ID   G3UZL5_MOUSE            Unreviewed;       668 AA.
AC   G3UZL5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 2.
DT   27-MAR-2024, entry version 83.
DE   SubName: Full=Discs large MAGUK scaffold protein 4 {ECO:0000313|Ensembl:ENSMUSP00000134545.3};
GN   Name=Dlg4 {ECO:0000313|Ensembl:ENSMUSP00000134545.3,
GN   ECO:0000313|MGI:MGI:1277959};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000134545.3, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0007829|PubMed:16452087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
RA   Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT   "Comprehensive identification of phosphorylation sites in postsynaptic
RT   density preparations.";
RL   Mol. Cell. Proteomics 5:914-922(2006).
RN   [2] {ECO:0007829|PubMed:18034455}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18034455; DOI=10.1021/pr0701254;
RA   Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
RT   "Large-scale identification and evolution indexing of tyrosine
RT   phosphorylation sites from murine brain.";
RL   J. Proteome Res. 7:311-318(2008).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000134545.3, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134545.3,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [5] {ECO:0000313|Ensembl:ENSMUSP00000134545.3}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134545.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; G3UZL5; -.
DR   SMR; G3UZL5; -.
DR   jPOST; G3UZL5; -.
DR   PeptideAtlas; G3UZL5; -.
DR   ProteomicsDB; 370103; -.
DR   Antibodypedia; 1930; 1049 antibodies from 50 providers.
DR   Ensembl; ENSMUST00000123687.3; ENSMUSP00000134545.3; ENSMUSG00000020886.18.
DR   AGR; MGI:1277959; -.
DR   MGI; MGI:1277959; Dlg4.
DR   VEuPathDB; HostDB:ENSMUSG00000020886; -.
DR   GeneTree; ENSGT00940000157956; -.
DR   HOGENOM; CLU_001715_4_1_1; -.
DR   ChiTaRS; Dlg4; mouse.
DR   Proteomes; UP000000589; Chromosome 11.
DR   Bgee; ENSMUSG00000020886; Expressed in retinal neural layer and 176 other cell types or tissues.
DR   ExpressionAtlas; G3UZL5; baseline and differential.
DR   GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:UniProt.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR   GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR   GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   CDD; cd12030; SH3_DLG4; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR   InterPro; IPR016313; DLG1-like.
DR   InterPro; IPR019590; DLG1_PEST_dom.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF33; DISKS LARGE HOMOLOG 4; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF10608; MAGUK_N_PEST; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF10600; PDZ_assoc; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PIRSF; PIRSF001741; MAGUK_DLGH; 3.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM01277; MAGUK_N_PEST; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
DR   PROSITE; PS50002; SH3; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:G3UZL5,
KW   ECO:0007829|MaxQB:G3UZL5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..668
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016346070"
FT   DOMAIN          108..195
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          203..290
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          356..437
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          471..541
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          577..668
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
FT   REGION          58..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   668 AA;  74012 MW;  1192E0F45BCF5B23 CRC64;
     MSQRPRAPRS ALWLLAPPLL RWAPPLLTVL HSDLFQALLD ILDYYEACIS ESQKYRYQDE
     DTPPLEHSPA HLPNQANSPP VIVNTDTLEA PGYELQVNGT EGEMEYEEIT LERGNSGLGF
     SIAGGTDNPH IGDDPSIFIT KIIPGGAAAQ DGRLRVNDSI LFVNEVDVRE VTHSAAVEAL
     KEAGSIVRLY VMRRKPPAEK IIEIKLIKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIEG
     GAAHKDGRLQ IGDKILAVNS VGLEDVMHED AVAALKNTYD VVYLKVAKPS NAYLSDSYAP
     PDITTSYSQH LDNEISHSSY LGTDYPTAMT PTSPRRYSPV AKDLLGEEDI PREPRRIVIH
     RGSTGLGFNI VGGEDGEGIF ISFILAGGPA DLSGELRKGD QILSVNGVDL RNASHEQAAI
     ALKNAGQTVT IIAQYKPEEY SRFEAKIHDL REQLMNSSLG SGTASLRSNP KRGFYIRALF
     DYDKTKDCGF LSQALSFHFG DVLHVIDASD EEWWQARRVH SDSETDDIGF IPSKRRVERR
     EWSRLKAKDW GSSSGSQGRE DSVLSYETVT QMEVHYARPI IILGPTKDRA NDDLLSEFPD
     KFGSCVPHTT RPKREYEIDG RDYHFVSSRE KMEKDIQAHK FIEAGQYNSH LYGTSVQSVR
     EVAEQRDQ
//