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Protein

Cytochrome P450 26B1

Gene

Cyp26b1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (By similarity).By similarity
Has also a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi441Iron (heme axial ligand)Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-211916 Vitamins
R-RNO-5365859 RA biosynthesis pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 26B1 (EC:1.14.13.-By similarity)
Gene namesi
Name:Cyp26b1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi631379 Cyp26b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004169061 – 512Cytochrome P450 26B1Add BLAST512

Proteomic databases

PaxDbiG3V7X8
PRIDEiG3V7X8

PTM databases

iPTMnetiG3V7X8
PhosphoSitePlusiG3V7X8

Expressioni

Gene expression databases

BgeeiENSRNOG00000015076
GenevisibleiG3V7X8 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020505

Structurei

3D structure databases

ProteinModelPortaliG3V7X8
SMRiG3V7X8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00800000124060
HOGENOMiHOG000220829
InParanoidiG3V7X8
KOiK12664
OMAiKEGRFHY
OrthoDBiEOG091G0K6Z
PhylomeDBiG3V7X8
TreeFamiTF105093

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002403 Cyt_P450_E_grp-IV
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00465 EP450IV
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

G3V7X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFEGLELVS ALATLAACLV SVTLLLAVSQ QLWQLRWAAT RDKSCKLPIP
60 70 80 90 100
KGSMGFPLIG ETGHWLLQGS GFQSSRREKY GNVFKTHLLG RPLIRVTGAE
110 120 130 140 150
NVRKILLGEH QLVSTEWPRS ARVLLGPNTV ANSIGDIHRN KRKVFSKIFS
160 170 180 190 200
HEALESYLPK IQLVIQDTLR AWSSQPEAIN VYQEAQRLTF RMAVRVLLGF
210 220 230 240 250
SIPEEDLGNL FEVYQQFVEN VFSLPVDLPF SGYRRGIQAR QILQKGLEKA
260 270 280 290 300
IREKLQCTQG KDYSDALDIL IESSKEHGKE MTMQELKDGT LELIFAAYAT
310 320 330 340 350
TASASTSLIM QLLKHPAVLE KLREELRAQG LLHGGGCPCE GTLRLDMLSG
360 370 380 390 400
LRYLDCVIKE VMRLFTPVSG GYRTVLQTFE LDGFQIPKGW SVMYSIRDTH
410 420 430 440 450
DTAPVFKDVN VFDPDRFSQA RSEDKDGRFH YLPFGGGVRT CLGKHLAKLF
460 470 480 490 500
LKVLAVELAS TSRFELATRT FPRITLVPVL HPVDGLSVKF FGLDSNQNEI
510
LPETEAMLSA TV
Length:512
Mass (Da):57,352
Last modified:November 16, 2011 - v1
Checksum:iF346AB0F302E4CE7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251I → V in AAO92253 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY245532 mRNA Translation: AAO92253.1
CH473957 Genomic DNA Translation: EDL91177.1
RefSeqiNP_851601.1, NM_181087.2
UniGeneiRn.19898

Genome annotation databases

EnsembliENSRNOT00000020505; ENSRNOP00000020505; ENSRNOG00000015076
GeneIDi312495
KEGGirno:312495

Similar proteinsi

Entry informationi

Entry nameiCP26B_RAT
AccessioniPrimary (citable) accession number: G3V7X8
Secondary accession number(s): Q80YE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: November 16, 2011
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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