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G3V7J2

- G3V7J2_RAT

UniProt

G3V7J2 - G3V7J2_RAT

Protein
Submitted name:

Interferon-inducible double-stranded RNA-dependent protein kinase activator A

Gene

Prkra

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cellular response to oxidative stress Source: Ensembl
    2. middle ear morphogenesis Source: Ensembl
    3. outer ear morphogenesis Source: Ensembl
    4. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
    5. production of siRNA involved in RNA interference Source: Ensembl
    6. protein phosphorylation Source: Ensembl
    7. skeletal system morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    KinaseImported, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_197453. Small interfering RNA (siRNA) biogenesis.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Interferon-inducible double-stranded RNA-dependent protein kinase activator AImported
    Submitted name:
    Protein kinase, interferon inducible double stranded RNA dependent activator, isoform CRA_bImported
    Gene namesi
    Name:PrkraImported
    ORF Names:rCG_27414Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi1306707. Prkra.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00730000110945.
    OMAiPVTVCHG.
    OrthoDBiEOG741Z2Q.
    TreeFamiTF315953.

    Family and domain databases

    Gene3Di3.30.160.20. 3 hits.
    InterProiIPR014720. dsRNA-bd_dom.
    [Graphical view]
    PfamiPF00035. dsrm. 2 hits.
    [Graphical view]
    SMARTiSM00358. DSRM. 3 hits.
    [Graphical view]
    PROSITEiPS50137. DS_RBD. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3V7J2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHSRHRAEA PPLQREDSGT FSLGKMITAK PGKTPIQVLH EYGMKTKNIP    50
    VYECERSDVQ VHVPTFTFRV TVGDITCTGE GTSKKLAKHR AAEAAINILK 100
    ANASICFAVP DPLMPDPSKQ PKNQLNPIGS LQELAIHHGW RLPEYTLSQE 150
    GGPAHKREYT TICRLESFME TGKGASKKQA KRNAAEKFLA KFSNISPENH 200
    ISLTNVVGHS LGCTWHSLRN SPGEKINLLK RSLLSLPNTD YIQLLSEIAK 250
    EQGFSITYLD IEELSANGQY QCLAELSTSP ITVCHGSGIS CGNAQSDAAH 300
    NALQYLKIIA ERK 313
    Length:313
    Mass (Da):34,385
    Last modified:November 16, 2011 - v1
    Checksum:i785F2F01D5BE8CCA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06024247 Genomic DNA. No translation available.
    CH473949 Genomic DNA. Translation: EDL79230.1.
    UniGeneiRn.3217.

    Genome annotation databases

    EnsembliENSRNOT00000015624; ENSRNOP00000015624; ENSRNOG00000011195.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06024247 Genomic DNA. No translation available.
    CH473949 Genomic DNA. Translation: EDL79230.1 .
    UniGenei Rn.3217.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015624 ; ENSRNOP00000015624 ; ENSRNOG00000011195 .

    Organism-specific databases

    RGDi 1306707. Prkra.

    Phylogenomic databases

    GeneTreei ENSGT00730000110945.
    OMAi PVTVCHG.
    OrthoDBi EOG741Z2Q.
    TreeFami TF315953.

    Enzyme and pathway databases

    Reactomei REACT_197453. Small interfering RNA (siRNA) biogenesis.

    Miscellaneous databases

    NextBioi 35583958.
    PROi G3V7J2.

    Family and domain databases

    Gene3Di 3.30.160.20. 3 hits.
    InterProi IPR014720. dsRNA-bd_dom.
    [Graphical view ]
    Pfami PF00035. dsrm. 2 hits.
    [Graphical view ]
    SMARTi SM00358. DSRM. 3 hits.
    [Graphical view ]
    PROSITEi PS50137. DS_RBD. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. "Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS."
      Moser K., White F.M.
      J. Proteome Res. 5:98-104(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V7J2_RAT
    AccessioniPrimary (citable) accession number: G3V7J2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3