G3V7D8 (G3V7D8_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Toll-like receptor PIRNR PIRNR037595

Gene names

Name:	Tlr4 EMBL EDM10505.1 Ensembl ENSRNOP00000014020 RGD 3870
ORF Names:	rCG_55292 EMBL EDM10505.1

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000014020

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	835 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the Toll-like receptor family. PIRNR PIRNR037595 Contains 1 TIR domain. SAAS SAAS000483

Ontologies

Keywords
Biological process	Immunity Inflammatory response PIRNR PIRNR037595 Innate immunity PIRNR PIRNR037595
Cellular component	Membrane
Domain	Leucine-rich repeat SAAS SAAS000157 Repeat SAAS SAAS000483 Transmembrane Transmembrane helix SAAS SAAS000483
Molecular function	Receptor PIRNR PIRNR037595 EMBL EDM10505.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	I-kappaB phosphorylation Inferred from electronic annotation. Source: Compara MyD88-dependent toll-like receptor signaling pathway Inferred from electronic annotation. Source: InterPro activation of MAPK activity Inferred from electronic annotation. Source: Compara cellular response to lipoteichoic acid Inferred from electronic annotation. Source: Compara cellular response to mechanical stimulus Inferred from electronic annotation. Source: Compara defense response to Gram-negative bacterium Inferred from electronic annotation. Source: Compara detection of lipopolysaccharide Inferred from electronic annotation. Source: Compara innate immune response Inferred from electronic annotation. Source: UniProtKB-KW interferon-gamma production Inferred from electronic annotation. Source: Compara intestinal epithelial structure maintenance Inferred from electronic annotation. Source: Compara macrophage activation Inferred from electronic annotation. Source: Compara negative regulation of ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara negative regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara negative regulation of interleukin-17 production Inferred from electronic annotation. Source: Compara negative regulation of interleukin-23 production Inferred from electronic annotation. Source: Compara negative regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara negative regulation of tumor necrosis factor production Inferred from electronic annotation. Source: Compara nitric oxide production involved in inflammatory response Inferred from electronic annotation. Source: Compara positive regulation of B cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara positive regulation of JNK cascade Inferred from electronic annotation. Source: Compara positive regulation of MHC class II biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of chemokine production Inferred from electronic annotation. Source: Compara positive regulation of interferon-alpha production Inferred from electronic annotation. Source: Compara positive regulation of interferon-beta biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of interferon-beta production Inferred from electronic annotation. Source: Compara positive regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-1 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-10 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-12 biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of interleukin-12 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-8 biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of interleukin-8 production Inferred from electronic annotation. Source: Compara positive regulation of macrophage cytokine production Inferred from electronic annotation. Source: Compara positive regulation of nitric oxide biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of nitric-oxide synthase biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of platelet activation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of tumor necrosis factor biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of tumor necrosis factor production Inferred from electronic annotation. Source: Compara regulation of cytokine secretion Inferred from electronic annotation. Source: InterPro regulation of inflammatory response Inferred from electronic annotation. Source: Compara toll-like receptor 4 signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred from electronic annotation. Source: Compara lipopolysaccharide receptor complex Inferred from electronic annotation. Source: Compara perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara
Molecular_function	lipopolysaccharide receptor activity Inferred from electronic annotation. Source: Compara transmembrane signaling receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G3V7D8 [UniParc]. Last modified November 16, 2011. Version 1. Checksum: C45E4A4A735169B5	FASTA	835	96,058
	10 20 30 40 50 60 MMPLLHLAGT LIMALFLSCL RPGSLNPCIE VLPNITYQCM DQNLSKIPHD IPYSTKNLDL 70 80 90 100 110 120 SFNPLKILRS YSFSNFSQLQ WLDLSRCEIE TIEDKAWHGL NQLSTLVLTG NPIKSFSPGS 130 140 150 160 170 180 FSGLTNLENL VAVETKMTSL EGFHIGQLIS LKKLNVAHNL IHSFKLPEYF SNLTNLEHVD 190 200 210 220 230 240 LSYNYIQTIS VKDLQFLREN PQVNLSLDLS LNPIDSIQAQ AFQGIRLHEL TLRSNFNSSN 250 260 270 280 290 300 VLKMCLQNMT GLHVHRLILG EFKNERNLES FDRSVMEGLC NVSIDEFRLT YINHFSDDIY 310 320 330 340 350 360 NLNCLANISA MSFTGVHIKH IADVPRHFKW QSLSIIRCHL KPFPKLSLPF LKSWTLTTNR 370 380 390 400 410 420 EDISFGQLAL PSLRYLDLSR NAMSFRGCCS YSDFGTNNLK YLDLSFNGVI LMSANFMGLE 430 440 450 460 470 480 ELEYLDFQHS TLKKVTEFSV FLSLEKLLYL DISYTNTKID FDGIFLGLIS LNTLKMAGNS 490 500 510 520 530 540 FKDNTLSNVF TNTTNLTFLD LSKCQLEQIS RGVFDTLYRL QLLNMSHNNL LFLDPSHYKQ 550 560 570 580 590 600 LYSLRTLDCS FNRIETSKGI LQHFPKSLAV FNLTNNSVAC ICEYQNFLQW VKDQKMFLVN 610 620 630 640 650 660 VEQMKCASPI DMKASLVLDF TNSTCYIYKT IISVSVVSVL VVATVAFLIY HFYFHLILIA 670 680 690 700 710 720 GCKKYSRGES IYDAFVIYSS QNEDWVRNEL VKNLEEGVPR FQLCLHYRDF IPGVAIAANI 730 740 750 760 770 780 IQEGFHKSRK VIVVVSRHFI QSRWCIFEYE IAQTWQFLSS RSGIIFIVLE KVEKSLLRQQ 790 800 810 820 830 VELYRLLSRN TYLEWEDNAL GRHIFWRRLK KALLDGKALN PDETSEEEQE ATTLT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000014020.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM10505.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDM10505.1.
[4]	Ensembl Submitted (SEP-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000014020.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06037636 Genomic DNA. No translation available. CH473978 Genomic DNA. Translation: EDM10505.1.
UniGene	Rn.14534.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000014020; ENSRNOP00000014020; ENSRNOG00000010522.
Organism-specific databases
RGD	3870. Tlr4.
Phylogenomic databases
GeneTree	ENSGT00700000104185.
OMA	RNATCQI.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR000157. TIR_dom. IPR027168. TLR4. IPR017241. Toll-like_receptor. [Graphical view]
PANTHER	PTHR24365:SF9. PTHR24365:SF9. 1 hit.
Pfam	PF01582. TIR. 1 hit. [Graphical view]
PIRSF	PIRSF037595. Toll-like_receptor. 1 hit.
SMART	SM00082. LRRCT. 1 hit. SM00255. TIR. 1 hit. [Graphical view]
SUPFAM	SSF52200. TIR. 1 hit.
PROSITE	PS51450. LRR. 13 hits. PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35583921.

Entry information

Entry name

G3V7D8_RAT

Accession

Primary (citable) accession number: G3V7D8

Entry history

Integrated into UniProtKB/TrEMBL:	November 16, 2011
Last sequence update:	November 16, 2011
Last modified:	May 1, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)