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G3V7D8

- G3V7D8_RAT

UniProt

G3V7D8 - G3V7D8_RAT

Protein

Toll-like receptor

Gene

Tlr4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. lipopolysaccharide receptor activity Source: Ensembl
    2. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. B cell proliferation involved in immune response Source: Ensembl
    3. cellular response to lipoteichoic acid Source: Ensembl
    4. cellular response to mechanical stimulus Source: Ensembl
    5. defense response to Gram-negative bacterium Source: Ensembl
    6. detection of lipopolysaccharide Source: Ensembl
    7. I-kappaB phosphorylation Source: Ensembl
    8. innate immune response Source: UniProtKB-KW
    9. interferon-gamma production Source: Ensembl
    10. intestinal epithelial structure maintenance Source: Ensembl
    11. macrophage activation Source: Ensembl
    12. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
    13. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
    14. negative regulation of interferon-gamma production Source: Ensembl
    15. negative regulation of interleukin-17 production Source: Ensembl
    16. negative regulation of interleukin-23 production Source: Ensembl
    17. negative regulation of interleukin-6 production Source: Ensembl
    18. negative regulation of tumor necrosis factor production Source: Ensembl
    19. nitric oxide production involved in inflammatory response Source: Ensembl
    20. positive regulation of B cell proliferation Source: Ensembl
    21. positive regulation of chemokine production Source: Ensembl
    22. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    23. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    24. positive regulation of interferon-alpha production Source: Ensembl
    25. positive regulation of interferon-beta biosynthetic process Source: Ensembl
    26. positive regulation of interferon-beta production Source: Ensembl
    27. positive regulation of interferon-gamma production Source: Ensembl
    28. positive regulation of interleukin-10 production Source: Ensembl
    29. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
    30. positive regulation of interleukin-12 production Source: Ensembl
    31. positive regulation of interleukin-1 production Source: Ensembl
    32. positive regulation of interleukin-6 production Source: Ensembl
    33. positive regulation of interleukin-8 biosynthetic process Source: Ensembl
    34. positive regulation of interleukin-8 production Source: Ensembl
    35. positive regulation of JNK cascade Source: Ensembl
    36. positive regulation of macrophage cytokine production Source: Ensembl
    37. positive regulation of MHC class II biosynthetic process Source: Ensembl
    38. positive regulation of NF-kappaB import into nucleus Source: Ensembl
    39. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    40. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    41. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    42. positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway Source: Ensembl
    43. positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Source: Ensembl
    44. positive regulation of platelet activation Source: Ensembl
    45. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    46. positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
    47. positive regulation of tumor necrosis factor production Source: Ensembl
    48. regulation of cytokine secretion Source: InterPro
    49. regulation of inflammatory response Source: Ensembl
    50. toll-like receptor 4 signaling pathway Source: InterPro

    Keywords - Molecular functioni

    ReceptorUniRule annotationImported

    Keywords - Biological processi

    Immunity, Inflammatory responseUniRule annotation, Innate immunityUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_194376. IKK complex recruitment mediated by RIP1.
    REACT_198288. TRIF-mediated programmed cell death.
    REACT_198983. TRAF6 mediated induction of TAK1 complex.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-like receptorUniRule annotation
    Gene namesi
    Name:Tlr4Imported
    ORF Names:rCG_55292Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi3870. Tlr4.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. integral component of plasma membrane Source: Ensembl
    3. lipopolysaccharide receptor complex Source: Ensembl
    4. perinuclear region of cytoplasm Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Toll-like receptor family.UniRule annotation
    Contains TIR domain.SAAS annotation

