Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Diacylglycerol kinase

Gene

DGKA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi42 – 53PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi87 – 98PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, CalciumPROSITE-ProRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinaseUniRule annotation (EC:2.7.1.107UniRule annotation)
Short name:
DAG kinaseUniRule annotation
Gene namesi
Name:DGKAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:2849. DGKA.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000065357.

PTM / Processingi

Proteomic databases

MaxQBiG3V4E1.
PaxDbiG3V4E1.
PeptideAtlasiG3V4E1.
PRIDEiG3V4E1.

Expressioni

Gene expression databases

BgeeiENSG00000065357.
ExpressionAtlasiG3V4E1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliG3V4E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 64EF-handInterPro annotationAdd BLAST36
Domaini74 – 109EF-handInterPro annotationAdd BLAST36
Domaini124 – 172Phorbol-ester/DAG-typeInterPro annotationAdd BLAST49
Domaini188 – 238Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51
Domaini291 – 425DAGKcInterPro annotationAdd BLAST135

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1169. Eukaryota.
ENOG410XQVB. LUCA.
GeneTreeiENSGT00760000119050.

Family and domain databases

CDDicd00029. C1. 1 hit.
cd00051. EFh. 1 hit.
Gene3Di3.40.50.10330. 1 hit.
InterProiView protein in InterPro
IPR017438. ATP-NAD_kinase_dom_1.
IPR029477. DAG_kinase_typeI_N.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR016064. NAD/diacylglycerol_kinase.
IPR002219. PE/DAG-bd.
PfamiView protein in Pfam
PF00130. C1_1. 2 hits.
PF14513. DAG_kinase_N. 1 hit.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
SMARTiView protein in SMART
SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00054. EFh. 2 hits.
SUPFAMiSSF111331. SSF111331. 1 hit.
SSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS50146. DAGK. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 2 hits.

Sequencei

Sequence statusi: Fragment.

G3V4E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKERGLISP SDFAQLQKYM EYSTKKGGRP EDKLEFTFKL YDTDRNGILD
60 70 80 90 100
SSEVDKIILQ MMRVAEYLDW DVSELRPILQ EMMKEIDYDG SGSVSQAEWV
110 120 130 140 150
RAGATTVPLL VLLGLEMTLK DDGQHMWRPK RFPRPVYCNL CESSIGLGKQ
160 170 180 190 200
GLSCNLCKYT VHDQCAMKAL PCEVSTYAKS RKDIGVQSHV WVRGGCESGR
210 220 230 240 250
CDRCQKKIRI YHSLTGLHCV WCHLEIHDDC LQAVGHECDC GLLRDHILPP
260 270 280 290 300
SSIYPSVLAS GPDRKNSKTS QKTMDDLNLS TSEALRIDPV PNTHPLLVFV
310 320 330 340 350
NPKSGGKQGQ RVLWKFQYIL NPRQVFNLLK DGPEIGLRLF KDVPDSRILV
360 370 380 390 400
CGGDGTVGWI LETIDKANLP VLPPVAVLPL GTGNDLARCL RWGGGYEGQN
410 420 430 440 450
LAKILKDLEM SKVVHMDRWS VEVIPQQTEE KSDPVPFQII NNYFSIGVDA
460 470 480 490 500
SIAHRFHIMR EKYPEKFNSR MKNKLWYFEF ATSESIFSTC KKLEESLTVE
510 520 530 540
ICGKPLDLSN LSLEGIAVLN IPSMHGGSNL WGDTRRPHGD IYGIN
Length:545
Mass (Da):61,407
Last modified:November 16, 2011 - v1
Checksum:iC1438A3E88EDA385
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei545Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025162 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000555218; ENSP00000451743; ENSG00000065357.
UCSCiuc058pcu.1. human.

Similar proteinsi

Entry informationi

Entry nameiG3V4E1_HUMAN
AccessioniPrimary (citable) accession number: G3V4E1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: July 5, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported