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Protein

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

Gene

B3GAT3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferaseUniRule annotation (EC:2.4.1.135UniRule annotation)
Gene namesi
Name:B3GAT3Imported
ORF Names:hCG_16017Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149541.9.
HGNCiHGNC:923. B3GAT3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatusUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149541.

PTM / Processingi

Proteomic databases

MaxQBiG3V150.

Expressioni

Gene expression databases

BgeeiENSG00000149541.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 43 family.UniRule annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane

Phylogenomic databases

eggNOGiKOG1476. Eukaryota.
ENOG410XP79. LUCA.
GeneTreeiENSGT00390000017640.

Family and domain databases

CDDicd00218. GlcAT-I. 1 hit.
Gene3Di3.90.550.10. 1 hit.
InterProiView protein in InterPro
IPR005027. Glyco_trans_43.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR10896. PTHR10896. 1 hit.
PfamiView protein in Pfam
PF03360. Glyco_transf_43. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

G3V150-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKLKNVFL AYFLVSIAGL LYALVQLGQP CDCLPPLRAA AEQLRQKDLR
60 70 80 90 100
ISQLQAELRR PPPAPAQPPE PEALPTIYVV TPTYARLVQK AELVRLSQTL
110 120 130 140 150
SLVPRLHWLL VEDAEGPTPL VSGLLAASGL LFTHLVVLTP KAQRLREGEP
160 170 180 190 200
GWVHPRGVEQ RNKALDWLRG RGGAVGGEKD PPPPGTQGVV YFADDDNTYS
210 220 230 240 250
RELFEEMRWT RGVSVWPVGL VGGLRFEGPQ VQDGRVVGFH TAWEPSRPFP
260 270 280 290 300
VDMAGFAVAL PLLLDKPNAQ FDSTAPRGHL ESSLLSHLVD PKDLEPRAAN
310
CTRSLAVSPR LECSSAILA
Length:319
Mass (Da):34,963
Last modified:November 16, 2011 - v1
Checksum:i1BD9BE4486ABEDAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001458 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74042.1.
RefSeqiNP_001275651.1. NM_001288722.1.
UniGeneiHs.502759.

Genome annotation databases

EnsembliENST00000531383; ENSP00000431359; ENSG00000149541.
GeneIDi26229.
UCSCiuc058cjk.1. human.

Similar proteinsi

Entry informationi

Entry nameiG3V150_HUMAN
AccessioniPrimary (citable) accession number: G3V150
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 22, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported