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G3V7A5

- G3V7A5_RAT

UniProt

G3V7A5 - G3V7A5_RAT

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Protein
Submitted name:

Low density lipoprotein receptor, isoform CRA_a

Gene
Ldlr, rCG_31837
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. low-density lipoprotein particle binding Source: Ensembl
  3. low-density lipoprotein receptor activity Source: Ensembl
  4. very-low-density lipoprotein particle receptor activity Source: Ensembl

GO - Biological processi

  1. cholesterol homeostasis Source: Ensembl
  2. cholesterol import Source: Ensembl
  3. cholesterol metabolic process Source: Ensembl
  4. intestinal cholesterol absorption Source: Ensembl
  5. lipoprotein catabolic process Source: Ensembl
  6. low-density lipoprotein particle clearance Source: Ensembl
  7. phospholipid transport Source: Ensembl
  8. positive regulation of triglyceride biosynthetic process Source: Ensembl
  9. regulation of phosphatidylcholine catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiREACT_199015. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Submitted name:
Low density lipoprotein receptor, isoform CRA_aImported
Submitted name:
Low-density lipoprotein receptorImported
Gene namesi
Name:LdlrImported
ORF Names:rCG_31837Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi2998. Ldlr.

Subcellular locationi

GO - Cellular componenti

  1. coated pit Source: Ensembl
  2. early endosome Source: Ensembl
  3. external side of plasma membrane Source: Ensembl
  4. Golgi apparatus Source: Ensembl
  5. integral component of membrane Source: UniProtKB-KW
  6. late endosome Source: Ensembl
  7. lysosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations, LipoproteinImported

Family & Domainsi

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotations, RepeatSAAS annotations, Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000114992.
OMAiGQVDCEN.
OrthoDBiEOG7NGQ9P.
TreeFamiTF351700.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
4.10.400.10. 7 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 7 hits.
PF00058. Ldl_recept_b. 5 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00192. LDLa. 7 hits.
SM00135. LY. 5 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
SSF57424. SSF57424. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 7 hits.
PS50068. LDLRA_2. 7 hits.
PS51120. LDLRB. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V7A5-1 [UniParc]FASTAAdd to Basket

« Hide

MSTADLMLRW AIALLLAAAG VAAEDSCGKN EFQCRDGKCI VSKWVCDGSR    50
ECPDGSDESP ETCMSVTCRS GEFSCGGRVS RCIPDSWRCD GRTDCENGSD 100
ELDCSPKTCS LDEFRCQDGK CISRQFVCDQ DWDCLDGSDE AHCAATTCGP 150
AHFRCNSSSC IPSLWACDGD RDCDDGSDEW PQNCGGRDTA AEVVSSPCSS 200
LEFHCGSSEC IHRSWVCDGA ADCKDKSDEE NCAVTTCRPD EFQCADGSCI 250
HGSRQCDREH DCKDMSDELG CINVTQCDGP NKFKCHSGEC ISLDKVCNSA 300
RDCRDWSDEP IKECKTNECL DNNGGCSHIC KDLKIGYECL CPSGFRLVDG 350
HQCEDIDECQ EPDTCSQLCV NLEGSFKCEC RAGFHMDPHT RVCKAVGSIG 400
FLLFTNRHEV RKMTLDRSEY TSLIPNLKNV VALDTEVANN RIYWSDLSQR 450
KIYSAVMDQG TSLSYDAIIS GDLHAPDGLA VDWIHGNIYW TDSVPGTVSV 500
ADTKGVRRRT LFREKGSRPR AIVVDPVHGF MYWTDWGTPA KIKKGGLNGV 550
DIYSLVTEDI QWPNGITLDL PSGRLYWVDS KLHSISSIDV NGGGRKTILE 600
DEKQLAHPFS LAIYEDKVYW TDVLNEAIFS ANRLTGSDVN LVAKNLMSPE 650
DIVLFHNVTQ PRGVNWCEAT VLPNGGCQYM CLPAPQISAH SPKFTCACPD 700
GMLLAKDMRS CLPEVDTVPT TQGTSTIGPV VTTSAAVSLK RKEDPSATRH 750
KEDPSATRHK EDPSATSTSR QPGDTPELST VESVTVSSQV QGDMAGRGDE 800
VQRHGVGFLS IFLPIALVAL LVFGAILLWR NWRLRNINSI NFDNPVYQKT 850
TEDEIHICRS QDGYTYPSRQ MVSLEDDVA 879
Length:879
Mass (Da):96,649
Last modified:November 16, 2011 - v1
Checksum:iF7026AAB0C9FF4BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06053687 Genomic DNA. No translation available.
CH473993 Genomic DNA. Translation: EDL78274.1.

Genome annotation databases

EnsembliENSRNOT00000013496; ENSRNOP00000013496; ENSRNOG00000009946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06053687 Genomic DNA. No translation available.
CH473993 Genomic DNA. Translation: EDL78274.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000013496 ; ENSRNOP00000013496 ; ENSRNOG00000009946 .

Organism-specific databases

RGDi 2998. Ldlr.

Phylogenomic databases

GeneTreei ENSGT00740000114992.
OMAi GQVDCEN.
OrthoDBi EOG7NGQ9P.
TreeFami TF351700.

Enzyme and pathway databases

Reactomei REACT_199015. Retinoid metabolism and transport.

Miscellaneous databases

NextBioi 35583897.
PROi G3V7A5.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
4.10.400.10. 7 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view ]
Pfami PF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 7 hits.
PF00058. Ldl_recept_b. 5 hits.
[Graphical view ]
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00192. LDLa. 7 hits.
SM00135. LY. 5 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 2 hits.
SSF57424. SSF57424. 7 hits.
PROSITEi PS00010. ASX_HYDROXYL. 2 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 7 hits.
PS50068. LDLRA_2. 7 hits.
PS51120. LDLRB. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiG3V7A5_RAT
AccessioniPrimary (citable) accession number: G3V7A5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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