLFMEA.
OrthoDBiEOG091G0682.
TreeFamiTF105117.

Enzyme and pathway databases

ReactomeiR-RNO-389357. CD28 dependent PI3K/Akt signaling.
R-RNO-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.

Gene expression databases

BgeeiENSRNOG00000016378.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG3V840_RAT
AccessioniPrimary (citable) accession number: G3V840
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: July 22, 2015
Last modified: September 7, 2016
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.