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Protein

Transketolase

Gene

Tkt

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.UniRule annotation

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Ca2+UniRule annotation, Mn2+UniRule annotation, Co2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.UniRule annotation
  • thiamine diphosphateUniRule annotationNote: Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Ligandi

CalciumUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Thiamine pyrophosphateUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-163754. Insulin effects increased synthesis of Xylulose-5-Phosphate.
R-RNO-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Names & Taxonomyi

Protein namesi
Recommended name:
TransketolaseUniRule annotation (EC:2.2.1.1UniRule annotation)
Gene namesi
Name:TktImported
ORF Names:rCG_42377Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi621036. Tkt.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSRNOG00000016064.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021862.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 75TRANSKETOLASE_1InterPro annotationAdd BLAST21

Sequence similaritiesi

Belongs to the transketolase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0523. Eukaryota.
COG0021. LUCA.
GeneTreeiENSGT00390000005240.
OMAiKAFGQAR.
OrthoDBiEOG091G03M5.
TreeFamiTF313097.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR033248. Transketolase_C.
IPR033247. Transketolase_fam.
IPR005474. Transketolase_N.
[Graphical view]
PANTHERiPTHR11624. PTHR11624. 1 hit.
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
PF00456. Transketolase_N. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPVRQIQCD REGKRFPFLS APPASTSSPD RAMEGYHKPD QQKLQALKDT
60 70 80 90 100
ANRLRISSIQ ATTAAGSGHP TSCCSAAEIM AVLFFHTMRY KALDPRNPHN
110 120 130 140 150
DRFVLSKGHA APILYAVWAE AGFLPEAELL NLRKISSDLD GHPVPKQAFT
160 170 180 190 200
DVATGSLGQG LGAACGMAYT GKYFDKASYR VYCMLGDGEV SEGSVWEAMA
210 220 230 240 250
FAGIYKLDNL VAIFDINRLG QSDPAPLQHQ VDVYQKRCEA FGWHAIIVDG
260 270 280 290 300
HSVEELCKAF GQAKHQPTAI IAKTFKGRGI TGIEDKEAWH GKPLPKNMAE
310 320 330 340 350
QIIQEIYSQV QSKKKILATP PQEDAPSVDI ANIRMPTPPN YKVGDKIATR
360 370 380 390 400
KAYGLALAKL GHASDRIIAL DGDTKNSTFS ELFKKEHPDR FIECYIAEQN
410 420 430 440 450
MVSIAVGCAT RDRTVPFCST FAAFFTRAFD QIRMAAISES NINLCGSHCG
460 470 480 490 500
VSIGEDGPSQ MALEDLAMFR SVPMSTVFYP SDGVATEKAV ELAANTKGIC
510 520 530 540 550
FIRTSRPENA IIYSNNEDFQ VGQAKVVLKS KDDQVTVIGA GVTLHEALAA
560 570 580 590 600
AEMLKKEKIG VRVLDPFTIK PLDKKLILDC ARATKGRILT VEDHYYEGGI
610 620 630 640 650
GEAVSAAVVG EPGVTVTRLA VSQVPRSGKP AELLKMFGID KDAIVQAVKG

LVTKG
Length:655
Mass (Da):71,159
Last modified:November 16, 2011 - v1
Checksum:i879FF8EFF616343F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07024579 Genomic DNA. No translation available.
CH474046 Genomic DNA. Translation: EDL88991.1.
UniGeneiRn.5950.

Genome annotation databases

EnsembliENSRNOT00000021862; ENSRNOP00000021862; ENSRNOG00000016064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07024579 Genomic DNA. No translation available.
CH474046 Genomic DNA. Translation: EDL88991.1.
UniGeneiRn.5950.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021862.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021862; ENSRNOP00000021862; ENSRNOG00000016064.

Organism-specific databases

RGDi621036. Tkt.

Phylogenomic databases

eggNOGiKOG0523. Eukaryota.
COG0021. LUCA.
GeneTreeiENSGT00390000005240.
OMAiKAFGQAR.
OrthoDBiEOG091G03M5.
TreeFamiTF313097.

Enzyme and pathway databases

ReactomeiR-RNO-163754. Insulin effects increased synthesis of Xylulose-5-Phosphate.
R-RNO-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Gene expression databases

BgeeiENSRNOG00000016064.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR033248. Transketolase_C.
IPR033247. Transketolase_fam.
IPR005474. Transketolase_N.
[Graphical view]
PANTHERiPTHR11624. PTHR11624. 1 hit.
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
PF00456. Transketolase_N. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG3V826_RAT
AccessioniPrimary (citable) accession number: G3V826
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 30, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.