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G3V740

- G3V740_RAT

UniProt

G3V740 - G3V740_RAT

Protein
Submitted name:

Homeobox protein Nkx-2.1

Gene

Nkx2-1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    2. sequence-specific DNA binding Source: Ensembl
    3. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. anatomical structure formation involved in morphogenesis Source: Ensembl
    2. axon guidance Source: Ensembl
    3. cerebral cortex cell migration Source: Ensembl
    4. cerebral cortex GABAergic interneuron differentiation Source: Ensembl
    5. Clara cell differentiation Source: Ensembl
    6. developmental induction Source: Ensembl
    7. endoderm development Source: Ensembl
    8. epithelial tube branching involved in lung morphogenesis Source: Ensembl
    9. forebrain dorsal/ventral pattern formation Source: Ensembl
    10. forebrain neuron fate commitment Source: Ensembl
    11. globus pallidus development Source: Ensembl
    12. hippocampus development Source: Ensembl
    13. Leydig cell differentiation Source: Ensembl
    14. locomotory behavior Source: Ensembl
    15. lung saccule development Source: Ensembl
    16. menarche Source: Ensembl
    17. negative regulation of cell migration Source: Ensembl
    18. negative regulation of epithelial to mesenchymal transition Source: Ensembl
    19. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    20. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    21. neuron migration Source: Ensembl
    22. oligodendrocyte differentiation Source: Ensembl
    23. phospholipid metabolic process Source: Ensembl
    24. pituitary gland development Source: Ensembl
    25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    26. response to hormone Source: Ensembl
    27. thyroid gland development Source: Ensembl
    28. Type II pneumocyte differentiation Source: Ensembl

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Homeobox protein Nkx-2.1Imported
    Submitted name:
    RCG62381Imported
    Gene namesi
    Name:Nkx2-1Imported
    ORF Names:rCG_62381Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi3866. Nkx2-1.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains homeobox DNA-binding domain.SAAS annotation

    Keywords - Domaini

    HomeoboxUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00720000108380.
    KOiK09342.
    OMAiKSMAPLQ.
    OrthoDBiEOG769ZK0.
    TreeFamiTF351204.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3V740-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSMSPKHTTP FSVSDILSPL EESYKKVGME GGGLGAPLAA YRQGQAAPPA    50
    AAMQQHAVGH HGAVTAAYHM TAAGVPQLSH SAVGGYCNGN LGNVSELPPY 100
    QDTMRNSASG PGWYGANPDP RFPAISRFMG PASGMNMSGM GGLGSLGDVS 150
    KNMAPLPSAP RRKRRVLFSQ AQVYELERRF KQQKYLSAPE REHLASMIHL 200
    TPTQVKIWFQ NHRYKMKRQA KDKAAQQQLQ QDSGGGGGGG GGAGCPQQQQ 250
    AQQQSPRRVA VPVLVKDGKP CQAGAPAPGA ASLQGHAQQQ AQQQAQAAQA 300
    AAAAISVGSG GAGLGAHPGH QPGSAGQSPD LAHHAASPAA LQGQVSSLSH 350
    LNSSGSDYGA MSCSTLLYGR TW 372
    Length:372
    Mass (Da):38,522
    Last modified:November 16, 2011 - v1
    Checksum:iEB534DB8580D4520
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06044173 Genomic DNA. No translation available.
    CH473947 Genomic DNA. Translation: EDM03442.1.
    RefSeqiNP_037225.1. NM_013093.1.
    XP_006240180.1. XM_006240118.1.
    UniGeneiRn.34265.

    Genome annotation databases

    EnsembliENSRNOT00000011453; ENSRNOP00000011453; ENSRNOG00000008644.
    GeneIDi25628.
    KEGGirno:25628.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06044173 Genomic DNA. No translation available.
    CH473947 Genomic DNA. Translation: EDM03442.1 .
    RefSeqi NP_037225.1. NM_013093.1.
    XP_006240180.1. XM_006240118.1.
    UniGenei Rn.34265.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011453 ; ENSRNOP00000011453 ; ENSRNOG00000008644 .
    GeneIDi 25628.
    KEGGi rno:25628.

    Organism-specific databases

    CTDi 7080.
    RGDi 3866. Nkx2-1.

    Phylogenomic databases

    GeneTreei ENSGT00720000108380.
    KOi K09342.
    OMAi KSMAPLQ.
    OrthoDBi EOG769ZK0.
    TreeFami TF351204.

    Miscellaneous databases

    NextBioi 607421.
    PROi G3V740.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V740_RAT
    AccessioniPrimary (citable) accession number: G3V740
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3