Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Toll-like receptor

Gene

Tlr4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. lipopolysaccharide receptor activity Source: Ensembl
  2. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. B cell proliferation involved in immune response Source: Ensembl
  3. cellular response to lipoteichoic acid Source: Ensembl
  4. cellular response to mechanical stimulus Source: Ensembl
  5. defense response to Gram-negative bacterium Source: Ensembl
  6. detection of lipopolysaccharide Source: Ensembl
  7. I-kappaB phosphorylation Source: Ensembl
  8. innate immune response Source: UniProtKB-KW
  9. interferon-gamma production Source: Ensembl
  10. intestinal epithelial structure maintenance Source: Ensembl
  11. macrophage activation Source: Ensembl
  12. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  13. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
  14. negative regulation of interferon-gamma production Source: Ensembl
  15. negative regulation of interleukin-17 production Source: Ensembl
  16. negative regulation of interleukin-23 production Source: Ensembl
  17. negative regulation of interleukin-6 production Source: Ensembl
  18. negative regulation of tumor necrosis factor production Source: Ensembl
  19. nitric oxide production involved in inflammatory response Source: Ensembl
  20. positive regulation of B cell proliferation Source: Ensembl
  21. positive regulation of chemokine production Source: Ensembl
  22. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  23. positive regulation of interferon-alpha production Source: Ensembl
  24. positive regulation of interferon-beta biosynthetic process Source: Ensembl
  25. positive regulation of interferon-gamma production Source: Ensembl
  26. positive regulation of interleukin-10 production Source: Ensembl
  27. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
  28. positive regulation of interleukin-1 production Source: Ensembl
  29. positive regulation of interleukin-6 production Source: Ensembl
  30. positive regulation of interleukin-8 biosynthetic process Source: Ensembl
  31. positive regulation of JNK cascade Source: Ensembl
  32. positive regulation of macrophage cytokine production Source: Ensembl
  33. positive regulation of MHC class II biosynthetic process Source: Ensembl
  34. positive regulation of NF-kappaB import into nucleus Source: Ensembl
  35. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  36. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  37. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  38. positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway Source: Ensembl
  39. positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Source: Ensembl
  40. positive regulation of platelet activation Source: Ensembl
  41. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  42. positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
  43. regulation of cytokine secretion Source: InterPro
  44. regulation of inflammatory response Source: Ensembl
  45. toll-like receptor 4 signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationSAAS annotation

Keywords - Biological processi

Immunity, Inflammatory responseUniRule annotation, Innate immunityUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_194376. IKK complex recruitment mediated by RIP1.
REACT_198288. TRIF-mediated programmed cell death.
REACT_198983. TRAF6 mediated induction of TAK1 complex.
REACT_247122. Toll Like Receptor 4 (TLR4) Cascade.
REACT_252403. MyD88:Mal cascade initiated on plasma membrane.
REACT_255658. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptorUniRule annotation
Gene namesi
Name:Tlr4Imported
ORF Names:rCG_55292Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi3870. Tlr4.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. integral component of plasma membrane Source: Ensembl
  3. lipopolysaccharide receptor complex Source: Ensembl
  4. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the Toll-like receptor family.UniRule annotation
Contains TIR domain.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119006.
OMAiRCEIETI.
OrthoDBiEOG7ZKS9G.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027168. TLR4.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF230. PTHR24365:SF230. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V7D8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMPLLHLAGT LIMALFLSCL RPGSLNPCIE VLPNITYQCM DQNLSKIPHD
60 70 80 90 100
IPYSTKNLDL SFNPLKILRS YSFSNFSQLQ WLDLSRCEIE TIEDKAWHGL
110 120 130 140 150
NQLSTLVLTG NPIKSFSPGS FSGLTNLENL VAVETKMTSL EGFHIGQLIS
160 170 180 190 200
LKKLNVAHNL IHSFKLPEYF SNLTNLEHVD LSYNYIQTIS VKDLQFLREN
210 220 230 240 250
PQVNLSLDLS LNPIDSIQAQ AFQGIRLHEL TLRSNFNSSN VLKMCLQNMT
260 270 280 290 300
GLHVHRLILG EFKNERNLES FDRSVMEGLC NVSIDEFRLT YINHFSDDIY
310 320 330 340 350
NLNCLANISA MSFTGVHIKH IADVPRHFKW QSLSIIRCHL KPFPKLSLPF
360 370 380 390 400
LKSWTLTTNR EDISFGQLAL PSLRYLDLSR NAMSFRGCCS YSDFGTNNLK
410 420 430 440 450
YLDLSFNGVI LMSANFMGLE ELEYLDFQHS TLKKVTEFSV FLSLEKLLYL
460 470 480 490 500
DISYTNTKID FDGIFLGLIS LNTLKMAGNS FKDNTLSNVF TNTTNLTFLD
510 520 530 540 550
LSKCQLEQIS RGVFDTLYRL QLLNMSHNNL LFLDPSHYKQ LYSLRTLDCS
560 570 580 590 600
FNRIETSKGI LQHFPKSLAV FNLTNNSVAC ICEYQNFLQW VKDQKMFLVN
610 620 630 640 650
VEQMKCASPI DMKASLVLDF TNSTCYIYKT IISVSVVSVL VVATVAFLIY
660 670 680 690 700
HFYFHLILIA GCKKYSRGES IYDAFVIYSS QNEDWVRNEL VKNLEEGVPR
710 720 730 740 750
FQLCLHYRDF IPGVAIAANI IQEGFHKSRK VIVVVSRHFI QSRWCIFEYE
760 770 780 790 800
IAQTWQFLSS RSGIIFIVLE KVEKSLLRQQ VELYRLLSRN TYLEWEDNAL
810 820 830
GRHIFWRRLK KALLDGKALN PDETSEEEQE ATTLT
Length:835
Mass (Da):96,058
Last modified:November 16, 2011 - v1
Checksum:iC45E4A4A735169B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06037636 Genomic DNA. No translation available.
CH473978 Genomic DNA. Translation: EDM10505.1.
UniGeneiRn.14534.

Genome annotation databases

EnsembliENSRNOT00000014020; ENSRNOP00000014020; ENSRNOG00000010522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06037636 Genomic DNA. No translation available.
CH473978 Genomic DNA. Translation: EDM10505.1.
UniGeneiRn.14534.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014020; ENSRNOP00000014020; ENSRNOG00000010522.

Organism-specific databases

RGDi3870. Tlr4.

Phylogenomic databases

GeneTreeiENSGT00760000119006.
OMAiRCEIETI.
OrthoDBiEOG7ZKS9G.
TreeFamiTF351113.

Enzyme and pathway databases

ReactomeiREACT_194376. IKK complex recruitment mediated by RIP1.
REACT_198288. TRIF-mediated programmed cell death.
REACT_198983. TRAF6 mediated induction of TAK1 complex.
REACT_247122. Toll Like Receptor 4 (TLR4) Cascade.
REACT_252403. MyD88:Mal cascade initiated on plasma membrane.
REACT_255658. Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.

Miscellaneous databases

NextBioi35583921.
PROiG3V7D8.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027168. TLR4.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF230. PTHR24365:SF230. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 13 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiG3V7D8_RAT
AccessioniPrimary (citable) accession number: G3V7D8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: February 4, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.