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Protein
Submitted name:

Complement C1s subcomponent

Gene

C1s

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi66Calcium 1UniRule annotation1
Metal bindingi74Calcium 1UniRule annotation1
Metal bindingi119Calcium 1UniRule annotation1
Metal bindingi121Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi137Calcium 2UniRule annotation1
Metal bindingi138Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi140Calcium 2UniRule annotation1
Metal bindingi155Calcium 2UniRule annotation1
Metal bindingi159Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi232Calcium 3UniRule annotation1
Metal bindingi242Calcium 3UniRule annotation1
Metal bindingi281Calcium 3UniRule annotation1
Active sitei481Charge relay systemUniRule annotation1
Active sitei535Charge relay systemUniRule annotation1
Active sitei637Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, ProteaseSAAS annotation

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-166663. Initial triggering of complement.
R-RNO-173623. Classical antibody-mediated complement activation.

Protein family/group databases

MEROPSiS01.193.

Names & Taxonomyi

Protein namesi
Submitted name:
Complement C1s subcomponentImported
Submitted name:
RCG29725, isoform CRA_bImported
Gene namesi
Name:C1sImported
ORF Names:rCG_29725Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi619983. C1s.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500876207222 – 694Sequence analysisAdd BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi71 ↔ 89UniRule annotation
Disulfide bondi141 ↔ 153UniRule annotation
Disulfide bondi149 ↔ 162UniRule annotation
Modified residuei155(3R)-3-hydroxyasparagineUniRule annotation1
Disulfide bondi164 ↔ 177UniRule annotation
Disulfide bondi181 ↔ 208UniRule annotation
Disulfide bondi300 ↔ 347UniRule annotation
Disulfide bondi327 ↔ 360UniRule annotation
Disulfide bondi365 ↔ 409UniRule annotation
Disulfide bondi392 ↔ 427UniRule annotation
Disulfide bondi431 ↔ 555Interchain (between heavy and light chains)UniRule annotation
Disulfide bondi601 ↔ 624UniRule annotation
Disulfide bondi633 ↔ 665UniRule annotation

Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation, HydroxylationUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000011971.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016330.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 136CUBInterPro annotationAdd BLAST128
Domaini181 – 296CUBInterPro annotationAdd BLAST116
Domaini298 – 362Sushi (CCP/SCR)InterPro annotationAdd BLAST65
Domaini363 – 429Sushi (CCP/SCR)InterPro annotationAdd BLAST67
Domaini444 – 686Peptidase S1InterPro annotationAdd BLAST243

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation
Contains 1 peptidase S1 domain.UniRule annotation

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118890.
OMAiFGPYCGN.
OrthoDBiEOG091G02DS.
TreeFamiTF330373.

Family and domain databases

CDDicd00033. CCP. 2 hits.
cd00041. CUB. 2 hits.
cd00190. Tryp_SPc. 1 hit.
Gene3Di2.60.120.290. 2 hits.
InterProiIPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024175. Pept_S1A_C1r/C1S/mannan-bd.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP_dom.
IPR001254. Trypsin_dom.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00084. Sushi. 2 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001155. C1r_C1s_MASP. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00032. CCP. 2 hits.
SM00042. CUB. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF50494. SSF50494. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS01180. CUB. 2 hits.
PS01187. EGF_CA. 1 hit.
PS50923. SUSHI. 2 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V7L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKSPEMWCF VFFSLLASFS AEPTMYGEIL SPNYPQAYPN EVVKTWDIEV
60 70 80 90 100
PEGFGIHLYF THLDMELSEN CAYDSVQIIS GGIEEERLCG QRTSKSPNSP
110 120 130 140 150
IVEEFQFPYN RLQVVFTSDF SNEERFTGFA AYYSAVDVNE CTDFTDVPCS
160 170 180 190 200
HFCNNFIGGY FCSCPPEYFL HDDMRTCGVN CSGDVFTALI GEIASPNYPN
210 220 230 240 250
PYPENSRCEY QIRLQEGFRL VLTIRREDFD VEPADSEGNC HDSLTFAAKN
260 270 280 290 300
QQFGPYCGNG FPGPLTIKTQ SNTLDIVFQT DLTGQNKGWK LRYHGDPIPC
310 320 330 340 350
PKEISANSIW EPEKAKYVFK DVVKITCVDG FEVVEGNVGS TSFYSTCQSN
360 370 380 390 400
GQWSNSRLEC QPVDCGVPEP IENGKVEDPE DTVFGSVIHY TCEEPYYYME
410 420 430 440 450
QEEGGEYHCA ANGSWVNDQL GVELPKCIPV CGVPTEPFKV QQRIFGGYST
460 470 480 490 500
KIQSFPWQVY FESPRGGGAL IDEYWVLTAA HVVEGNSDPV MYVGSTLLKI
510 520 530 540 550
ERLRNAQRLI TERVIIHPSW KQEDDLNTRT NFDNDIALVQ LKDPVKMGPT
560 570 580 590 600
VAPICLPETS SDYNPSEGDL GLISGWGRTE NRTNVIQLRG AKLPITSLEK
610 620 630 640 650
CQQVKVENPK ARSNDYVFTD NMICAGEKGV DSCEGDSGGA FALPVPNVKD
660 670 680 690
PKFYVAGLVS WGKKCGTYGI YTKVKNYVDW ILKTMQENSG PKKD
Length:694
Mass (Da):77,713
Last modified:November 16, 2011 - v1
Checksum:i455A9EE10C8CC12F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128967 Genomic DNA. No translation available.
AC129138 Genomic DNA. No translation available.
CH473964 Genomic DNA. Translation: EDM01952.1.

Genome annotation databases

EnsembliENSRNOT00000016330; ENSRNOP00000016330; ENSRNOG00000011971.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128967 Genomic DNA. No translation available.
AC129138 Genomic DNA. No translation available.
CH473964 Genomic DNA. Translation: EDM01952.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016330.

Protein family/group databases

MEROPSiS01.193.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016330; ENSRNOP00000016330; ENSRNOG00000011971.

Organism-specific databases

RGDi619983. C1s.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118890.
OMAiFGPYCGN.
OrthoDBiEOG091G02DS.
TreeFamiTF330373.

Enzyme and pathway databases

ReactomeiR-RNO-166663. Initial triggering of complement.
R-RNO-173623. Classical antibody-mediated complement activation.

Gene expression databases

BgeeiENSRNOG00000011971.

Family and domain databases

CDDicd00033. CCP. 2 hits.
cd00041. CUB. 2 hits.
cd00190. Tryp_SPc. 1 hit.
Gene3Di2.60.120.290. 2 hits.
InterProiIPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024175. Pept_S1A_C1r/C1S/mannan-bd.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP_dom.
IPR001254. Trypsin_dom.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00084. Sushi. 2 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001155. C1r_C1s_MASP. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00032. CCP. 2 hits.
SM00042. CUB. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF50494. SSF50494. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS01180. CUB. 2 hits.
PS01187. EGF_CA. 1 hit.
PS50923. SUSHI. 2 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG3V7L3_RAT
AccessioniPrimary (citable) accession number: G3V7L3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 30, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.