Il12a

Functionⁱ

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.UniRule annotation

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
growth factor activity Source: UniProtKB-KW
interleukin-12 beta subunit binding Source: Ensembl
interleukin-12 receptor binding Source: InterPro
interleukin-27 binding Source: Ensembl
protein heterodimerization activity Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

cell cycle arrest Source: Ensembl
cell migration Source: Ensembl
cellular response to lipopolysaccharide Source: Ensembl
cellular response to virus Source: Ensembl
defense response to Gram-positive bacterium Source: Ensembl
defense response to protozoan Source: Ensembl
extrinsic apoptotic signaling pathway Source: Ensembl
immune response Source: InterPro
negative regulation of interleukin-17 production Source: Ensembl
negative regulation of smooth muscle cell proliferation Source: Ensembl
positive regulation of dendritic cell chemotaxis Source: Ensembl
positive regulation of interferon-gamma production Source: Ensembl
positive regulation of natural killer cell activation Source: Ensembl
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: Ensembl
positive regulation of NK T cell activation Source: Ensembl
positive regulation of smooth muscle cell apoptotic process Source: Ensembl
positive regulation of T cell differentiation Source: Ensembl
positive regulation of T cell mediated cytotoxicity Source: Ensembl
positive regulation of T cell proliferation Source: Ensembl
positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
response to UV-B Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	CytokineUniRule annotation, Growth factorUniRule annotation

Molecular function

CytokineUniRule annotation, Growth factorUniRule annotation

Enzyme and pathway databases

Reactomeⁱ	R-RNO-447115. Interleukin-12 family signaling.

Reactomeⁱ

R-RNO-447115. Interleukin-12 family signaling.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-12 subunit alphaUniRule annotation Short name: IL-12AUniRule annotation
Gene namesⁱ	Name:Il12aImported Synonyms:IL12AUniRule annotation ORF Names:rCG_62487Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 2

Organism-specific databases

Rat genome database More...RGDⁱ	620562. Il12a.

RGDⁱ

620562. Il12a.

Subcellular locationⁱ

Secreted
UniRule annotation
Automatic assertion according to rulesⁱ
- RuleBase:RU363133

GO - Cellular componentⁱ

cytoplasm Source: Ensembl
interleukin-12 complex Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

SecretedUniRule annotation

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	UniRule annotationAdd BLAST		22
ChainⁱPRO_5010395762	23 – 215	Interleukin-12 subunit alphaUniRule annotationAdd BLAST		193

Keywords - PTMⁱ

Disulfide bondUniRule annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000009468.

Bgeeⁱ

ENSRNOG00000009468.

Interactionⁱ

Subunit structureⁱ

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.UniRule annotation

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
growth factor activity Source: UniProtKB-KW
interleukin-12 beta subunit binding Source: Ensembl
interleukin-12 receptor binding Source: InterPro
interleukin-27 binding Source: Ensembl
protein heterodimerization activity Source: Ensembl

Complete GO annotation...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000012832.

STRINGⁱ

10116.ENSRNOP00000012832.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IL-6 superfamily.UniRule annotation

Keywords - Domainⁱ

SignalUniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IVIR. Eukaryota. ENOG410ZGHJ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016906.
OMAⁱ	YPCTSEE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13SK.
TreeFamⁱ	TF330814.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079. 4_helix_cytokine-like_core. IPR004281. IL-12_alpha.
PANTHERⁱ	PTHR10078:SF30. PTHR10078:SF30. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03039. IL12. 1 hit.
SUPFAMⁱ	SSF47266. SSF47266. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

G3V780-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MCQSRYLLFL ATLVLLNHLT SARVIPVSGP AKCLNQSQNL LKTTDDMVRT 
        60         70         80         90        100
AREKLKHYSC TAGDIDHEDI TRDKTSTLEA CLPLELHKNE SCLATKETSS 
       110        120        130        140        150
IIRGSCLPPQ KTSLMMTLCL GSIYEDLKMY QSEFQAINAA LQSHNHQQIT 
       160        170        180        190        200
LDRNMLMAID ELMQSLNHSG ETLHQKAPMG EADPYRVKMK LCILLHAFST 
       210 
RVMTINRVMN YLSSS

Length:215

Mass (Da):24,218

Last modified:November 16, 2011 - v1

Checksum:ⁱ60EDC00E3B9D5495

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07011640 Genomic DNA. No translation available. AABR07011641 Genomic DNA. No translation available. CH473976 Genomic DNA. Translation: EDM00915.1. CH473976 Genomic DNA. Translation: EDM00916.1.
UniGeneⁱ	Rn.207199.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000012831; ENSRNOP00000012832; ENSRNOG00000009468.

Ensemblⁱ

ENSRNOT00000012831; ENSRNOP00000012832; ENSRNOG00000009468.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07011640 Genomic DNA. No translation available. AABR07011641 Genomic DNA. No translation available. CH473976 Genomic DNA. Translation: EDM00915.1. CH473976 Genomic DNA. Translation: EDM00916.1.
UniGeneⁱ	Rn.207199.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000012832.

STRINGⁱ

10116.ENSRNOP00000012832.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000012831; ENSRNOP00000012832; ENSRNOG00000009468.

Ensemblⁱ

ENSRNOT00000012831; ENSRNOP00000012832; ENSRNOG00000009468.

Organism-specific databases

Rat genome database More...RGDⁱ	620562. Il12a.

RGDⁱ

620562. Il12a.

Phylogenomic databases

eggNOGⁱ	ENOG410IVIR. Eukaryota. ENOG410ZGHJ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016906.
OMAⁱ	YPCTSEE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13SK.
TreeFamⁱ	TF330814.

Enzyme and pathway databases

Reactomeⁱ	R-RNO-447115. Interleukin-12 family signaling.

Reactomeⁱ

R-RNO-447115. Interleukin-12 family signaling.

Gene expression databases

Bgeeⁱ	ENSRNOG00000009468.

Bgeeⁱ

ENSRNOG00000009468.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079. 4_helix_cytokine-like_core. IPR004281. IL-12_alpha.
PANTHERⁱ	PTHR10078:SF30. PTHR10078:SF30. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03039. IL12. 1 hit.
SUPFAMⁱ	SSF47266. SSF47266. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G3V780_RAT
Accessionⁱ	G3V780Primary (citable) accession number: G3V780
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 16, 2011
	Last sequence update:	November 16, 2011
	Last modified:	June 7, 2017
	This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - G3V780 (G3V780_RAT)

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Interleukin-12 subunit alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