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Protein
Submitted name:

Complement C1s subcomponent

Gene

C1s

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, ProteaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-RNO-166663. Initial triggering of complement.
R-RNO-173623. Classical antibody-mediated complement activation.
R-RNO-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Submitted name:
Complement C1s subcomponentImported
Submitted name:
RCG29725, isoform CRA_bImported
Gene namesi
Name:C1sImported
ORF Names:rCG_29725Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi619983. C1s.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501049717422 – 694Sequence analysisAdd BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi181 ↔ 208PROSITE-ProRule annotation
Disulfide bondi240 ↔ 257PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000011971.
ExpressionAtlasiG3V7L3. baseline and differential.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 136CUBInterPro annotationAdd BLAST128
Domaini181 – 296CUBInterPro annotationAdd BLAST116
Domaini298 – 362Sushi (CCP/SCR)InterPro annotationAdd BLAST65
Domaini363 – 429Sushi (CCP/SCR)InterPro annotationAdd BLAST67
Domaini444 – 686Peptidase S1InterPro annotationAdd BLAST243

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, SushiPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118890.
OMAiFGPYCGN.
OrthoDBiEOG091G02DS.
TreeFamiTF330373.

Family and domain databases

CDDicd00033. CCP. 2 hits.
cd00041. CUB. 2 hits.
cd00190. Tryp_SPc. 1 hit.
Gene3Di2.60.120.290. 2 hits.
InterProiView protein in InterPro
IPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP_dom.
IPR001254. Trypsin_dom.
IPR033116. TRYPSIN_SER.
PfamiView protein in Pfam
PF00431. CUB. 2 hits.
PF00084. Sushi. 2 hits.
PF00089. Trypsin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00032. CCP. 2 hits.
SM00042. CUB. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF50494. SSF50494. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 1 hit.
PS01180. CUB. 2 hits.
PS01187. EGF_CA. 1 hit.
PS50923. SUSHI. 2 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

G3V7L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKSPEMWCF VFFSLLASFS AEPTMYGEIL SPNYPQAYPN EVVKTWDIEV
60 70 80 90 100
PEGFGIHLYF THLDMELSEN CAYDSVQIIS GGIEEERLCG QRTSKSPNSP
110 120 130 140 150
IVEEFQFPYN RLQVVFTSDF SNEERFTGFA AYYSAVDVNE CTDFTDVPCS
160 170 180 190 200
HFCNNFIGGY FCSCPPEYFL HDDMRTCGVN CSGDVFTALI GEIASPNYPN
210 220 230 240 250
PYPENSRCEY QIRLQEGFRL VLTIRREDFD VEPADSEGNC HDSLTFAAKN
260 270 280 290 300
QQFGPYCGNG FPGPLTIKTQ SNTLDIVFQT DLTGQNKGWK LRYHGDPIPC
310 320 330 340 350
PKEISANSIW EPEKAKYVFK DVVKITCVDG FEVVEGNVGS TSFYSTCQSN
360 370 380 390 400
GQWSNSRLEC QPVDCGVPEP IENGKVEDPE DTVFGSVIHY TCEEPYYYME
410 420 430 440 450
QEEGGEYHCA ANGSWVNDQL GVELPKCIPV CGVPTEPFKV QQRIFGGYST
460 470 480 490 500
KIQSFPWQVY FESPRGGGAL IDEYWVLTAA HVVEGNSDPV MYVGSTLLKI
510 520 530 540 550
ERLRNAQRLI TERVIIHPSW KQEDDLNTRT NFDNDIALVQ LKDPVKMGPT
560 570 580 590 600
VAPICLPETS SDYNPSEGDL GLISGWGRTE NRTNVIQLRG AKLPITSLEK
610 620 630 640 650
CQQVKVENPK ARSNDYVFTD NMICAGEKGV DSCEGDSGGA FALPVPNVKD
660 670 680 690
PKFYVAGLVS WGKKCGTYGI YTKVKNYVDW ILKTMQENSG PKKD
Length:694
Mass (Da):77,713
Last modified:November 16, 2011 - v1
Checksum:i455A9EE10C8CC12F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC128967 Genomic DNA. No translation available.
AC129138 Genomic DNA. No translation available.
CH473964 Genomic DNA. Translation: EDM01952.1.

Genome annotation databases

EnsembliENSRNOT00000016330; ENSRNOP00000016330; ENSRNOG00000011971.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiG3V7L3_RAT
AccessioniPrimary (citable) accession number: G3V7L3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: July 5, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported