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Protein
Submitted name:

Potassium voltage-gated channel subfamily KQT member 5

Gene

Kcnq5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage-gated channel subfamily KQT member 5Imported
Gene namesi
Name:Kcnq5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1924937. Kcnq5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei128 – 150HelicalSequence analysisAdd BLAST23
Transmembranei156 – 181HelicalSequence analysisAdd BLAST26
Transmembranei202 – 220HelicalSequence analysisAdd BLAST19
Transmembranei270 – 288HelicalSequence analysisAdd BLAST19
Transmembranei327 – 353HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiG3UYG5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028033.
ExpressionAtlasiG3UYG5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliG3UYG5.
SMRiG3UYG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 353Ion_transInterPro annotationAdd BLAST223
Domaini439 – 626KCNQ_channelInterPro annotationAdd BLAST188

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1419. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00550000074513.

Family and domain databases

InterProiView protein in InterPro
IPR005821. Ion_trans_dom.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR028325. VG_K_chnl.
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiView protein in Pfam
PF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
PRINTSiPR00169. KCHANNEL.
PR01459. KCNQCHANNEL.

Sequencei

Sequence statusi: Complete.

G3UYG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRHHAGGEE GGAAGLWVRS GAAAAAGAGG GRPGSGMKDV ESGRGRVLLN
60 70 80 90 100
SAAARGDGLL LLGTRAAALG GGGGGLRESR RGKQGARMSL LGKPLSYTSS
110 120 130 140 150
QSCRRNVKYR RVQNYLYNVL ERPRGWAFVY HAFVFLLVFG CLILSVFSTI
160 170 180 190 200
PEHTKLASSC LLILEFVMIV VFGLEFIIRI WSAGCCCRYR GWQGRLRFAR
210 220 230 240 250
KPFCVIDTIV LIASIAVVSA KTQGNIFATS ALRSLRFLQI LRMVRMDRRG
260 270 280 290 300
GTWKLLGSVV YAHSKELITA WYIGFLVLIF SSFLVYLVEK DANKEFSTYA
310 320 330 340 350
DALWWGTITL TTIGYGDKTP LTWLGRLLSA GFALLGISFF ALPAGILGSG
360 370 380 390 400
FALKVQEQHR QKHFEKRRNP AANLIQCVWR SYAADEKSVS IATWKPHLKA
410 420 430 440 450
LHTCSPTNQK LSFKERVRMA SPRGQSIKSR QASVGDRRSP STDITAEGSP
460 470 480 490 500
TKVQKSWSFN DRTRFRPSLR LKSSQPKPVI DADTALGIDD VYDEKGCQCD
510 520 530 540 550
VSVEDLTPPL KTVIRAIRIM KFHVAKRKFK ETLRPYDVKD VIEQYSAGHL
560 570 580 590 600
DMLCRIKSLQ TRVDQILGKG QMTSDKKSRE KITAEHETTD DPSMLARVVK
610 620 630 640 650
VEKQVQSIES KLDCLLDIYQ QVLRKGSASA LTLASFQIPP FECEQTSDYQ
660 670 680 690 700
SPVDSKDLSG SAQNSGCLTR SASANISRGL QFILTPNEFS AQTFYALSPT
710 720 730 740 750
MHSQATQVPM SQNDGSSVVA TNNIANQISA APKPAAPTTL QIPPPLSAIK
760 770 780 790 800
HLSRPEPLLS NPTGLQESIS DVTTCLVASK ESVQFAQSNL TKDRSLRKSF
810 820 830 840 850
DMGGETLLSV RPMVPKDLGK SLSVQNLIRS TEELNLQFSG SESSGSRGSQ
860 870 880 890 900
DFYPKWRESK LFITDEEVGA EETETDTFDG TPPPAGEAAF SSDSLRTGRS
910 920
RSSQNICKTG DSTDALSLPH VKLN
Length:924
Mass (Da):101,340
Last modified:November 16, 2011 - v1
Checksum:iC9B8A62E133C0790
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110269 Genomic DNA. No translation available.
AC115920 Genomic DNA. No translation available.
AC125483 Genomic DNA. No translation available.
AC131088 Genomic DNA. No translation available.
RefSeqiNP_001297406.1. NM_001310477.1.
UniGeneiMm.336519.
Mm.403737.

Genome annotation databases

EnsembliENSMUST00000173404; ENSMUSP00000134076; ENSMUSG00000028033.
GeneIDi226922.

Similar proteinsi

Entry informationi

Entry nameiG3UYG5_MOUSE
AccessioniPrimary (citable) accession number: G3UYG5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported