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Protein
Submitted name:

Serine/threonine-protein kinase LATS2

Gene

Lats2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: MGI
  2. protein serine/threonine kinase activity Source: MGI

GO - Biological processi

  1. cellular protein localization Source: MGI
  2. G1/S transition of mitotic cell cycle Source: MGI
  3. hippo signaling Source: MGI
  4. hormone-mediated signaling pathway Source: MGI
  5. intracellular signal transduction Source: MGI
  6. keratinocyte differentiation Source: MGI
  7. mitotic nuclear division Source: InterPro
  8. negative regulation of canonical Wnt signaling pathway Source: MGI
  9. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
  10. protein phosphorylation Source: MGI
  11. regulation of organ growth Source: MGI
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase LATS2Imported
Gene namesi
Name:Lats2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1354386. Lats2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. microtubule organizing center Source: MGI
  3. nucleus Source: MGI
  4. spindle pole Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiG3UYM3.
ExpressionAtlasiG3UYM3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliG3UYM3.
SMRiG3UYM3. Positions 227-270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118994.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR028742. LATS2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PANTHERiPTHR24356:SF149. PTHR24356:SF149. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

G3UYM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PSRTNSFNNP QPEPSLPAPN TVTAVTAAHI LHPVKSVRVL RPEPQTAVGP
60 70 80 90 100
SHPAWVAAPT APATESLETK EGSAGPHPLD VDYGGSERRC PPPPYPKHLL
110 120 130 140 150
LPSKSEQYSV DLDSLCTSVQ QSLRGGTEQD RSDKSHKGAK GDKAGRDKKQ
160 170 180 190 200
IQTSPVPVRK NSRDEEKRES RIKSYSPYAF KFFMEQHVEN VIKTYQQKAG
210 220 230 240 250
LCEAEQEQMR KILYQKESNY NRLKRAKMDK SMFVKIKTLG IGAFGEVCLA
260 270 280
CKLDTHALYA MKTLRKKDVL NRNQVAHVKA ERDILAEA
Length:288
Mass (Da):32,095
Last modified:November 16, 2011 - v1
Checksum:i645C096917CF7E74
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei288 – 2881Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154504 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000173964; ENSMUSP00000134142; ENSMUSG00000021959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154504 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliG3UYM3.
SMRiG3UYM3. Positions 227-270.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000173964; ENSMUSP00000134142; ENSMUSG00000021959.

Organism-specific databases

MGIiMGI:1354386. Lats2.

Phylogenomic databases

GeneTreeiENSGT00760000118994.

Miscellaneous databases

ChiTaRSiLats2. mouse.
NextBioi35560650.
SOURCEiSearch...

Gene expression databases

BgeeiG3UYM3.
ExpressionAtlasiG3UYM3. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR028742. LATS2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PANTHERiPTHR24356:SF149. PTHR24356:SF149. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiG3UYM3_MOUSE
AccessioniPrimary (citable) accession number: G3UYM3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 4, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.