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Protein
Submitted name:

CD28 antigen

Gene

Cd28

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1257604 PIP3 activates AKT signaling
R-RNO-389356 CD28 co-stimulation
R-RNO-389357 CD28 dependent PI3K/Akt signaling
R-RNO-389359 CD28 dependent Vav1 pathway
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Submitted name:
CD28 antigenImported
Submitted name:
T-cell-specific surface glycoprotein CD28Imported
Gene namesi
Name:Cd28Imported
ORF Names:rCG_22337Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi2299 Cd28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei150 – 176HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501409175621 – 218Sequence analysisAdd BLAST198

Expressioni

Gene expression databases

BgeeiENSRNOG00000010283

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 139IGvInterPro annotationAdd BLAST112

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IXMM Eukaryota
ENOG410Z063 LUCA
GeneTreeiENSGT00530000063873
OMAiVNGNYSH
OrthoDBiEOG091G0IGY
TreeFamiTF335679

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR008093 CD28
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF15910 V-set_2, 1 hit
PRINTSiPR01717 CD28ANTIGEN
SUPFAMiSSF48726 SSF48726, 1 hit

Sequencei

Sequence statusi: Complete.

G3V7C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRLLFLAL SFFSVQVTEN KILVKQSPLL VVDNNEVSLS CRYSYNLLAK
60 70 80 90 100
EFRASLYKGV NSDVEVCVGN GNFTYQPQFR PNVGFNCDGN FDNETVTFRL
110 120 130 140 150
WNLHVNHTDI YFCKIEVMYP PPYLDNEKSN GTIIHIKEKH LCHAQTSPKL
160 170 180 190 200
FWALVVVAGV LLCYGLLVTV TLCIIWTNSR RNRLLQSDYM NMTPRRLGPT
210
RKHYQPYAPA RDFAAYRP
Length:218
Mass (Da):25,166
Last modified:November 16, 2011 - v1
Checksum:i720FB31BB38B0DB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07073487 Genomic DNA No translation available.
AC112446 Genomic DNA No translation available.
CH473965 Genomic DNA Translation: EDL98926.1
UniGeneiRn.10327

Genome annotation databases

EnsembliENSRNOT00000013701; ENSRNOP00000013701; ENSRNOG00000010283

Similar proteinsi

Entry informationi

Entry nameiG3V7C2_RAT
AccessioniPrimary (citable) accession number: G3V7C2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health