UniProtKB - G3V780 (G3V780_RAT)
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Protein
Interleukin-12 subunit alpha
Gene
Il12a
Organism
Rattus norvegicus (Rat)
Status
Functioni
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.UniRule annotation
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- growth factor activity Source: UniProtKB-KW
- interleukin-12 beta subunit binding Source: Ensembl
- interleukin-12 receptor binding Source: InterPro
- interleukin-27 binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
GO - Biological processi
- cell cycle arrest Source: Ensembl
- cell migration Source: Ensembl
- cell proliferation Source: Ensembl
- cellular response to lipopolysaccharide Source: Ensembl
- cellular response to virus Source: Ensembl
- defense response to Gram-positive bacterium Source: Ensembl
- defense response to protozoan Source: Ensembl
- extrinsic apoptotic signaling pathway Source: Ensembl
- interferon-gamma production Source: Ensembl
- negative regulation of interleukin-17 production Source: Ensembl
- negative regulation of smooth muscle cell proliferation Source: Ensembl
- positive regulation of dendritic cell chemotaxis Source: Ensembl
- positive regulation of interferon-gamma production Source: Ensembl
- positive regulation of natural killer cell activation Source: Ensembl
- positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: Ensembl
- positive regulation of NK T cell activation Source: Ensembl
- positive regulation of smooth muscle cell apoptotic process Source: Ensembl
- positive regulation of T cell differentiation Source: Ensembl
- positive regulation of T cell mediated cytotoxicity Source: Ensembl
- positive regulation of T cell proliferation Source: Ensembl
- positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
- response to UV-B Source: Ensembl
- T-helper 1 cell cytokine production Source: Ensembl
Keywordsi
Molecular function | CytokineUniRule annotation, Growth factorUniRule annotation |
Enzyme and pathway databases
Reactomei | R-RNO-8984722. Interleukin-35 Signalling. R-RNO-9020591. Interleukin-12 signaling. |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-12 subunit alphaUniRule annotationShort name: IL-12AUniRule annotation |
Gene namesi | ORF Names:rCG_62487Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620562. Il12a. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | UniRule annotationAdd BLAST | 22 | |
ChainiPRO_5013982455 | 23 – 215 | Interleukin-12 subunit alphaUniRule annotationAdd BLAST | 193 |
Keywords - PTMi
Disulfide bondUniRule annotationInteractioni
Subunit structurei
Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.UniRule annotation
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- growth factor activity Source: UniProtKB-KW
- interleukin-12 beta subunit binding Source: Ensembl
- interleukin-12 receptor binding Source: InterPro
- interleukin-27 binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
Family & Domainsi
Sequence similaritiesi
Belongs to the IL-6 superfamily.UniRule annotation
Keywords - Domaini
SignalUniRule annotationPhylogenomic databases
eggNOGi | ENOG410IVIR. Eukaryota. ENOG410ZGHJ. LUCA. |
GeneTreei | ENSGT00390000016906. |
OMAi | YPCTSEE. |
OrthoDBi | EOG091G13SK. |
TreeFami | TF330814. |
Family and domain databases
InterProi | View protein in InterPro IPR009079. 4_helix_cytokine-like_core. IPR004281. IL-12_alpha. |
PANTHERi | PTHR45311. PTHR45311. 1 hit. |
Pfami | View protein in Pfam PF03039. IL12. 1 hit. |
SUPFAMi | SSF47266. SSF47266. 1 hit. |
i Sequence
Sequence statusi: Complete.
G3V780-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCQSRYLLFL ATLVLLNHLT SARVIPVSGP AKCLNQSQNL LKTTDDMVRT
60 70 80 90 100
AREKLKHYSC TAGDIDHEDI TRDKTSTLEA CLPLELHKNE SCLATKETSS
110 120 130 140 150
IIRGSCLPPQ KTSLMMTLCL GSIYEDLKMY QSEFQAINAA LQSHNHQQIT
160 170 180 190 200
LDRNMLMAID ELMQSLNHSG ETLHQKAPMG EADPYRVKMK LCILLHAFST
210
RVMTINRVMN YLSSS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07011640 Genomic DNA. No translation available. AABR07011641 Genomic DNA. No translation available. CH473976 Genomic DNA. Translation: EDM00915.1. CH473976 Genomic DNA. Translation: EDM00916.1. |
UniGenei | Rn.207199. |
Genome annotation databases
Ensembli | ENSRNOT00000012831; ENSRNOP00000012832; ENSRNOG00000009468. |
Similar proteinsi
Entry informationi
Entry namei | G3V780_RAT | |
Accessioni | G3V780Primary (citable) accession number: G3V780 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | March 28, 2018 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |