Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

G3V7V7

- G3V7V7_RAT

UniProt

G3V7V7 - G3V7V7_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Insulin receptor substrate 1

Gene

Irs1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Biological processi

  1. insulin-like growth factor receptor signaling pathway Source: Ensembl
  2. insulin receptor signaling pathway Source: Ensembl
  3. lipid catabolic process Source: Ensembl
  4. mammary gland development Source: Ensembl
  5. negative regulation of insulin secretion Source: Ensembl
  6. phosphatidylinositol 3-kinase signaling Source: Ensembl
  7. positive regulation of cell migration Source: Ensembl
  8. positive regulation of fatty acid beta-oxidation Source: Ensembl
  9. positive regulation of glucose import in response to insulin stimulus Source: Ensembl
  10. positive regulation of glycogen biosynthetic process Source: Ensembl
  11. positive regulation of mesenchymal cell proliferation Source: Ensembl
  12. positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl
  13. protein kinase B signaling Source: Ensembl
  14. protein localization to nucleus Source: Ensembl
  15. regulation of gene expression Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiREACT_195204. Signaling by Leptin.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_202337. IRS activation.
REACT_204559. SOS-mediated signalling.
REACT_212872. Signal attenuation.
REACT_222757. IRS-related events triggered by IGF1R.
REACT_246902. PI3K/AKT activation.
REACT_256279. PI3K Cascade.
REACT_257653. PIP3 activates AKT signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin receptor substrate 1Imported
Gene namesi
Name:Irs1Imported
ORF Names:rCG_24010Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi2922. Irs1.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. ciliary basal body Source: Ensembl
  3. cytoplasm Source: Ensembl
  4. nucleus Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063420.
OMAiEYTEMMP.
OrthoDBiEOG7XM2X6.
TreeFamiTF325994.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00628. INSULINRSI.
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
PROSITEiPS51064. IRS_PTB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V7V7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASPPDTDGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE
60 70 80 90 100
KKWRHKSSAP KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE
110 120 130 140 150
AEQDSWYQAL LQLHNRAKAH HDGAGGGCGG SCSGSSGVGE AGEDLSYDTG
160 170 180 190 200
PGPAFKEVWQ VILKPKGLGQ TKNLIGIYRL CLTSKTISFV KLNSEAAAVV
210 220 230 240 250
LQLMNIRRCG HSENFFFIEV GRSAVTGPGE FWMQVDDSVV AQNMHETILE
260 270 280 290 300
AMRAMSDEFR PRSKSQSSSS CSNPISVPLR RHHLNNPPPS QVGLTRRSRT
310 320 330 340 350
ESITATSPAS MVGGKPGSFR VRASSDGEGT MSRPASVDGS PVSPSTNRTH
360 370 380 390 400
AHRHRGSSRL HPPLNHSRSI PMPSSRCSPS ATSPVSLSSS STSGHGSTSD
410 420 430 440 450
CLFPRRSSAS VSGSPSDGGF ISSDEYGSSP CDFRSSFRSV TPDSLGHTPP
460 470 480 490 500
ARGEEELSNY ICMGGKGAST LTAPNGHYIL SRGGNGHRYI PGATMGTSPA
510 520 530 540 550
LTGDEAAGAA DLDNRFRKRT HSAGTSPTIS HQKTPSQSSV VSIEEYTEMM
560 570 580 590 600
PAAYPPGGGS GGRLPGYRHS AFVPTHSYPE EGLEMHHLER RGGHHRPDSS
610 620 630 640 650
NLHTDDGYMP MSPGVAPVPS NRKGNGDYMP MSPKSVSAPQ QIINPIRRHP
660 670 680 690 700
QRVDPNGYMM MSPSGSCSPD IGGGSCSSSS ISAAPSGSSY GKPWTNGVGG
710 720 730 740 750
HHTHALPHAK PPVESGGGKL LPCTGDYMNM SPVGDSNTSS PSECYYGPED
760 770 780 790 800
PQHKPVLSYY SLPRSFKHTQ RPGEPEEGAR HQHLRLSSSS GRLRYTATAE
810 820 830 840 850
DSSSSTSSDS LGGGYCGARP ESSVTHPHHH ALQPHLPRKV DTAAQTNSRL
860 870 880 890 900
ARPTRLSLGD PKASTLPRVR EQQQQQQQQQ QSSLHPPEPK SPGEYVNIEF
910 920 930 940 950
GSGQPGYLAG PATSRSSPSV RCLPQLHPAP REETGSEEYM NMDLGPGRRA
960 970 980 990 1000
TWQESGGVEL GRVGPAPPGA ASICRPTRSV PNSRGDYMTM QIGCPRQSYV
1010 1020 1030 1040 1050
DTSPVAPVSY ADMRTGIAAE KVSLPRTTGA APPPSSTASA SASVTPQGAA
1060 1070 1080 1090 1100
EQAAHSSLLG GPQGPGGMSA FTRVNLSPNH NQSAKVIRAD TQGCRRRHSS
1110 1120 1130 1140 1150
ETFSAPTRAG NTVSFGAGAA GGGSGGGSED VKRHSSASFE NVWLRPGDLG
1160 1170 1180 1190 1200
GASKESAPGY GAAGGLEKSL NYIDLDLVKD VKQHPQDCPS QQQSLPPPPP
1210 1220 1230
HQPLGSNEGS SPRRSSEDLS TYASINFQKQ PEDRQ
Length:1,235
Mass (Da):131,210
Last modified:November 16, 2011 - v1
Checksum:i5CAC859DE3264049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06061285 Genomic DNA. No translation available.
CH474004 Genomic DNA. Translation: EDL75502.1.
UniGeneiRn.10476.

Genome annotation databases

EnsembliENSRNOT00000019579; ENSRNOP00000019579; ENSRNOG00000014597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06061285 Genomic DNA. No translation available.
CH474004 Genomic DNA. Translation: EDL75502.1 .
UniGenei Rn.10476.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000019579 ; ENSRNOP00000019579 ; ENSRNOG00000014597 .

Organism-specific databases

RGDi 2922. Irs1.

Phylogenomic databases

GeneTreei ENSGT00530000063420.
OMAi EYTEMMP.
OrthoDBi EOG7XM2X6.
TreeFami TF325994.

Enzyme and pathway databases

Reactomei REACT_195204. Signaling by Leptin.
REACT_198729. Constitutive PI3K/AKT Signaling in Cancer.
REACT_202337. IRS activation.
REACT_204559. SOS-mediated signalling.
REACT_212872. Signal attenuation.
REACT_222757. IRS-related events triggered by IGF1R.
REACT_246902. PI3K/AKT activation.
REACT_256279. PI3K Cascade.
REACT_257653. PIP3 activates AKT signaling.

Miscellaneous databases

NextBioi 35584030.
PROi G3V7V7.

Family and domain databases

Gene3Di 2.30.29.30. 2 hits.
InterProi IPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view ]
PRINTSi PR00628. INSULINRSI.
SMARTi SM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view ]
PROSITEi PS51064. IRS_PTB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiG3V7V7_RAT
AccessioniPrimary (citable) accession number: G3V7V7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 26, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3