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Protein
Submitted name:

CD28 antigen

Gene

Cd28

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-389356. CD28 co-stimulation.
R-RNO-389357. CD28 dependent PI3K/Akt signaling.
R-RNO-389359. CD28 dependent Vav1 pathway.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
CD28 antigenImported
Submitted name:
T-cell-specific surface glycoprotein CD28Imported
Gene namesi
Name:Cd28Imported
ORF Names:rCG_22337Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi2299. Cd28.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei150 – 176HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501083378021 – 218Sequence analysisAdd BLAST198

Expressioni

Gene expression databases

BgeeiENSRNOG00000010283.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 139IGvInterPro annotationAdd BLAST112

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IXMM. Eukaryota.
ENOG410Z063. LUCA.
GeneTreeiENSGT00530000063873.
OMAiVNGNYSH.
OrthoDBiEOG091G0IGY.
TreeFamiTF335679.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR008093. CD28.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF15910. V-set_2. 1 hit.
PRINTSiPR01717. CD28ANTIGEN.
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

G3V7C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRLLFLAL SFFSVQVTEN KILVKQSPLL VVDNNEVSLS CRYSYNLLAK
60 70 80 90 100
EFRASLYKGV NSDVEVCVGN GNFTYQPQFR PNVGFNCDGN FDNETVTFRL
110 120 130 140 150
WNLHVNHTDI YFCKIEVMYP PPYLDNEKSN GTIIHIKEKH LCHAQTSPKL
160 170 180 190 200
FWALVVVAGV LLCYGLLVTV TLCIIWTNSR RNRLLQSDYM NMTPRRLGPT
210
RKHYQPYAPA RDFAAYRP
Length:218
Mass (Da):25,166
Last modified:November 16, 2011 - v1
Checksum:i720FB31BB38B0DB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07073487 Genomic DNA. No translation available.
AC112446 Genomic DNA. No translation available.
CH473965 Genomic DNA. Translation: EDL98926.1.
UniGeneiRn.10327.

Genome annotation databases

EnsembliENSRNOT00000013701; ENSRNOP00000013701; ENSRNOG00000010283.

Similar proteinsi

Entry informationi

Entry nameiG3V7C2_RAT
AccessioniPrimary (citable) accession number: G3V7C2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: August 30, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported