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G3V780

- G3V780_RAT

UniProt

G3V780 - G3V780_RAT

Protein
Submitted name:

Interleukin 12a, isoform CRA_a

Gene

Il12a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cell cycle arrest Source: Ensembl
    2. cell migration Source: Ensembl
    3. defense response to Gram-positive bacterium Source: Ensembl
    4. defense response to protozoan Source: Ensembl
    5. extrinsic apoptotic signaling pathway Source: Ensembl
    6. immune response Source: InterPro
    7. negative regulation of interleukin-17 production Source: Ensembl
    8. negative regulation of smooth muscle cell proliferation Source: Ensembl
    9. positive regulation of cell adhesion Source: Ensembl
    10. positive regulation of interferon-gamma production Source: Ensembl
    11. positive regulation of natural killer cell activation Source: Ensembl
    12. positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: Ensembl
    13. positive regulation of NK T cell activation Source: Ensembl
    14. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
    15. positive regulation of T cell differentiation Source: Ensembl
    16. positive regulation of T cell mediated cytotoxicity Source: Ensembl
    17. positive regulation of T cell proliferation Source: Ensembl
    18. positive regulation of tyrosine phosphorylation of Stat4 protein Source: Ensembl
    19. response to lipopolysaccharide Source: Ensembl
    20. response to UV-B Source: Ensembl
    21. response to virus Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Interleukin 12a, isoform CRA_aImported
    Submitted name:
    Interleukin-12 subunit alphaImported
    Gene namesi
    Name:Il12aImported
    ORF Names:rCG_62487Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi620562. Il12a.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. interleukin-12 complex Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000016906.
    OMAiMNAKLLM.
    OrthoDBiEOG7VDXQX.
    TreeFamiTF330814.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR004281. IL-12_alpha.
    [Graphical view]
    PANTHERiPTHR10523. PTHR10523. 1 hit.
    PfamiPF03039. IL12. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G3V780-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCQSRYLLFL ATLVLLNHLT SARVIPVSGP AKCLNQSQNL LKTTDDMVRT    50
    AREKLKHYSC TAGDIDHEDI TRDKTSTLEA CLPLELHKNE SCLATKETSS 100
    IIRGSCLPPQ KTSLMMTLCL GSIYEDLKMY QSEFQAINAA LQSHNHQQIT 150
    LDRNMLMAID ELMQSLNHSG ETLHQKAPMG EADPYRVKMK LCILLHAFST 200
    RVMTINRVMN YLSSS 215
    Length:215
    Mass (Da):24,218
    Last modified:November 16, 2011 - v1
    Checksum:i60EDC00E3B9D5495
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06017963 Genomic DNA. No translation available.
    AABR06017964 Genomic DNA. No translation available.
    CH473976 Genomic DNA. Translation: EDM00915.1.
    CH473976 Genomic DNA. Translation: EDM00916.1.
    UniGeneiRn.207199.

    Genome annotation databases

    EnsembliENSRNOT00000012831; ENSRNOP00000012832; ENSRNOG00000009468.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06017963 Genomic DNA. No translation available.
    AABR06017964 Genomic DNA. No translation available.
    CH473976 Genomic DNA. Translation: EDM00915.1 .
    CH473976 Genomic DNA. Translation: EDM00916.1 .
    UniGenei Rn.207199.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000012831 ; ENSRNOP00000012832 ; ENSRNOG00000009468 .

    Organism-specific databases

    RGDi 620562. Il12a.

    Phylogenomic databases

    GeneTreei ENSGT00390000016906.
    OMAi MNAKLLM.
    OrthoDBi EOG7VDXQX.
    TreeFami TF330814.

    Miscellaneous databases

    NextBioi 35583880.
    PROi G3V780.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR004281. IL-12_alpha.
    [Graphical view ]
    PANTHERi PTHR10523. PTHR10523. 1 hit.
    Pfami PF03039. IL12. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V780_RAT
    AccessioniPrimary (citable) accession number: G3V780
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3