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G3V3P9

- G3V3P9_HUMAN

UniProt

G3V3P9 - G3V3P9_HUMAN

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Protein
Submitted name:

Homeobox protein OTX2

Gene

OTX2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. cell fate specification Source: Ensembl
  2. diencephalon morphogenesis Source: Ensembl
  3. dorsal/ventral pattern formation Source: Ensembl
  4. endoderm development Source: Ensembl
  5. eye photoreceptor cell fate commitment Source: Ensembl
  6. inner ear morphogenesis Source: Ensembl
  7. metencephalon development Source: Ensembl
  8. midbrain development Source: Ensembl
  9. neuron fate determination Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. primitive streak formation Source: Ensembl
  12. somite rostral/caudal axis specification Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox protein OTX2Imported
Gene namesi
Name:OTX2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:8522. OTX2.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiG3V3P9.
ExpressionAtlasiG3V3P9. baseline and differential.

Family & Domainsi

Keywords - Domaini

HomeoboxUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118908.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003022. Otx2_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01257. OTX2HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

G3V3P9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPGPWASCPA ATPRKQRRER
60 70 80 90 100
TTFTRAQLDV LEALFAKTRY PDIFMREEVA LKINLPESRV QVWFKNRRAK
110 120 130 140 150
CRQQQQQQQN GGQNKVRPAK KKTSPAREVS SESGTSGQFT PPSSTSVPTI
160 170 180 190 200
ASSSAPVSIW SPASISPLSD PLSTSSSCMQ RSYPMTYTQA SGYSQGYAGS
210 220 230
TSYFGGMDCG SYLTPMHHQL PGPGATLSPM GTNAVTSHL
Length:239
Mass (Da):25,976
Last modified:October 29, 2014 - v3
Checksum:iC4924C085C9D7761
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei239 – 2391Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161757 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000554845; ENSP00000451357; ENSG00000165588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL161757 Genomic DNA. No translation available.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000554845 ; ENSP00000451357 ; ENSG00000165588 .

Organism-specific databases

HGNCi HGNC:8522. OTX2.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118908.

Miscellaneous databases

NextBioi 35517164.

Gene expression databases

Bgeei G3V3P9.
ExpressionAtlasi G3V3P9. baseline and differential.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003022. Otx2_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view ]
PRINTSi PR01257. OTX2HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiG3V3P9_HUMAN
AccessioniPrimary (citable) accession number: G3V3P9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: October 29, 2014
Last modified: November 26, 2014
This is version 24 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3