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Protein
Submitted name:

Transferrin receptor (P90, CD71), isoform CRA_c

Gene

TFRC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Transferrin receptor (P90, CD71), isoform CRA_cImported
Submitted name:
Transferrin receptor protein 1Imported
Gene namesi
Name:TFRCImported
ORF Names:hCG_22086Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000072274.12.
HGNCiHGNC:11763. TFRC.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000072274.

PTM / Processingi

Proteomic databases

MaxQBiG3V0E5.

Expressioni

Gene expression databases

BgeeiENSG00000072274.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 264PAInterPro annotationAdd BLAST118
Domaini307 – 495Peptidase_M28InterPro annotationAdd BLAST189
Domaini556 – 668TFR_dimerInterPro annotationAdd BLAST113

Phylogenomic databases

eggNOGiKOG2195. Eukaryota.
COG2234. LUCA.
GeneTreeiENSGT00550000074421.

Family and domain databases

Gene3Di1.20.930.40. 1 hit.
InterProiView protein in InterPro
IPR003137. PA_domain.
IPR007484. Peptidase_M28.
IPR029513. TfR.
IPR007365. TFR-like_dimer_dom.
PANTHERiPTHR10404:SF54. PTHR10404:SF54. 1 hit.
PfamiView protein in Pfam
PF02225. PA. 1 hit.
PF04389. Peptidase_M28. 1 hit.
PF04253. TFR_dimer. 1 hit.
SUPFAMiSSF47672. SSF47672. 1 hit.

Sequencei

Sequence statusi: Complete.

G3V0E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGYLGYCKG VEPKTECERL AGTESPVREE PGEDFPAARR LYWDDLKRKL
60 70 80 90 100
SEKLDSTDFT GTIKLLNENS YVPREAGSQK DENLALYVEN QFREFKLSKV
110 120 130 140 150
WRDQHFVKIQ VKDSAQNSVI IVDKNGRLVY LVENPGGYVA YSKAATVTGK
160 170 180 190 200
LVHANFGTKK DFEDLYTPVN GSIVIVRAGK ITFAEKVANA ESLNAIGVLI
210 220 230 240 250
YMDQTKFPIV NAELSFFGHA HLGTGDPYTP GFPSFNHTQF PPSRSSGLPN
260 270 280 290 300
IPVQTISRAA AEKLFGNMEG DCPSDWKTDS TCRMVTSESK NVKLTVSNVL
310 320 330 340 350
KEIKILNIFG VIKGFVEPDH YVVVGAQRDA WGPGAAKSGV GTALLLKLAQ
360 370 380 390 400
MFSDMVLKDG FQPSRSIIFA SWSAGDFGSV GATEWLEGYL SSLHLKAFTY
410 420 430 440 450
INLDKAVLGT SNFKVSASPL LYTLIEKTMQ NVKHPVTGQF LYQDSNWASK
460 470 480 490 500
VEKLTLDNAA FPFLAYSGIP AVSFCFCEDT DYPYLGTTMD TYKELIERIP
510 520 530 540 550
ELNKVARAAA EVAGQFVIKL THDVELNLDY ERYNSQLLSF VRDLNQYRAD
560 570 580 590 600
IKEMGLSLQW LYSARGDFFR ATSRLTTDFG NAEKTDRFVM KKLNDRVMRV
610 620 630 640 650
EYHFLSPYVS PKESPFRHVF WGSGSHTLPA LLENLKLRKQ NNGAFNETLF
660 670
RNQLALATWT IQGAANALSG DVWDIDNEF
Length:679
Mass (Da):75,964
Last modified:November 16, 2011 - v1
Checksum:i00830FDA9668C11B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024937 Genomic DNA. No translation available.
CH471191 Genomic DNA. Translation: EAW53672.1.
RefSeqiNP_001300894.1. NM_001313965.1.
UniGeneiHs.529618.

Genome annotation databases

EnsembliENST00000420415; ENSP00000390133; ENSG00000072274.
GeneIDi7037.
UCSCiuc010hzy.4. human.

Similar proteinsi

Entry informationi

Entry nameiG3V0E5_HUMAN
AccessioniPrimary (citable) accession number: G3V0E5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 27, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported