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G3V746

- G3V746_RAT

UniProt

G3V746 - G3V746_RAT

Protein
Submitted name:

Glutamate receptor ionotropic, NMDA 2B

Gene

Grin2b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium channel activity Source: Ensembl
    2. extracellular-glutamate-gated ion channel activity Source: InterPro
    3. glycine binding Source: Ensembl
    4. N-methyl-D-aspartate selective glutamate receptor activity Source: Ensembl

    GO - Biological processi

    1. behavioral fear response Source: Ensembl
    2. behavioral response to pain Source: Ensembl
    3. detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
    4. in utero embryonic development Source: Ensembl
    5. learning Source: Ensembl
    6. memory Source: Ensembl
    7. regulation of excitatory postsynaptic membrane potential Source: Ensembl
    8. regulation of synaptic plasticity Source: Ensembl
    9. response to ethanol Source: Ensembl
    10. sensory organ development Source: Ensembl
    11. startle response Source: Ensembl
    12. suckling behavior Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196389. Ras activation uopn Ca2+ infux through NMDA receptor.
    REACT_196392. CREB phosphorylation through the activation of CaMKII.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glutamate receptor ionotropic, NMDA 2BImported
    Submitted name:
    Glutamate receptor, ionotropic, N-methyl D-aspartate 2B, isoform CRA_aImported
    Gene namesi
    Name:Grin2bImported
    ORF Names:rCG_29810Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi2738. Grin2b.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. N-methyl-D-aspartate selective glutamate receptor complex Source: Ensembl
    3. postsynaptic density Source: Ensembl
    4. postsynaptic membrane Source: UniProtKB-KW
    5. synaptic vesicle Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00540000070221.
    KOiK05210.
    OMAiCTNRSHL.
    OrthoDBiEOG72ZCD1.
    TreeFamiTF314731.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR018884. NMDAR2_C.
    IPR028082. Peripla_BP_I.
    IPR001638. SBP_bac_3.
    [Graphical view]
    PfamiPF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF10565. NMDAR2_C. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view]
    PRINTSiPR00177. NMDARECEPTOR.
    SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view]
    SUPFAMiSSF53822. SSF53822. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G3V746-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPSAECCSP KFWLVLAVLA VSGSKARSQK SPPSIGIAVI LVGTSDEVAI     50
    KDAHEKDDFH HLSVVPRVEL VAMNETDPKS IITRICDLMS DRKIQGVVFA 100
    DDTDQEAIAQ ILDFISAQTL TPILGIHGGS SMIMADKDES SMFFQFGPSI 150
    EQQASVMLNI MEEYDWYIFS IVTTYFPGYQ DFVNKIRSTI ENSFVGWELE 200
    EVLLLDMSLD DGDSKIQNQL KKLQSPIILL YCTKEEATYI FEVANSVGLT 250
    GYGYTWIVPS LVAGDTDTVP SEFPTGLISV SYDEWDYGLP ARVRDGIAII 300
    TTAASDMLSE HSFIPEPKSS CYNTHEKRIY QSNMLNRYLI NVTFEGRNLS 350
    FSEDGYQMHP KLVIILLNKE RKWERVGKWK DKSLQMKYYV WPRMCPETEE 400
    QEDDHLSIVT LEEAPFVIVE SVDPLSGTCM RNTVPCQKRI ISENKTDEEP 450
    GYIKKCCKGF CIDILKKISK SVKFTYDLYL VTNGKHGKKI NGTWNGMIGE 500
    VVMKRAYMAV GSLTINEERS EVVDFSVPFI ETGISVMVSR SNGTVSPSAF 550
    LEPFSADVWV MMFVMLLIVS AVAVFVFEYF SPVGYNRCLA DGREPGGPSF 600
    TIGKAIWLLW GLVFNNSVPV QNPKGTTSKI MVSVWAFFAV IFLASYTANL 650
    AAFMIQEEYV DQVSGLSDKK FQRPNDFSPP FRFGTVPNGS TERNIRNNYA 700
    EMHAYMGKFN QRGVDDALLS LKTGKLDAFI YDAAVLNYMA GRDEGCKLVT 750
    IGSGKVFAST GYGIAIQKDS GWKRQVDLAI LQLFGDGEME ELEALWLTGI 800
    CHNEKNEVMS SQLDIDNMAG VFYMLGAAMA LSLITFICEH LFYWQFRHCF 850
    MGVCSGKPGM VFSISRGIYS CIHGVAIEER QSVMNSPTAT MNNTHSNILR 900
    LLRTAKNMAN LSGVNGSPQS ALDFIRRESS VYDISEHRRS FTHSDCKSYN 950
    NPPCEENLFS DYISEVERTF GNLQLKDSNV YQDHYHHHHR PHSIGSTSSI 1000
    DGLYDCDNPP FTTQPRSISK KPLDIGLPSS KHSQLSDLYG KFSFKSDRYS 1050
    GHDDLIRSDV SDISTHTVTY GNIEGNAAKR RKQQYKDSLK KRPASAKSRR 1100
    EFDEIELAYR RRPPRSPDHK RYFRDKEGLR DFYLDQFRTK ENSPHWEHVD 1150
    LTDIYKERSD DFKRDSVSGG GPCTNRSHLK HGTGEKHGVV GGVPAPWEKN 1200
    LTNVDWEDRS GGNFCRSCPS KLHNYSSTVA GQNSGRQACI RCEACKKAGN 1250
    LYDISEDNSL QELDQPAAPV AVTSNASSTK YPQSPTNSKA QKKNRNKLRR 1300
    QHSYDTFVDL QKEEAALAPR SVSLKDKGRF MDGSPYAHMF EMPAGESSFA 1350
    NKSSVPTAGH HHNNPGSGYM LSKSLYPDRV TQNPFIPTFG DDQCLLHGSK 1400
    SYFFRQPTVA GASKTRPDFR ALVTNKPVVS ALHGAVPGRF QKDICIGNQS 1450
    NPCVPNNKNP RAFNGSSNGH VYEKLSSIES DV 1482
    Length:1,482
    Mass (Da):166,029
    Last modified:November 16, 2011 - v1
    Checksum:i5BF8B9C58AC6A130
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06033915 Genomic DNA. No translation available.
    AABR06033916 Genomic DNA. No translation available.
    AABR06033917 Genomic DNA. No translation available.
    AABR06033918 Genomic DNA. No translation available.
    AABR06033919 Genomic DNA. No translation available.
    AABR06033920 Genomic DNA. No translation available.
    AABR06033921 Genomic DNA. No translation available.
    AABR06033922 Genomic DNA. No translation available.
    AABR06033923 Genomic DNA. No translation available.
    AABR06033924 Genomic DNA. No translation available.
    AABR06033925 Genomic DNA. No translation available.
    AABR06033926 Genomic DNA. No translation available.
    CH473964 Genomic DNA. Translation: EDM01617.1.
    CH473964 Genomic DNA. Translation: EDM01618.1.
    RefSeqiXP_006237574.1. XM_006237512.1.
    XP_006237575.1. XM_006237513.1.
    UniGeneiRn.9711.

