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G3V7A5 (G3V7A5_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Low-density lipoprotein receptor Ensembl ENSRNOP00000013496
Gene names
Name:Ldlr EMBL EDL78274.1 RGD 2998 Ensembl ENSRNOP00000013496
ORF Names:rCG_31837 EMBL EDL78274.1
OrganismRattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000013496
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length879 AA.
Sequence statusComplete.
Protein existencePredicted

Ontologies

Keywords
   Cellular componentMembrane
   DomainEGF-like domain SAAS SAAS011042 RuleBase RU000459
Repeat SAAS SAAS011042
Transmembrane
Transmembrane helix SAAS SAAS000033
   Molecular functionReceptor EMBL EDL78274.1
   PTMDisulfide bond SAAS SAAS011042
Lipoprotein EMBL EDL78274.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcholesterol homeostasis

Inferred from electronic annotation. Source: Ensembl

cholesterol import

Inferred from electronic annotation. Source: Ensembl

cholesterol metabolic process

Inferred from electronic annotation. Source: Ensembl

intestinal cholesterol absorption

Inferred from electronic annotation. Source: Ensembl

lipoprotein catabolic process

Inferred from electronic annotation. Source: Ensembl

low-density lipoprotein particle clearance

Inferred from electronic annotation. Source: Ensembl

phospholipid transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of triglyceride biosynthetic process

Inferred from electronic annotation. Source: Ensembl

regulation of phosphatidylcholine catabolic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

coated pit

Inferred from electronic annotation. Source: Ensembl

early endosome

Inferred from electronic annotation. Source: Ensembl

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

late endosome

Inferred from electronic annotation. Source: Ensembl

lysosome

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

low-density lipoprotein particle binding

Inferred from electronic annotation. Source: Ensembl

low-density lipoprotein receptor activity

Inferred from electronic annotation. Source: Ensembl

very-low-density lipoprotein particle receptor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
G3V7A5 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: F7026AAB0C9FF4BD

FASTA87996,649
        10         20         30         40         50         60 
MSTADLMLRW AIALLLAAAG VAAEDSCGKN EFQCRDGKCI VSKWVCDGSR ECPDGSDESP 

        70         80         90        100        110        120 
ETCMSVTCRS GEFSCGGRVS RCIPDSWRCD GRTDCENGSD ELDCSPKTCS LDEFRCQDGK 

       130        140        150        160        170        180 
CISRQFVCDQ DWDCLDGSDE AHCAATTCGP AHFRCNSSSC IPSLWACDGD RDCDDGSDEW 

       190        200        210        220        230        240 
PQNCGGRDTA AEVVSSPCSS LEFHCGSSEC IHRSWVCDGA ADCKDKSDEE NCAVTTCRPD 

       250        260        270        280        290        300 
EFQCADGSCI HGSRQCDREH DCKDMSDELG CINVTQCDGP NKFKCHSGEC ISLDKVCNSA 

       310        320        330        340        350        360 
RDCRDWSDEP IKECKTNECL DNNGGCSHIC KDLKIGYECL CPSGFRLVDG HQCEDIDECQ 

       370        380        390        400        410        420 
EPDTCSQLCV NLEGSFKCEC RAGFHMDPHT RVCKAVGSIG FLLFTNRHEV RKMTLDRSEY 

       430        440        450        460        470        480 
TSLIPNLKNV VALDTEVANN RIYWSDLSQR KIYSAVMDQG TSLSYDAIIS GDLHAPDGLA 

       490        500        510        520        530        540 
VDWIHGNIYW TDSVPGTVSV ADTKGVRRRT LFREKGSRPR AIVVDPVHGF MYWTDWGTPA 

       550        560        570        580        590        600 
KIKKGGLNGV DIYSLVTEDI QWPNGITLDL PSGRLYWVDS KLHSISSIDV NGGGRKTILE 

       610        620        630        640        650        660 
DEKQLAHPFS LAIYEDKVYW TDVLNEAIFS ANRLTGSDVN LVAKNLMSPE DIVLFHNVTQ 

       670        680        690        700        710        720 
PRGVNWCEAT VLPNGGCQYM CLPAPQISAH SPKFTCACPD GMLLAKDMRS CLPEVDTVPT 

       730        740        750        760        770        780 
TQGTSTIGPV VTTSAAVSLK RKEDPSATRH KEDPSATRHK EDPSATSTSR QPGDTPELST 

       790        800        810        820        830        840 
VESVTVSSQV QGDMAGRGDE VQRHGVGFLS IFLPIALVAL LVFGAILLWR NWRLRNINSI 

       850        860        870 
NFDNPVYQKT TEDEIHICRS QDGYTYPSRQ MVSLEDDVA 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
Rat Genome Sequencing Project Consortium
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. expand/collapse author list , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Brown Norway Ensembl ENSRNOP00000013496.
[2]"Gene and alternative splicing annotation with AIR."
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G.
Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL78274.1.
[3]Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. expand/collapse author list , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BN EMBL EDL78274.1.
[4]Ensembl
Submitted (SEP-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Brown Norway Ensembl ENSRNOP00000013496.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AABR06053687 Genomic DNA. No translation available.
CH473993 Genomic DNA. Translation: EDL78274.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000013496; ENSRNOP00000013496; ENSRNOG00000009946.

Organism-specific databases

RGD2998. Ldlr.

Phylogenomic databases

GeneTreeENSGT00740000114992.
OMAGQVDCEN.
OrthoDBEOG7NGQ9P.
TreeFamTF351700.

Family and domain databases

Gene3D2.120.10.30. 1 hit.
4.10.400.10. 7 hits.
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamPF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 7 hits.
PF00058. Ldl_recept_b. 5 hits.
[Graphical view]
PRINTSPR00261. LDLRECEPTOR.
SMARTSM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00192. LDLa. 7 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMSSF57184. SSF57184. 2 hits.
SSF57424. SSF57424. 7 hits.
PROSITEPS00010. ASX_HYDROXYL. 2 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 7 hits.
PS50068. LDLRA_2. 7 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio35583897.
PROG3V7A5.

Entry information

Entry nameG3V7A5_RAT
AccessionPrimary (citable) accession number: G3V7A5
Entry history
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 16, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)