    Keywords - Domaini

    Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117512.
    OMAiNERNIEN.
    OrthoDBiEOG7ZKS9G.
    TreeFamiTF351113.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR000157. TIR_dom.
    IPR027168. TLR4.
    IPR017241. Toll-like_receptor.
    [Graphical view]
    PANTHERiPTHR24365:SF230. PTHR24365:SF230. 1 hit.
    PfamiPF13855. LRR_8. 3 hits.
    PF01582. TIR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
    SMARTiSM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS51450. LRR. 13 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3V7D8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMPLLHLAGT LIMALFLSCL RPGSLNPCIE VLPNITYQCM DQNLSKIPHD    50
    IPYSTKNLDL SFNPLKILRS YSFSNFSQLQ WLDLSRCEIE TIEDKAWHGL 100
    NQLSTLVLTG NPIKSFSPGS FSGLTNLENL VAVETKMTSL EGFHIGQLIS 150
    LKKLNVAHNL IHSFKLPEYF SNLTNLEHVD LSYNYIQTIS VKDLQFLREN 200
    PQVNLSLDLS LNPIDSIQAQ AFQGIRLHEL TLRSNFNSSN VLKMCLQNMT 250
    GLHVHRLILG EFKNERNLES FDRSVMEGLC NVSIDEFRLT YINHFSDDIY 300
    NLNCLANISA MSFTGVHIKH IADVPRHFKW QSLSIIRCHL KPFPKLSLPF 350
    LKSWTLTTNR EDISFGQLAL PSLRYLDLSR NAMSFRGCCS YSDFGTNNLK 400
    YLDLSFNGVI LMSANFMGLE ELEYLDFQHS TLKKVTEFSV FLSLEKLLYL 450
    DISYTNTKID FDGIFLGLIS LNTLKMAGNS FKDNTLSNVF TNTTNLTFLD 500
    LSKCQLEQIS RGVFDTLYRL QLLNMSHNNL LFLDPSHYKQ LYSLRTLDCS 550
    FNRIETSKGI LQHFPKSLAV FNLTNNSVAC ICEYQNFLQW VKDQKMFLVN 600
    VEQMKCASPI DMKASLVLDF TNSTCYIYKT IISVSVVSVL VVATVAFLIY 650
    HFYFHLILIA GCKKYSRGES IYDAFVIYSS QNEDWVRNEL VKNLEEGVPR 700
    FQLCLHYRDF IPGVAIAANI IQEGFHKSRK VIVVVSRHFI QSRWCIFEYE 750
    IAQTWQFLSS RSGIIFIVLE KVEKSLLRQQ VELYRLLSRN TYLEWEDNAL 800
    GRHIFWRRLK KALLDGKALN PDETSEEEQE ATTLT 835
    Length:835
    Mass (Da):96,058
    Last modified:November 16, 2011 - v1
    Checksum:iC45E4A4A735169B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06037636 Genomic DNA. No translation available.
    CH473978 Genomic DNA. Translation: EDM10505.1.
    UniGeneiRn.14534.

    Genome annotation databases

    EnsembliENSRNOT00000014020; ENSRNOP00000014020; ENSRNOG00000010522.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06037636 Genomic DNA. No translation available.
    CH473978 Genomic DNA. Translation: EDM10505.1 .
    UniGenei Rn.14534.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000014020 ; ENSRNOP00000014020 ; ENSRNOG00000010522 .

    Organism-specific databases

    RGDi 3870. Tlr4.

    Phylogenomic databases

    GeneTreei ENSGT00750000117512.
    OMAi NERNIEN.
    OrthoDBi EOG7ZKS9G.
    TreeFami TF351113.

    Enzyme and pathway databases

    Reactomei REACT_194376. IKK complex recruitment mediated by RIP1.
    REACT_198288. TRIF-mediated programmed cell death.
    REACT_198983. TRAF6 mediated induction of TAK1 complex.

    Miscellaneous databases

    NextBioi 35583921.
    PROi G3V7D8.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR000157. TIR_dom.
    IPR027168. TLR4.
    IPR017241. Toll-like_receptor.
    [Graphical view ]
    PANTHERi PTHR24365:SF230. PTHR24365:SF230. 1 hit.
    Pfami PF13855. LRR_8. 3 hits.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
    SMARTi SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS51450. LRR. 13 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V7D8_RAT
    AccessioniPrimary (citable) accession number: G3V7D8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3