    Genome annotation databases

    EnsembliENSRNOT00000011697; ENSRNOP00000011697; ENSRNOG00000008766.
    GeneIDi24410.
    KEGGirno:24410.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06033915 Genomic DNA. No translation available.
    AABR06033916 Genomic DNA. No translation available.
    AABR06033917 Genomic DNA. No translation available.
    AABR06033918 Genomic DNA. No translation available.
    AABR06033919 Genomic DNA. No translation available.
    AABR06033920 Genomic DNA. No translation available.
    AABR06033921 Genomic DNA. No translation available.
    AABR06033922 Genomic DNA. No translation available.
    AABR06033923 Genomic DNA. No translation available.
    AABR06033924 Genomic DNA. No translation available.
    AABR06033925 Genomic DNA. No translation available.
    AABR06033926 Genomic DNA. No translation available.
    CH473964 Genomic DNA. Translation: EDM01617.1 .
    CH473964 Genomic DNA. Translation: EDM01618.1 .
    RefSeqi XP_006237574.1. XM_006237512.1.
    XP_006237575.1. XM_006237513.1.
    UniGenei Rn.9711.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011697 ; ENSRNOP00000011697 ; ENSRNOG00000008766 .
    GeneIDi 24410.
    KEGGi rno:24410.

    Organism-specific databases

    CTDi 2904.
    RGDi 2738. Grin2b.

    Phylogenomic databases

    GeneTreei ENSGT00540000070221.
    KOi K05210.
    OMAi CTNRSHL.
    OrthoDBi EOG72ZCD1.
    TreeFami TF314731.

    Enzyme and pathway databases

    Reactomei REACT_196389. Ras activation uopn Ca2+ infux through NMDA receptor.
    REACT_196392. CREB phosphorylation through the activation of CaMKII.

    Miscellaneous databases

    NextBioi 35583860.
    PROi G3V746.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR018884. NMDAR2_C.
    IPR028082. Peripla_BP_I.
    IPR001638. SBP_bac_3.
    [Graphical view ]
    Pfami PF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF10565. NMDAR2_C. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00177. NMDARECEPTOR.
    SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53822. SSF53822. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V746_RAT
    AccessioniPrimary (citable) accession number: G3V746
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3