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Protein
Submitted name:

Nardilysin

Gene

NRDC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM16.987.

Names & Taxonomyi

Protein namesi
Submitted name:
NardilysinImported
Submitted name:
Nardilysin (N-arginine dibasic convertase), isoform CRA_eImported
Gene namesi
Name:NRDCImported
Synonyms:NRD1Imported
ORF Names:hCG_40292Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7995. NRDC.

PTM / Processingi

Proteomic databases

PeptideAtlasiG3V1R5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000346890.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 272128Peptidase_M16InterPro annotationAdd
BLAST
Domaini299 – 483185Peptidase_M16_CInterPro annotationAdd
BLAST
Domaini489 – 770282Peptidase_M16_MInterPro annotationAdd
BLAST
Domaini775 – 956182Peptidase_M16_CInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili47 – 8135Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M16 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0959. Eukaryota.
COG1025. LUCA.
GeneTreeiENSGT00530000063327.

Family and domain databases

Gene3Di3.30.830.10. 4 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
IPR032632. Peptidase_M16_M.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 2 hits.
PF16187. Peptidase_M16_M. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 4 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3V1R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGKTGNTTD DEEEEEVEEE EEDDDEDSGA EIEDDDEEGF DDEDEFDDEH
60 70 80 90 100
DDDLDTEDNE LEELEERAEA RKKTTEKQQL QSLFLLWSKL TDRLWFKSTY
110 120 130 140 150
SKMSSTLLVE TRNLYGVVGA ESRSAPVQHL AGWQAEEQQG ETDTVLSAAA
160 170 180 190 200
LCVGVGSFAD PDDLPGLAHF LEHMVFMGSL KYPDENGFDA FLKKHGGSDN
210 220 230 240 250
ASTDCERTVF QFDVQRKYFK EALDRWAQFF IHPLMIRDAI DREVEAVDSE
260 270 280 290 300
YQLARPSDAN RKEMLFGSLA RPGHPMGKFF WGNAETLKHE PRKNNIDTHA
310 320 330 340 350
RLREFWMRYY SSHYMTLVVQ SKETLDTLEK WVTEIFSQIP NNGLPRPNFG
360 370 380 390 400
HLTDPFDTPA FNKLYRVVPI RKIHALTITW ALPPQQQHYR VKPLHYISWL
410 420 430 440 450
VGHEGKGSIL SFLRKKCWAL ALFGGNGETG FEQNSTYSVF SISITLTDEG
460 470 480 490 500
YEHFYEVAYT VFQYLKMLQK LGPEKRIFEE IRKIEDNEFH YQEQTDPVEY
510 520 530 540 550
VENMCENMQL YPLQDILTGD QLLFEYKPEV IGEALNQLVP QKANLVLLSG
560 570 580 590 600
ANEGKCDLKE KWFGTQYSIE DIENSWAELW NSNFELNPDL HLPAENKYIA
610 620 630 640 650
TDFTLKAFDC PETEYPVKIV NTPQGCLWYK KDNKFKIPKA YIRFHLISPL
660 670 680 690 700
IQKSAANVVL FDIFVNILTH NLAEPAYEAD VAQLEYKLVA GEHGLIIRVK
710 720 730 740 750
GFNHKLPLLF QLIIDYLAEF NSTPAVFTMI TEQLKKTYFN ILIKPETLAK
760 770 780 790 800
DVRLLILEYA RWSMIDKYQA LMDGLSLESL LSFVKEFKSQ LFVEGLVQGN
810 820 830 840 850
VTSTESMDFL KYVVDKLNFK PLEQEMPVQF QVVELPSGHH LCKVKALNKG
860 870 880 890 900
DANSEVTVYY QSGTRSLREY TLMELLVMHM EEPCFDFLRT KQTLGYHVYP
910 920 930 940 950
TCRNTSGILG FSVTVGTQAT KYNSEVVDKK IEEFLSSFEE KIENLTEEAF
960 970 980 990 1000
NTQVTALIKL KECEDTHLGE EVDRNWNEVV TQQYLFDRLA HEIEALKSFS
1010 1020 1030 1040 1050
KSDLVNWFKA HRGPGSKMLS VHVVGYGKYE LEEDGTPSSE DSNSSCEVMQ
1060 1070 1080
LTYLPTSPLL ADCIIPITDI RAFTTTLNLL PYHKIVK
Length:1,087
Mass (Da):125,119
Last modified:November 16, 2011 - v1
Checksum:i7E675CC85574DC2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050343 Genomic DNA. No translation available.
AL589663 Genomic DNA. No translation available.
KF495940 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06808.1.
RefSeqiNP_001229290.1. NM_001242361.1.
UniGeneiHs.584782.

Genome annotation databases

EnsembliENST00000539524; ENSP00000444416; ENSG00000078618.
GeneIDi4898.
UCSCiuc001cte.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050343 Genomic DNA. No translation available.
AL589663 Genomic DNA. No translation available.
KF495940 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06808.1.
RefSeqiNP_001229290.1. NM_001242361.1.
UniGeneiHs.584782.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000346890.

Protein family/group databases

MEROPSiM16.987.

Proteomic databases

PeptideAtlasiG3V1R5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000539524; ENSP00000444416; ENSG00000078618.
GeneIDi4898.
UCSCiuc001cte.4. human.

Organism-specific databases

CTDi4898.
HGNCiHGNC:7995. NRDC.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0959. Eukaryota.
COG1025. LUCA.
GeneTreeiENSGT00530000063327.

Miscellaneous databases

ChiTaRSiNRD1. human.
GenomeRNAii4898.

Family and domain databases

Gene3Di3.30.830.10. 4 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
IPR032632. Peptidase_M16_M.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 2 hits.
PF16187. Peptidase_M16_M. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 4 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., Porter K.M., Prigmore E.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiG3V1R5_HUMAN
AccessioniPrimary (citable) accession number: G3V1R5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: July 6, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.