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G3V780

- G3V780_RAT

UniProt

G3V780 - G3V780_RAT

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Protein
Submitted name:

Interleukin 12a, isoform CRA_a

Gene

Il12a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Biological processi

  1. cell cycle arrest Source: Ensembl
  2. cell migration Source: Ensembl
  3. defense response to Gram-positive bacterium Source: Ensembl
  4. defense response to protozoan Source: Ensembl
  5. extrinsic apoptotic signaling pathway Source: Ensembl
  6. immune response Source: InterPro
  7. negative regulation of interleukin-17 production Source: Ensembl
  8. negative regulation of smooth muscle cell proliferation Source: Ensembl
  9. positive regulation of cell adhesion Source: Ensembl
  10. positive regulation of interferon-gamma production Source: Ensembl
  11. positive regulation of natural killer cell activation Source: Ensembl
  12. positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: Ensembl
  13. positive regulation of NK T cell activation Source: Ensembl
  14. positive regulation of smooth muscle cell apoptotic process Source: Ensembl
  15. positive regulation of T cell differentiation Source: Ensembl
  16. positive regulation of T cell mediated cytotoxicity Source: Ensembl
  17. positive regulation of T cell proliferation Source: Ensembl
  18. positive regulation of tyrosine phosphorylation of Stat4 protein Source: Ensembl
  19. response to lipopolysaccharide Source: Ensembl
  20. response to UV-B Source: Ensembl
  21. response to virus Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin 12a, isoform CRA_aImported
Submitted name:
Interleukin-12 subunit alphaImported
Gene namesi
Name:Il12aImported
ORF Names:rCG_62487Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi620562. Il12a.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. interleukin-12 complex Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000016906.
OMAiMNAKLLM.
OrthoDBiEOG7VDXQX.
TreeFamiTF330814.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR004281. IL-12_alpha.
[Graphical view]
PANTHERiPTHR10523. PTHR10523. 1 hit.
PfamiPF03039. IL12. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

G3V780-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCQSRYLLFL ATLVLLNHLT SARVIPVSGP AKCLNQSQNL LKTTDDMVRT
60 70 80 90 100
AREKLKHYSC TAGDIDHEDI TRDKTSTLEA CLPLELHKNE SCLATKETSS
110 120 130 140 150
IIRGSCLPPQ KTSLMMTLCL GSIYEDLKMY QSEFQAINAA LQSHNHQQIT
160 170 180 190 200
LDRNMLMAID ELMQSLNHSG ETLHQKAPMG EADPYRVKMK LCILLHAFST
210
RVMTINRVMN YLSSS
Length:215
Mass (Da):24,218
Last modified:November 16, 2011 - v1
Checksum:i60EDC00E3B9D5495
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06017963 Genomic DNA. No translation available.
AABR06017964 Genomic DNA. No translation available.
CH473976 Genomic DNA. Translation: EDM00915.1.
CH473976 Genomic DNA. Translation: EDM00916.1.
UniGeneiRn.207199.

Genome annotation databases

EnsembliENSRNOT00000012831; ENSRNOP00000012832; ENSRNOG00000009468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR06017963 Genomic DNA. No translation available.
AABR06017964 Genomic DNA. No translation available.
CH473976 Genomic DNA. Translation: EDM00915.1 .
CH473976 Genomic DNA. Translation: EDM00916.1 .
UniGenei Rn.207199.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000012831 ; ENSRNOP00000012832 ; ENSRNOG00000009468 .

Organism-specific databases

RGDi 620562. Il12a.

Phylogenomic databases

GeneTreei ENSGT00390000016906.
OMAi MNAKLLM.
OrthoDBi EOG7VDXQX.
TreeFami TF330814.

Miscellaneous databases

NextBioi 35583880.
PROi G3V780.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR004281. IL-12_alpha.
[Graphical view ]
PANTHERi PTHR10523. PTHR10523. 1 hit.
Pfami PF03039. IL12. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiG3V780_RAT
AccessioniPrimary (citable) accession number: G3V780
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 1, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3