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G3V6N0

- G3V6N0_RAT

UniProt

G3V6N0 - G3V6N0_RAT

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Protein
Submitted name: Adenylate cyclase 8, isoform CRA_a
Gene
Adcy8, rCG_60206
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. adenylate cyclase activity Source: Ensembl
  2. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. long-term memory Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotations

Keywords - Ligandi

Nucleotide-bindingSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_196394. CREB phosphorylation through the activation of Adenylate Cyclase.

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclase 8, isoform CRA_aImported
Submitted name:
Adenylate cyclase type 8Imported
Gene namesi
Name:Adcy8Imported
ORF Names:rCG_60206Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi2036. Adcy8.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00680000099709.
OMAiDVRCLSG.
OrthoDBiEOG7B8S30.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V6N0-1 [UniParc]FASTAAdd to Basket

« Hide

MELSDVHCLS GSEELYTIHP TPPAGDGGSG SRPQRLLWQT AVRHITEQRF     50
IHGHRGGGGG GSRKASNPAG SGPNHHAPQL SSDSVLPLYS LGSGERAHNT 100
GGTKVFPERS GSGSASGSGG GGDLGFLHLD CAPSNSDFFL NGGYSYRGVI 150
FPTLRNSFKS RDLERLYQRY FLGQRRKSEV VMNVLDVLTK LTLLVLHLSL 200
ASAPMDPLKG ILLGFFTGIE VVICALVVVR KDTTSHTYLQ YSGVVTWVAM 250
TTQILAAGLG YGLLGDGIGY VLFTLFATYS MLPLPLTWAI LAGLGTSLLQ 300
VTLQVLIPRL AVFSINQVLA QVVLFMCMNT AGIFISYLSD RAQRQAFLET 350
RRCVEARLRL ETENQRQERL VLSVLPRFVV LEMINDMTNV EDEHLQHQFH 400
RIYIHRYENV SILFADVKGF TNLSTTLSAQ ELVRMLNELF ARFDRLAHEH 450
HCLRIKILGD CYYCVSGLPE PRQDHAHCCV EMGLSMIKTI RFVRSRTKHD 500
VDMRIGIHSG SVLCGVLGLR KWQFDVWSWD VDIANKLESG GIPGRIHISK 550
ATLDCLSGDY NVEEGHGKER NEFLRKHNIE TYLIKQPEES LLSLPEDIVK 600
ESVSCSDRRN SGATFTEGSW SPELPFDNIV GKQNTLAALT RNSINLLPNH 650
LAQALHVQSG PEEINKRIEH TIDLRSGDKL RREHIKPFSL MFKDSSLEHK 700
YSQMRDEVFK SNLVCAFIVL LFITAIQSLL PSSRLMPMTI QFSILIMLHS 750
ALVLITTAED YKCLPLILRK TCCWINETYL ARNVIIFASI LINFLGAVIN 800
ILWCDFDKSI PLKNLTFNSS AVFTDICSYP EYFVFTGVLA MVTCAVFLRL 850
NSVLKLAVLL IMIAIYALLT ETIYAGLFLS YDNLNHSGED FLGTKEASLL 900
LMAMFLLAVF YHGQQLEYTA RLDFLWRVQA KEEINEMKDL REHNENMLRN 950
ILPGHVARHF LEKDRDNEEL YSQSYDAVGV MFASIPGFAD FYSQTEMNNQ 1000
GVECLRLLNE IIADFDELLG EDRFQDIEKI KTIGSTYMAV SGLSPEKQQC 1050
EDKWGHLCAL ADFSLALTES IQEINKHSFN NFELRIGISH GSVVAGVIGA 1100
KKPQYDIWGK TVNLASRMDS TGVSGRIQVP EETYLILKDQ GFAFDYRGEI 1150
YVKGISEQEG KIKTYFLLGR VQPNPFILPP RRLPGQYSLA AVVLGLVQSL 1200
NRQRQKQLLN ENSNSGIIKS HYNRRTLLTP SGPEPGAQAE GTDKSDLP 1248
Length:1,248
Mass (Da):139,809
Last modified:November 16, 2011 - v1
Checksum:iE050BBF609648E9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06051492 Genomic DNA. No translation available.
AABR06051493 Genomic DNA. No translation available.
AABR06051494 Genomic DNA. No translation available.
AABR06051495 Genomic DNA. No translation available.
AABR06051496 Genomic DNA. No translation available.
AABR06051497 Genomic DNA. No translation available.
AABR06051498 Genomic DNA. No translation available.
AABR06051499 Genomic DNA. No translation available.
CH473950 Genomic DNA. Translation: EDM16168.1.
UniGeneiRn.10382.

Genome annotation databases

EnsembliENSRNOT00000006789; ENSRNOP00000006789; ENSRNOG00000004890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06051492 Genomic DNA. No translation available.
AABR06051493 Genomic DNA. No translation available.
AABR06051494 Genomic DNA. No translation available.
AABR06051495 Genomic DNA. No translation available.
AABR06051496 Genomic DNA. No translation available.
AABR06051497 Genomic DNA. No translation available.
AABR06051498 Genomic DNA. No translation available.
AABR06051499 Genomic DNA. No translation available.
CH473950 Genomic DNA. Translation: EDM16168.1 .
UniGenei Rn.10382.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006789 ; ENSRNOP00000006789 ; ENSRNOG00000004890 .

Organism-specific databases

RGDi 2036. Adcy8.

Phylogenomic databases

GeneTreei ENSGT00680000099709.
OMAi DVRCLSG.
OrthoDBi EOG7B8S30.
TreeFami TF313845.

Enzyme and pathway databases

Reactomei REACT_196394. CREB phosphorylation through the activation of Adenylate Cyclase.

Miscellaneous databases

NextBioi 35583762.
PROi G3V6N0.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view ]
Pfami PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiG3V6N0_RAT
AccessioniPrimary (citable) accession number: G3V6N0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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