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G3V736

- G3V736_RAT

UniProt

G3V736 - G3V736_RAT

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Protein
Submitted name:

Smoothened homolog

Gene
Smo, rCG_28227
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. drug binding Source: Ensembl
  2. G-protein coupled receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. atrial septum morphogenesis Source: Ensembl
  2. cell fate specification Source: Ensembl
  3. cellular response to cholesterol Source: Ensembl
  4. central nervous system neuron differentiation Source: Ensembl
  5. cerebellar cortex morphogenesis Source: Ensembl
  6. detection of cell density by contact stimulus involved in contact inhibition Source: Ensembl
  7. determination of left/right asymmetry in lateral mesoderm Source: Ensembl
  8. developmental growth Source: Ensembl
  9. dorsal/ventral neural tube patterning Source: Ensembl
  10. epithelial-mesenchymal cell signaling Source: Ensembl
  11. forebrain morphogenesis Source: Ensembl
  12. hair follicle morphogenesis Source: Ensembl
  13. heart looping Source: Ensembl
  14. in utero embryonic development Source: Ensembl
  15. mammary gland epithelial cell differentiation Source: Ensembl
  16. mesenchymal to epithelial transition involved in metanephric renal vesicle formation Source: Ensembl
  17. midgut development Source: Ensembl
  18. multicellular organism growth Source: Ensembl
  19. negative regulation of apoptotic process Source: Ensembl
  20. negative regulation of DNA binding Source: Ensembl
  21. negative regulation of epithelial cell differentiation Source: Ensembl
  22. negative regulation of hair follicle development Source: Ensembl
  23. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  24. neural crest cell migration Source: Ensembl
  25. odontogenesis of dentin-containing tooth Source: Ensembl
  26. osteoblast differentiation Source: Ensembl
  27. pancreas morphogenesis Source: Ensembl
  28. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
  29. positive regulation of epithelial cell proliferation Source: Ensembl
  30. positive regulation of hh target transcription factor activity Source: Ensembl
  31. positive regulation of mesenchymal cell proliferation Source: Ensembl
  32. positive regulation of neuroblast proliferation Source: Ensembl
  33. positive regulation of protein import into nucleus Source: Ensembl
  34. positive regulation of smoothened signaling pathway Source: Ensembl
  35. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  36. protein localization to nucleus Source: Ensembl
  37. protein stabilization Source: Ensembl
  38. regulation of heart morphogenesis Source: Ensembl
  39. regulation of stem cell maintenance Source: Ensembl
  40. smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: Ensembl
  41. smoothened signaling pathway involved in ventral spinal cord patterning Source: Ensembl
  42. somite development Source: Ensembl
  43. thalamus development Source: Ensembl
  44. type B pancreatic cell development Source: Ensembl
  45. vasculogenesis Source: Ensembl
  46. ventral midline determination Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinSAAS annotations, ReceptorSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Smoothened homologImported
Submitted name:
Smoothened homolog (Drosophila)Imported
Gene namesi
Name:SmoImported
ORF Names:rCG_28227Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi3726. Smo.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. ciliary membrane Source: Ensembl
  3. Golgi apparatus Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. primary cilium Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains FZ (frizzled) domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117492.
OMAiEVCPLAP.
OrthoDBiEOG74J972.
TreeFamiTF106460.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR017981. GPCR_2-like.
IPR026544. SMO.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF35. PTHR11309:SF35. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V736-1 [UniParc]FASTAAdd to Basket

« Hide

MAAGRPVRGP ELAPRRLLQL LLLVLLGGRG RGAALSGNVT GPGPRSAGGS    50
ARRNAPVTSP PPPLLSHCGR AAHCEPLRYN VCLGSALPYG ATTTLLAGDS 100
DSQEEAHSKL VLWSGLRNAP RCWAVIQPLL CAVYMPKCEN DRVELPSRTL 150
CQATRGPCAI VERERGWPDF LRCMPDHFPE GCPNEVQNIK FNSSGQCEAP 200
LVRTDNPKSW YEDVEGCGIQ CQNPLFTEAE HQDMHSYIAA FGAVTGLCTL 250
FTLATFVADW RNSNRYPAVI LFYVNACFFV GSIGWLAQFM DGARREIVCR 300
ADGTMRFGEP TSSETLSCVI IFVIVYYALM AGVVWFVVLT YAWHTSFKAL 350
GTTYQPLSGK TSYFHLLTWS LPFVLTVAIL AVAQVDGDSV SGICFVGYKN 400
YRYRAGFVLA PIGLVLIVGG YFLIRGVMTL FSIKSNHPGL LSEKAASKIN 450
ETMLRLGIFG FLAFGFVLIT FSCHFYDFFN QAEWERSFRD YVLCQANVTI 500
GLPTKKPIPD CEIKNRPSLL VEKINLFAMF GTGIAMSTWV WTKATLLIWR 550
RTWCRLTGHS DDEPKRIKKS KMIAKAFSKR RELLQNPGQE LSFSMHTVSH 600
DGPVAGLAFE LNEPSADVSS AWAQHVTKMV ARRGAILPQD VSVTPVATPV 650
PPEEQANLWL VEAEISPELE KRLGRKKKRR KRKKEVCPLG PAPELHHSAP 700
VPATSAVPRL PQLPRQKCLV AANAWGTGEP CRQGAWTVVS NPFCPEPSPH 750
QDPFLPGASA PRVWAQGRLQ GLGSIHSRTN LMEAELLDAD SDF 793
Length:793
Mass (Da):87,406
Last modified:November 16, 2011 - v1
Checksum:i1CD233696A76F033
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06030202 Genomic DNA. No translation available.
CH473959 Genomic DNA. Translation: EDM15233.1.
UniGeneiRn.44429.

Genome annotation databases

EnsembliENSRNOT00000011356; ENSRNOP00000011356; ENSRNOG00000008332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06030202 Genomic DNA. No translation available.
CH473959 Genomic DNA. Translation: EDM15233.1 .
UniGenei Rn.44429.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011356 ; ENSRNOP00000011356 ; ENSRNOG00000008332 .

Organism-specific databases

RGDi 3726. Smo.

Phylogenomic databases

GeneTreei ENSGT00750000117492.
OMAi EVCPLAP.
OrthoDBi EOG74J972.
TreeFami TF106460.

Miscellaneous databases

NextBioi 35583855.
PROi G3V736.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR017981. GPCR_2-like.
IPR026544. SMO.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF35. PTHR11309:SF35. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiG3V736_RAT
AccessioniPrimary (citable) accession number: G3V736
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: July 9, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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