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Protein

Interleukin-12 subunit alpha

Gene

Il12a

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionCytokineUniRule annotation, Growth factorUniRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-447115. Interleukin-12 signaling.
R-RNO-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 subunit alphaUniRule annotation
Short name:
IL-12AUniRule annotation
Gene namesi
Name:Il12aImported
Synonyms:IL12AUniRule annotation
ORF Names:rCG_62487Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620562. Il12a.

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22UniRule annotationAdd BLAST22
ChainiPRO_500936685223 – 215Interleukin-12 subunit alphaUniRule annotationAdd BLAST193

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000009468.

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.UniRule annotation

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012832.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410IVIR. Eukaryota.
ENOG410ZGHJ. LUCA.
GeneTreeiENSGT00390000016906.
OMAiNFNSETV.
OrthoDBiEOG091G13SK.
TreeFamiTF330814.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR004281. IL-12_alpha.
PANTHERiPTHR10078:SF30. PTHR10078:SF30. 1 hit.
PfamiView protein in Pfam
PF03039. IL12. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

G3V780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCQSRYLLFL ATLVLLNHLT SARVIPVSGP AKCLNQSQNL LKTTDDMVRT
60 70 80 90 100
AREKLKHYSC TAGDIDHEDI TRDKTSTLEA CLPLELHKNE SCLATKETSS
110 120 130 140 150
IIRGSCLPPQ KTSLMMTLCL GSIYEDLKMY QSEFQAINAA LQSHNHQQIT
160 170 180 190 200
LDRNMLMAID ELMQSLNHSG ETLHQKAPMG EADPYRVKMK LCILLHAFST
210
RVMTINRVMN YLSSS
Length:215
Mass (Da):24,218
Last modified:November 16, 2011 - v1
Checksum:i60EDC00E3B9D5495
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07011640 Genomic DNA. No translation available.
AABR07011641 Genomic DNA. No translation available.
CH473976 Genomic DNA. Translation: EDM00915.1.
CH473976 Genomic DNA. Translation: EDM00916.1.
UniGeneiRn.207199.

Genome annotation databases

EnsembliENSRNOT00000012831; ENSRNOP00000012832; ENSRNOG00000009468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07011640 Genomic DNA. No translation available.
AABR07011641 Genomic DNA. No translation available.
CH473976 Genomic DNA. Translation: EDM00915.1.
CH473976 Genomic DNA. Translation: EDM00916.1.
UniGeneiRn.207199.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012832.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012831; ENSRNOP00000012832; ENSRNOG00000009468.

Organism-specific databases

RGDi620562. Il12a.

Phylogenomic databases

eggNOGiENOG410IVIR. Eukaryota.
ENOG410ZGHJ. LUCA.
GeneTreeiENSGT00390000016906.
OMAiNFNSETV.
OrthoDBiEOG091G13SK.
TreeFamiTF330814.

Enzyme and pathway databases

ReactomeiR-RNO-447115. Interleukin-12 signaling.
R-RNO-6788467. IL-6-type cytokine receptor ligand interactions.

Gene expression databases

BgeeiENSRNOG00000009468.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR004281. IL-12_alpha.
PANTHERiPTHR10078:SF30. PTHR10078:SF30. 1 hit.
PfamiView protein in Pfam
PF03039. IL12. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiG3V780_RAT
AccessioniPrimary (citable) accession number: G3V780
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 15, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.