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G3V740

- G3V740_RAT

UniProt

G3V740 - G3V740_RAT

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Protein
Submitted name: Homeobox protein Nkx-2.1
Gene
Nkx2-1, rCG_62381
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
  2. sequence-specific DNA binding Source: Ensembl
  3. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. Clara cell differentiation Source: Ensembl
  2. Leydig cell differentiation Source: Ensembl
  3. Type II pneumocyte differentiation Source: Ensembl
  4. anatomical structure formation involved in morphogenesis Source: Ensembl
  5. axon guidance Source: Ensembl
  6. cerebral cortex GABAergic interneuron differentiation Source: Ensembl
  7. cerebral cortex cell migration Source: Ensembl
  8. developmental induction Source: Ensembl
  9. endoderm development Source: Ensembl
  10. epithelial tube branching involved in lung morphogenesis Source: Ensembl
  11. forebrain dorsal/ventral pattern formation Source: Ensembl
  12. forebrain neuron fate commitment Source: Ensembl
  13. globus pallidus development Source: Ensembl
  14. hippocampus development Source: Ensembl
  15. locomotory behavior Source: Ensembl
  16. lung saccule development Source: Ensembl
  17. menarche Source: Ensembl
  18. negative regulation of cell migration Source: Ensembl
  19. negative regulation of epithelial to mesenchymal transition Source: Ensembl
  20. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  21. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  22. neuron migration Source: Ensembl
  23. oligodendrocyte differentiation Source: Ensembl
  24. phospholipid metabolic process Source: Ensembl
  25. pituitary gland development Source: Ensembl
  26. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  27. response to hormone Source: Ensembl
  28. thyroid gland development Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox protein Nkx-2.1Imported
Submitted name:
RCG62381Imported
Gene namesi
Name:Nkx2-1Imported
ORF Names:rCG_62381Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi3866. Nkx2-1.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains homeobox DNA-binding domain.SAAS annotations

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00720000108380.
KOiK09342.
OMAiKSMAPLQ.
OrthoDBiEOG769ZK0.
TreeFamiTF351204.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V740-1 [UniParc]FASTAAdd to Basket

« Hide

MSMSPKHTTP FSVSDILSPL EESYKKVGME GGGLGAPLAA YRQGQAAPPA    50
AAMQQHAVGH HGAVTAAYHM TAAGVPQLSH SAVGGYCNGN LGNVSELPPY 100
QDTMRNSASG PGWYGANPDP RFPAISRFMG PASGMNMSGM GGLGSLGDVS 150
KNMAPLPSAP RRKRRVLFSQ AQVYELERRF KQQKYLSAPE REHLASMIHL 200
TPTQVKIWFQ NHRYKMKRQA KDKAAQQQLQ QDSGGGGGGG GGAGCPQQQQ 250
AQQQSPRRVA VPVLVKDGKP CQAGAPAPGA ASLQGHAQQQ AQQQAQAAQA 300
AAAAISVGSG GAGLGAHPGH QPGSAGQSPD LAHHAASPAA LQGQVSSLSH 350
LNSSGSDYGA MSCSTLLYGR TW 372
Length:372
Mass (Da):38,522
Last modified:November 16, 2011 - v1
Checksum:iEB534DB8580D4520
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06044173 Genomic DNA. No translation available.
CH473947 Genomic DNA. Translation: EDM03442.1.
RefSeqiNP_037225.1. NM_013093.1.
XP_006240180.1. XM_006240118.1.
UniGeneiRn.34265.

Genome annotation databases

EnsembliENSRNOT00000011453; ENSRNOP00000011453; ENSRNOG00000008644.
GeneIDi25628.
KEGGirno:25628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06044173 Genomic DNA. No translation available.
CH473947 Genomic DNA. Translation: EDM03442.1 .
RefSeqi NP_037225.1. NM_013093.1.
XP_006240180.1. XM_006240118.1.
UniGenei Rn.34265.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011453 ; ENSRNOP00000011453 ; ENSRNOG00000008644 .
GeneIDi 25628.
KEGGi rno:25628.

Organism-specific databases

CTDi 7080.
RGDi 3866. Nkx2-1.

Phylogenomic databases

GeneTreei ENSGT00720000108380.
KOi K09342.
OMAi KSMAPLQ.
OrthoDBi EOG769ZK0.
TreeFami TF351204.

Miscellaneous databases

NextBioi 607421.
PROi G3V740.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiG3V740_RAT
AccessioniPrimary (citable) accession number: G3V740
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: May 14, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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