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Protein
Submitted name:

Exosome complex exonuclease RRP44

Gene

DIS3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Exosome complex exonuclease RRP44Imported
Submitted name:
KIAA1008, isoform CRA_cImported
Gene namesi
Name:DIS3Imported
Synonyms:KIAA1008Imported
ORF Names:hCG_32200Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:20604. DIS3.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000083520.

Expressioni

Gene expression databases

BgeeiENSG00000083520.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 157Rrp44_CSD1InterPro annotationAdd BLAST93
Domaini685 – 756Rrp44_S1InterPro annotationAdd BLAST72

Phylogenomic databases

eggNOGiKOG2102. Eukaryota.
COG0557. LUCA.
GeneTreeiENSGT00530000063106.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR029060. PIN_domain-like.
IPR022966. RNase_II/R_CS.
IPR033771. Rrp44_CSD1.
IPR033770. RRP44_S1.
PfamiView protein in Pfam
PF17216. Rrp44_CSD1. 1 hit.
PF17215. Rrp44_S1. 1 hit.
SUPFAMiSSF50249. SSF50249. 4 hits.
PROSITEiView protein in PROSITE
PS01175. RIBONUCLEASE_II. 1 hit.

Sequencei

Sequence statusi: Complete.

G3V1J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADNQLQVI FITNDRRNKE KAIEEGIPAF TCEEYVKSLT ANPELIDRLA
60 70 80 90 100
CLSEEGNEIE SGKIIFSEHL PLSKLQQGIK SGTYLQGTFR ASRENYLEAT
110 120 130 140 150
VWIHGDNEEN KEIILQGLKH LNRAVHEDIV AVELLPKSQW VAPSSVVLHD
160 170 180 190 200
EGQNEEDVEK EEETERMLKT AVSEKMLKPT GRVVGIIKRN WRPYCGMLSK
210 220 230 240 250
SDIKESRRHL FTPADKRIPR IRIETRQAST LEGRRIIVAI DGWPRNSRYP
260 270 280 290 300
NGHFVRNLGD VGEKETETEV LLLEHDVPHQ PFSQAVLSFL PKMPWSITEK
310 320 330 340 350
DMKNREDLRH LCICSVDPPG CTDIDDALHC RELENGNLEV GVHIADVSHF
360 370 380 390 400
IRPGNALDQE SARRGTTVYL CEKRIDMVPE LLSSNLCSLK CDVDRLAFSC
410 420 430 440 450
IWEMNHNAEI LKTKFTKSVI NSKASLTYAE AQLRIDSANM NDDITTSLRG
460 470 480 490 500
LNKLAKILKK RRIEKGALTL SSPEVRFHMD SETHDPIDLQ TKELRETNSM
510 520 530 540 550
VEEFMLLANI SVAKKIHEEF SEHALLRKHP APPPSNYEIL VKAARSRNLE
560 570 580 590 600
IKTDTAKSLA ESLDQAESPT FPYLNTLLRI LATRCMMQAV YFCSGMDNDF
610 620 630 640 650
HHYGLASPIY THFTSPIRRY ADVIVHRLLA VAIGADCTYP ELTDKHKLAD
660 670 680 690 700
ICKNLNFRHK MAQYAQRASV AFHTQLFFKS KGIVSEEAYI LFVRKNAIVV
710 720 730 740 750
LIPKYGLEGT VFFEEKDKPN PQLIYDDEIP SLKIEDTVFH VFDKVKVKIM
760 770 780 790
LDSSNLQHQK IRMSLVEPQI PGISIPTDTS NMDLNGPKKK KMKLGK
Length:796
Mass (Da):90,584
Last modified:November 16, 2011 - v1
Checksum:i4DFB954BBFFD6EE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138695 Genomic DNA. No translation available.
AL391384 Genomic DNA. No translation available.
CH471093 Genomic DNA. Translation: EAW80519.1.
RefSeqiNP_001309278.1. NM_001322349.1.
UniGeneiHs.744104.

Genome annotation databases

EnsembliENST00000545453; ENSP00000440058; ENSG00000083520.
GeneIDi22894.
UCSCiuc058xku.1. human.

Similar proteinsi

Entry informationi

Entry nameiG3V1J5_HUMAN
AccessioniPrimary (citable) accession number: G3V1J5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: August 30, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported