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Protein
Submitted name:

Low density lipoprotein receptor, isoform CRA_a

Gene

Ldlr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Enzyme and pathway databases

ReactomeiR-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.
R-RNO-8964026. Chylomicron clearance.
R-RNO-8964038. LDL clearance.

Names & Taxonomyi

Protein namesi
Submitted name:
Low density lipoprotein receptor, isoform CRA_aImported
Submitted name:
Low-density lipoprotein receptorImported
Gene namesi
Name:LdlrImported
ORF Names:rCG_31837Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi2998. Ldlr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei806 – 829HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501049714324 – 879Sequence analysisAdd BLAST856

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 39PROSITE-ProRule annotation
Disulfide bondi34 ↔ 52PROSITE-ProRule annotation
Disulfide bondi89 ↔ 104PROSITE-ProRule annotation
Disulfide bondi109 ↔ 121PROSITE-ProRule annotation
Disulfide bondi116 ↔ 134PROSITE-ProRule annotation
Disulfide bondi128 ↔ 143PROSITE-ProRule annotation
Disulfide bondi148 ↔ 160PROSITE-ProRule annotation
Disulfide bondi155 ↔ 173PROSITE-ProRule annotation
Disulfide bondi198 ↔ 210PROSITE-ProRule annotation
Disulfide bondi205 ↔ 223PROSITE-ProRule annotation
Disulfide bondi217 ↔ 232PROSITE-ProRule annotation
Disulfide bondi237 ↔ 249PROSITE-ProRule annotation
Disulfide bondi244 ↔ 262PROSITE-ProRule annotation
Disulfide bondi256 ↔ 271PROSITE-ProRule annotation
Disulfide bondi285 ↔ 303PROSITE-ProRule annotation
Disulfide bondi359 ↔ 369PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation, LipoproteinImported

Expressioni

Gene expression databases

BgeeiENSRNOG00000009946.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini315 – 354EGF-likeInterPro annotationAdd BLAST40
Domaini355 – 394EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410KD0U. Eukaryota.
ENOG410Z5FJ. LUCA.
GeneTreeiENSGT00760000118968.
OMAiINVTLCE.
OrthoDBiEOG091G01MX.
TreeFamiTF351700.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiView protein in InterPro
IPR011042. 6-blade_b-propeller_TolB-like.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
PfamiView protein in Pfam
PF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 7 hits.
PF00058. Ldl_recept_b. 5 hits.
PRINTSiPR00261. LDLRECEPTOR.
SMARTiView protein in SMART
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00192. LDLa. 7 hits.
SM00135. LY. 5 hits.
SUPFAMiSSF57184. SSF57184. 2 hits.
SSF57424. SSF57424. 7 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 2 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 4 hits.
PS50068. LDLRA_2. 7 hits.
PS51120. LDLRB. 5 hits.

Sequencei

Sequence statusi: Complete.

G3V7A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTADLMLRW AIALLLAAAG VAAEDSCGKN EFQCRDGKCI VSKWVCDGSR
60 70 80 90 100
ECPDGSDESP ETCMSVTCRS GEFSCGGRVS RCIPDSWRCD GRTDCENGSD
110 120 130 140 150
ELDCSPKTCS LDEFRCQDGK CISRQFVCDQ DWDCLDGSDE AHCAATTCGP
160 170 180 190 200
AHFRCNSSSC IPSLWACDGD RDCDDGSDEW PQNCGGRDTA AEVVSSPCSS
210 220 230 240 250
LEFHCGSSEC IHRSWVCDGA ADCKDKSDEE NCAVTTCRPD EFQCADGSCI
260 270 280 290 300
HGSRQCDREH DCKDMSDELG CINVTQCDGP NKFKCHSGEC ISLDKVCNSA
310 320 330 340 350
RDCRDWSDEP IKECKTNECL DNNGGCSHIC KDLKIGYECL CPSGFRLVDG
360 370 380 390 400
HQCEDIDECQ EPDTCSQLCV NLEGSFKCEC RAGFHMDPHT RVCKAVGSIG
410 420 430 440 450
FLLFTNRHEV RKMTLDRSEY TSLIPNLKNV VALDTEVANN RIYWSDLSQR
460 470 480 490 500
KIYSAVMDQG TSLSYDAIIS GDLHAPDGLA VDWIHGNIYW TDSVPGTVSV
510 520 530 540 550
ADTKGVRRRT LFREKGSRPR AIVVDPVHGF MYWTDWGTPA KIKKGGLNGV
560 570 580 590 600
DIYSLVTEDI QWPNGITLDL PSGRLYWVDS KLHSISSIDV NGGGRKTILE
610 620 630 640 650
DEKQLAHPFS LAIYEDKVYW TDVLNEAIFS ANRLTGSDVN LVAKNLMSPE
660 670 680 690 700
DIVLFHNVTQ PRGVNWCEAT VLPNGGCQYM CLPAPQISAH SPKFTCACPD
710 720 730 740 750
GMLLAKDMRS CLPEVDTVPT TQGTSTIGPV VTTSAAVSLK RKEDPSATRH
760 770 780 790 800
KEDPSATRHK EDPSATSTSR QPGDTPELST VESVTVSSQV QGDMAGRGDE
810 820 830 840 850
VQRHGVGFLS IFLPIALVAL LVFGAILLWR NWRLRNINSI NFDNPVYQKT
860 870
TEDEIHICRS QDGYTYPSRQ MVSLEDDVA
Length:879
Mass (Da):96,649
Last modified:November 16, 2011 - v1
Checksum:iF7026AAB0C9FF4BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC119556 Genomic DNA. No translation available.
CH473993 Genomic DNA. Translation: EDL78274.1.

Genome annotation databases

EnsembliENSRNOT00000013496; ENSRNOP00000013496; ENSRNOG00000009946.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiG3V7A5_RAT
AccessioniPrimary (citable) accession number: G3V7A5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: July 5, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported