Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

G3V7A5

- G3V7A5_RAT

UniProt

G3V7A5 - G3V7A5_RAT

Protein
Submitted name:

Low density lipoprotein receptor, isoform CRA_a

Gene

Ldlr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. low-density lipoprotein particle binding Source: Ensembl
    3. low-density lipoprotein receptor activity Source: Ensembl
    4. very-low-density lipoprotein particle receptor activity Source: Ensembl

    GO - Biological processi

    1. cholesterol homeostasis Source: Ensembl
    2. cholesterol import Source: Ensembl
    3. cholesterol metabolic process Source: Ensembl
    4. intestinal cholesterol absorption Source: Ensembl
    5. lipoprotein catabolic process Source: Ensembl
    6. low-density lipoprotein particle clearance Source: Ensembl
    7. phospholipid transport Source: Ensembl
    8. positive regulation of triglyceride biosynthetic process Source: Ensembl
    9. regulation of phosphatidylcholine catabolic process Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Enzyme and pathway databases

    ReactomeiREACT_199015. Retinoid metabolism and transport.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Low density lipoprotein receptor, isoform CRA_aImported
    Submitted name:
    Low-density lipoprotein receptorImported
    Gene namesi
    Name:LdlrImported
    ORF Names:rCG_31837Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi2998. Ldlr.

    Subcellular locationi

    GO - Cellular componenti

    1. coated pit Source: Ensembl
    2. early endosome Source: Ensembl
    3. external side of plasma membrane Source: Ensembl
    4. Golgi apparatus Source: Ensembl
    5. integral component of membrane Source: UniProtKB-KW
    6. late endosome Source: Ensembl
    7. lysosome Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation, LipoproteinImported

    Family & Domainsi

    Keywords - Domaini

    EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114992.
    OMAiGQVDCEN.
    OrthoDBiEOG7NGQ9P.
    TreeFamiTF351700.

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    4.10.400.10. 7 hits.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR023415. LDLR_class-A_CS.
    IPR000033. LDLR_classB_rpt.
    IPR002172. LDrepeatLR_classA_rpt.
    [Graphical view]
    PfamiPF07645. EGF_CA. 1 hit.
    PF00057. Ldl_recept_a. 7 hits.
    PF00058. Ldl_recept_b. 5 hits.
    [Graphical view]
    PRINTSiPR00261. LDLRECEPTOR.
    SMARTiSM00181. EGF. 2 hits.
    SM00179. EGF_CA. 1 hit.
    SM00192. LDLa. 7 hits.
    SM00135. LY. 5 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 2 hits.
    SSF57424. SSF57424. 7 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 2 hits.
    PS01187. EGF_CA. 1 hit.
    PS01209. LDLRA_1. 7 hits.
    PS50068. LDLRA_2. 7 hits.
    PS51120. LDLRB. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3V7A5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTADLMLRW AIALLLAAAG VAAEDSCGKN EFQCRDGKCI VSKWVCDGSR    50
    ECPDGSDESP ETCMSVTCRS GEFSCGGRVS RCIPDSWRCD GRTDCENGSD 100
    ELDCSPKTCS LDEFRCQDGK CISRQFVCDQ DWDCLDGSDE AHCAATTCGP 150
    AHFRCNSSSC IPSLWACDGD RDCDDGSDEW PQNCGGRDTA AEVVSSPCSS 200
    LEFHCGSSEC IHRSWVCDGA ADCKDKSDEE NCAVTTCRPD EFQCADGSCI 250
    HGSRQCDREH DCKDMSDELG CINVTQCDGP NKFKCHSGEC ISLDKVCNSA 300
    RDCRDWSDEP IKECKTNECL DNNGGCSHIC KDLKIGYECL CPSGFRLVDG 350
    HQCEDIDECQ EPDTCSQLCV NLEGSFKCEC RAGFHMDPHT RVCKAVGSIG 400
    FLLFTNRHEV RKMTLDRSEY TSLIPNLKNV VALDTEVANN RIYWSDLSQR 450
    KIYSAVMDQG TSLSYDAIIS GDLHAPDGLA VDWIHGNIYW TDSVPGTVSV 500
    ADTKGVRRRT LFREKGSRPR AIVVDPVHGF MYWTDWGTPA KIKKGGLNGV 550
    DIYSLVTEDI QWPNGITLDL PSGRLYWVDS KLHSISSIDV NGGGRKTILE 600
    DEKQLAHPFS LAIYEDKVYW TDVLNEAIFS ANRLTGSDVN LVAKNLMSPE 650
    DIVLFHNVTQ PRGVNWCEAT VLPNGGCQYM CLPAPQISAH SPKFTCACPD 700
    GMLLAKDMRS CLPEVDTVPT TQGTSTIGPV VTTSAAVSLK RKEDPSATRH 750
    KEDPSATRHK EDPSATSTSR QPGDTPELST VESVTVSSQV QGDMAGRGDE 800
    VQRHGVGFLS IFLPIALVAL LVFGAILLWR NWRLRNINSI NFDNPVYQKT 850
    TEDEIHICRS QDGYTYPSRQ MVSLEDDVA 879
    Length:879
    Mass (Da):96,649
    Last modified:November 16, 2011 - v1
    Checksum:iF7026AAB0C9FF4BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06053687 Genomic DNA. No translation available.
    CH473993 Genomic DNA. Translation: EDL78274.1.

    Genome annotation databases

    EnsembliENSRNOT00000013496; ENSRNOP00000013496; ENSRNOG00000009946.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06053687 Genomic DNA. No translation available.
    CH473993 Genomic DNA. Translation: EDL78274.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000013496 ; ENSRNOP00000013496 ; ENSRNOG00000009946 .

    Organism-specific databases

    RGDi 2998. Ldlr.

    Phylogenomic databases

    GeneTreei ENSGT00740000114992.
    OMAi GQVDCEN.
    OrthoDBi EOG7NGQ9P.
    TreeFami TF351700.

    Enzyme and pathway databases

    Reactomei REACT_199015. Retinoid metabolism and transport.

    Miscellaneous databases

    NextBioi 35583897.
    PROi G3V7A5.

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    4.10.400.10. 7 hits.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR023415. LDLR_class-A_CS.
    IPR000033. LDLR_classB_rpt.
    IPR002172. LDrepeatLR_classA_rpt.
    [Graphical view ]
    Pfami PF07645. EGF_CA. 1 hit.
    PF00057. Ldl_recept_a. 7 hits.
    PF00058. Ldl_recept_b. 5 hits.
    [Graphical view ]
    PRINTSi PR00261. LDLRECEPTOR.
    SMARTi SM00181. EGF. 2 hits.
    SM00179. EGF_CA. 1 hit.
    SM00192. LDLa. 7 hits.
    SM00135. LY. 5 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 2 hits.
    SSF57424. SSF57424. 7 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
    PS01186. EGF_2. 2 hits.
    PS50026. EGF_3. 2 hits.
    PS01187. EGF_CA. 1 hit.
    PS01209. LDLRA_1. 7 hits.
    PS50068. LDLRA_2. 7 hits.
    PS51120. LDLRB. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V7A5_RAT
    AccessioniPrimary (citable) accession number: G3V7A5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3