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Protein

Solute carrier organic anion transporter family member

Gene

Slco1c1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transportUniRule annotation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-879518. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family memberUniRule annotation
Gene namesi
Name:Slco1c1Imported
ORF Names:rCG_30052Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi628660. Slco1c1.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei80 – 9920HelicalUniRule annotationAdd
BLAST
Transmembranei111 – 13323HelicalUniRule annotationAdd
BLAST
Transmembranei224 – 25431HelicalUniRule annotationAdd
BLAST
Transmembranei274 – 29825HelicalUniRule annotationAdd
BLAST
Transmembranei359 – 37719HelicalUniRule annotationAdd
BLAST
Transmembranei397 – 41822HelicalUniRule annotationAdd
BLAST
Transmembranei430 – 45021HelicalUniRule annotationAdd
BLAST
Transmembranei554 – 58128HelicalUniRule annotationAdd
BLAST
Transmembranei593 – 61624HelicalUniRule annotationAdd
BLAST
Transmembranei645 – 66824HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013230.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 672628MFSInterPro annotationAdd
BLAST
Domaini474 – 52956Kazal-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]UniRule annotation
Contains 1 Kazal-like domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
OMAiYWPGKET.
OrthoDBiEOG7GFB4C.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
IPR030764. OATP1C1.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PTHR11388:SF99. PTHR11388:SF99. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSSKENAH LFHKNSAQPA GGPSFKAGYP STEEARPCCG KLKVFLGALS
60 70 80 90 100
FVYFAKALAE GYLKSTITQI ERRFDIPSSL VGIIDGSFEI GNLLVITFVS
110 120 130 140 150
YFGAKLHRPK IIGAGCLVMG FGTMLIAVPQ FFMEKYSYEK YERYSPSSNL
160 170 180 190 200
TPNISPCYLE SSSPSPRSIV GKSQNKINDE CEVDTSSSMW VYVFLGNLLR
210 220 230 240 250
GLGETPIQPL GIAYLDDFAS EDNAAFYIGC VQTVAIIGPI FGFLLGSLCA
260 270 280 290 300
KLYVDIGFVN LDHITITPKD PQWVGAWWLG YLIAGFLSLL AAVPFWCLPK
310 320 330 340 350
TLPRSQSRED SGSSSEKSKF ITDDPVNYQM APREESMKIM EMARDFLPSL
360 370 380 390 400
KSLFRNPVYI LYLCASTVQF NSLFGMVTYK PKYIEQQYGQ SSSKANFVIG
410 420 430 440 450
LINIPAVALG IFSGGIVMKK FRLGICEATK LYLGSSVFGY LLFLSLFALG
460 470 480 490 500
CENSSVAGLT VSYQGTKPVS YHERALFSDC NSRCKCSDSK WEPMCGDNGI
510 520 530 540 550
TYASACLAGC QSSSRSGKNI IFSNCTCVGF AAPKSGNWSG MMGRCQKDNG
560 570 580 590 600
CSQMFLYFLV ISVITSYTLS LGGIPGYILL LRCIQPQLKS FALGIYTLAV
610 620 630 640 650
RVLAGIPAPV YFGVLIDTSC LKWGFKKCGS RGSCRLYDSH AFRHIYLGLT
660 670 680 690 700
TLLGTVSVFL STAVLLVLKK KYVSKRSSFI TAREKIVMSS SVKKETCAAR
710
DHGLQPKYWP GKETRL
Length:716
Mass (Da):78,597
Last modified:November 16, 2011 - v1
Checksum:iCAEBE972BEB0AD5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07062412 Genomic DNA. No translation available.
AABR07062413 Genomic DNA. No translation available.
AABR07073081 Genomic DNA. No translation available.
AC142420 Genomic DNA. No translation available.
CH473964 Genomic DNA. Translation: EDM01549.1.
RefSeqiXP_006237664.1. XM_006237602.1.
UniGeneiRn.45744.

Genome annotation databases

EnsembliENSRNOT00000013230; ENSRNOP00000013230; ENSRNOG00000009740.
GeneIDi84511.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07062412 Genomic DNA. No translation available.
AABR07062413 Genomic DNA. No translation available.
AABR07073081 Genomic DNA. No translation available.
AC142420 Genomic DNA. No translation available.
CH473964 Genomic DNA. Translation: EDM01549.1.
RefSeqiXP_006237664.1. XM_006237602.1.
UniGeneiRn.45744.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013230.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013230; ENSRNOP00000013230; ENSRNOG00000009740.
GeneIDi84511.

Organism-specific databases

CTDi53919.
RGDi628660. Slco1c1.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
OMAiYWPGKET.
OrthoDBiEOG7GFB4C.
TreeFamiTF317540.

Enzyme and pathway databases

ReactomeiR-RNO-879518. Transport of organic anions.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
IPR030764. OATP1C1.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PTHR11388:SF99. PTHR11388:SF99. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 5 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiG3V795_RAT
AccessioniPrimary (citable) accession number: G3V795
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 8, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.