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G3V6N0

- G3V6N0_RAT

UniProt

G3V6N0 - G3V6N0_RAT

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Protein
Submitted name:

Adenylate cyclase 8, isoform CRA_a

Gene

Adcy8

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 1 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. adenylate cyclase activity Source: Ensembl
  2. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. long-term memory Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Ligandi

Nucleotide-bindingSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_196394. CREB phosphorylation through the activation of Adenylate Cyclase.

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclase 8, isoform CRA_aImported
Submitted name:
Adenylate cyclase type 8Imported
Gene namesi
Name:Adcy8Imported
ORF Names:rCG_60206Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi2036. Adcy8.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119042.
OMAiDVRCLSG.
OrthoDBiEOG7B8S30.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V6N0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELSDVHCLS GSEELYTIHP TPPAGDGGSG SRPQRLLWQT AVRHITEQRF
60 70 80 90 100
IHGHRGGGGG GSRKASNPAG SGPNHHAPQL SSDSVLPLYS LGSGERAHNT
110 120 130 140 150
GGTKVFPERS GSGSASGSGG GGDLGFLHLD CAPSNSDFFL NGGYSYRGVI
160 170 180 190 200
FPTLRNSFKS RDLERLYQRY FLGQRRKSEV VMNVLDVLTK LTLLVLHLSL
210 220 230 240 250
ASAPMDPLKG ILLGFFTGIE VVICALVVVR KDTTSHTYLQ YSGVVTWVAM
260 270 280 290 300
TTQILAAGLG YGLLGDGIGY VLFTLFATYS MLPLPLTWAI LAGLGTSLLQ
310 320 330 340 350
VTLQVLIPRL AVFSINQVLA QVVLFMCMNT AGIFISYLSD RAQRQAFLET
360 370 380 390 400
RRCVEARLRL ETENQRQERL VLSVLPRFVV LEMINDMTNV EDEHLQHQFH
410 420 430 440 450
RIYIHRYENV SILFADVKGF TNLSTTLSAQ ELVRMLNELF ARFDRLAHEH
460 470 480 490 500
HCLRIKILGD CYYCVSGLPE PRQDHAHCCV EMGLSMIKTI RFVRSRTKHD
510 520 530 540 550
VDMRIGIHSG SVLCGVLGLR KWQFDVWSWD VDIANKLESG GIPGRIHISK
560 570 580 590 600
ATLDCLSGDY NVEEGHGKER NEFLRKHNIE TYLIKQPEES LLSLPEDIVK
610 620 630 640 650
ESVSCSDRRN SGATFTEGSW SPELPFDNIV GKQNTLAALT RNSINLLPNH
660 670 680 690 700
LAQALHVQSG PEEINKRIEH TIDLRSGDKL RREHIKPFSL MFKDSSLEHK
710 720 730 740 750
YSQMRDEVFK SNLVCAFIVL LFITAIQSLL PSSRLMPMTI QFSILIMLHS
760 770 780 790 800
ALVLITTAED YKCLPLILRK TCCWINETYL ARNVIIFASI LINFLGAVIN
810 820 830 840 850
ILWCDFDKSI PLKNLTFNSS AVFTDICSYP EYFVFTGVLA MVTCAVFLRL
860 870 880 890 900
NSVLKLAVLL IMIAIYALLT ETIYAGLFLS YDNLNHSGED FLGTKEASLL
910 920 930 940 950
LMAMFLLAVF YHGQQLEYTA RLDFLWRVQA KEEINEMKDL REHNENMLRN
960 970 980 990 1000
ILPGHVARHF LEKDRDNEEL YSQSYDAVGV MFASIPGFAD FYSQTEMNNQ
1010 1020 1030 1040 1050
GVECLRLLNE IIADFDELLG EDRFQDIEKI KTIGSTYMAV SGLSPEKQQC
1060 1070 1080 1090 1100
EDKWGHLCAL ADFSLALTES IQEINKHSFN NFELRIGISH GSVVAGVIGA
1110 1120 1130 1140 1150
KKPQYDIWGK TVNLASRMDS TGVSGRIQVP EETYLILKDQ GFAFDYRGEI
1160 1170 1180 1190 1200
YVKGISEQEG KIKTYFLLGR VQPNPFILPP RRLPGQYSLA AVVLGLVQSL
1210 1220 1230 1240
NRQRQKQLLN ENSNSGIIKS HYNRRTLLTP SGPEPGAQAE GTDKSDLP
Length:1,248
Mass (Da):139,809
Last modified:November 16, 2011 - v1
Checksum:iE050BBF609648E9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06051492 Genomic DNA. No translation available.
AABR06051493 Genomic DNA. No translation available.
AABR06051494 Genomic DNA. No translation available.
AABR06051495 Genomic DNA. No translation available.
AABR06051496 Genomic DNA. No translation available.
AABR06051497 Genomic DNA. No translation available.
AABR06051498 Genomic DNA. No translation available.
AABR06051499 Genomic DNA. No translation available.
CH473950 Genomic DNA. Translation: EDM16168.1.
UniGeneiRn.10382.

Genome annotation databases

EnsembliENSRNOT00000006789; ENSRNOP00000006789; ENSRNOG00000004890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06051492 Genomic DNA. No translation available.
AABR06051493 Genomic DNA. No translation available.
AABR06051494 Genomic DNA. No translation available.
AABR06051495 Genomic DNA. No translation available.
AABR06051496 Genomic DNA. No translation available.
AABR06051497 Genomic DNA. No translation available.
AABR06051498 Genomic DNA. No translation available.
AABR06051499 Genomic DNA. No translation available.
CH473950 Genomic DNA. Translation: EDM16168.1 .
UniGenei Rn.10382.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006789 ; ENSRNOP00000006789 ; ENSRNOG00000004890 .

Organism-specific databases

RGDi 2036. Adcy8.

Phylogenomic databases

GeneTreei ENSGT00760000119042.
OMAi DVRCLSG.
OrthoDBi EOG7B8S30.
TreeFami TF313845.

Enzyme and pathway databases

Reactomei REACT_196394. CREB phosphorylation through the activation of Adenylate Cyclase.

Miscellaneous databases

NextBioi 35583762.
PROi G3V6N0.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
IPR029787. Nucleotide_cyclase.
[Graphical view ]
Pfami PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiG3V6N0_RAT
AccessioniPrimary (citable) accession number: G3V6N0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 29, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3