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G3V736

- G3V736_RAT

UniProt

G3V736 - G3V736_RAT

Protein
Submitted name:

Smoothened homolog

Gene

Smo

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. drug binding Source: Ensembl
    2. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. atrial septum morphogenesis Source: Ensembl
    2. cell fate specification Source: Ensembl
    3. cellular response to cholesterol Source: Ensembl
    4. central nervous system neuron differentiation Source: Ensembl
    5. cerebellar cortex morphogenesis Source: Ensembl
    6. detection of cell density by contact stimulus involved in contact inhibition Source: Ensembl
    7. determination of left/right asymmetry in lateral mesoderm Source: Ensembl
    8. developmental growth Source: Ensembl
    9. dorsal/ventral neural tube patterning Source: Ensembl
    10. epithelial-mesenchymal cell signaling Source: Ensembl
    11. forebrain morphogenesis Source: Ensembl
    12. hair follicle morphogenesis Source: Ensembl
    13. heart looping Source: Ensembl
    14. in utero embryonic development Source: Ensembl
    15. mammary gland epithelial cell differentiation Source: Ensembl
    16. mesenchymal to epithelial transition involved in metanephric renal vesicle formation Source: Ensembl
    17. midgut development Source: Ensembl
    18. multicellular organism growth Source: Ensembl
    19. negative regulation of apoptotic process Source: Ensembl
    20. negative regulation of DNA binding Source: Ensembl
    21. negative regulation of epithelial cell differentiation Source: Ensembl
    22. negative regulation of hair follicle development Source: Ensembl
    23. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    24. neural crest cell migration Source: Ensembl
    25. odontogenesis of dentin-containing tooth Source: Ensembl
    26. osteoblast differentiation Source: Ensembl
    27. pancreas morphogenesis Source: Ensembl
    28. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
    29. positive regulation of epithelial cell proliferation Source: Ensembl
    30. positive regulation of hh target transcription factor activity Source: Ensembl
    31. positive regulation of mesenchymal cell proliferation Source: Ensembl
    32. positive regulation of neuroblast proliferation Source: Ensembl
    33. positive regulation of protein import into nucleus Source: Ensembl
    34. positive regulation of smoothened signaling pathway Source: Ensembl
    35. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    36. protein localization to nucleus Source: Ensembl
    37. protein stabilization Source: Ensembl
    38. regulation of heart morphogenesis Source: Ensembl
    39. regulation of stem cell maintenance Source: Ensembl
    40. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: Ensembl
    41. smoothened signaling pathway involved in ventral spinal cord patterning Source: Ensembl
    42. somite development Source: Ensembl
    43. thalamus development Source: Ensembl
    44. type B pancreatic cell development Source: Ensembl
    45. vasculogenesis Source: Ensembl
    46. ventral midline determination Source: Ensembl

    Keywords - Molecular functioni

    Developmental proteinSAAS annotation, ReceptorSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Smoothened homologImported
    Submitted name:
    Smoothened homolog (Drosophila)Imported
    Gene namesi
    Name:SmoImported
    ORF Names:rCG_28227Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi3726. Smo.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: Ensembl
    2. ciliary membrane Source: Ensembl
    3. Golgi apparatus Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. primary cilium Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains FZ (frizzled) domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117492.
    OMAiEVCPLAP.
    OrthoDBiEOG74J972.
    TreeFamiTF106460.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    IPR026544. SMO.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF35. PTHR11309:SF35. 1 hit.
    PfamiPF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view]
    PRINTSiPR00489. FRIZZLED.
    SMARTiSM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3V736-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAGRPVRGP ELAPRRLLQL LLLVLLGGRG RGAALSGNVT GPGPRSAGGS    50
    ARRNAPVTSP PPPLLSHCGR AAHCEPLRYN VCLGSALPYG ATTTLLAGDS 100
    DSQEEAHSKL VLWSGLRNAP RCWAVIQPLL CAVYMPKCEN DRVELPSRTL 150
    CQATRGPCAI VERERGWPDF LRCMPDHFPE GCPNEVQNIK FNSSGQCEAP 200
    LVRTDNPKSW YEDVEGCGIQ CQNPLFTEAE HQDMHSYIAA FGAVTGLCTL 250
    FTLATFVADW RNSNRYPAVI LFYVNACFFV GSIGWLAQFM DGARREIVCR 300
    ADGTMRFGEP TSSETLSCVI IFVIVYYALM AGVVWFVVLT YAWHTSFKAL 350
    GTTYQPLSGK TSYFHLLTWS LPFVLTVAIL AVAQVDGDSV SGICFVGYKN 400
    YRYRAGFVLA PIGLVLIVGG YFLIRGVMTL FSIKSNHPGL LSEKAASKIN 450
    ETMLRLGIFG FLAFGFVLIT FSCHFYDFFN QAEWERSFRD YVLCQANVTI 500
    GLPTKKPIPD CEIKNRPSLL VEKINLFAMF GTGIAMSTWV WTKATLLIWR 550
    RTWCRLTGHS DDEPKRIKKS KMIAKAFSKR RELLQNPGQE LSFSMHTVSH 600
    DGPVAGLAFE LNEPSADVSS AWAQHVTKMV ARRGAILPQD VSVTPVATPV 650
    PPEEQANLWL VEAEISPELE KRLGRKKKRR KRKKEVCPLG PAPELHHSAP 700
    VPATSAVPRL PQLPRQKCLV AANAWGTGEP CRQGAWTVVS NPFCPEPSPH 750
    QDPFLPGASA PRVWAQGRLQ GLGSIHSRTN LMEAELLDAD SDF 793
    Length:793
    Mass (Da):87,406
    Last modified:November 16, 2011 - v1
    Checksum:i1CD233696A76F033
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06030202 Genomic DNA. No translation available.
    CH473959 Genomic DNA. Translation: EDM15233.1.
    UniGeneiRn.44429.

    Genome annotation databases

    EnsembliENSRNOT00000011356; ENSRNOP00000011356; ENSRNOG00000008332.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06030202 Genomic DNA. No translation available.
    CH473959 Genomic DNA. Translation: EDM15233.1 .
    UniGenei Rn.44429.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011356 ; ENSRNOP00000011356 ; ENSRNOG00000008332 .

    Organism-specific databases

    RGDi 3726. Smo.

    Phylogenomic databases

    GeneTreei ENSGT00750000117492.
    OMAi EVCPLAP.
    OrthoDBi EOG74J972.
    TreeFami TF106460.

    Miscellaneous databases

    NextBioi 35583855.
    PROi G3V736.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR000539. Frizzled.
    IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR017981. GPCR_2-like.
    IPR026544. SMO.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    PTHR11309:SF35. PTHR11309:SF35. 1 hit.
    Pfami PF01534. Frizzled. 1 hit.
    PF01392. Fz. 1 hit.
    [Graphical view ]
    PRINTSi PR00489. FRIZZLED.
    SMARTi SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V736_RAT
    AccessioniPrimary (citable) accession number: G3V736
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3