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G3UY78

- G3UY78_MOUSE

UniProt

G3UY78 - G3UY78_MOUSE

Protein
Submitted name:

Serine/threonine-protein kinase LATS2

Gene

Lats2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: InterPro

    GO - Biological processi

    1. cellular protein localization Source: MGI
    2. hippo signaling Source: MGI
    3. keratinocyte differentiation Source: MGI
    4. mitotic nuclear division Source: InterPro
    5. negative regulation of canonical Wnt signaling pathway Source: MGI
    6. protein phosphorylation Source: MGI
    7. regulation of organ growth Source: MGI

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Serine/threonine-protein kinase LATS2Imported
    Gene namesi
    Name:Lats2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1354386. Lats2.

    Expressioni

    Gene expression databases

    ArrayExpressiG3UY78.
    BgeeiG3UY78.

    Structurei

    3D structure databases

    ProteinModelPortaliG3UY78.
    SMRiG3UY78. Positions 91-138, 598-883.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00750000117422.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR028742. LATS2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    [Graphical view]
    PANTHERiPTHR24356:SF149. PTHR24356:SF149. 1 hit.
    PfamiPF00069. Pkinase. 2 hits.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3UY78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPKTFPATT YSGNSRQRLQ EIREGLKQPS KASTQGLLVG PNSDTSLDAK    50
    VLGSKDASRQ QQMRATPKFG PYQKALREIR YSLLPFANES GTSAAAEVNR 100
    QMLQELVNAG CDQEMAGRAL KQTGSRSIEA ALEYISKMGY LDPRNEQIVR 150
    VIKQTSPGKG LAPTPVTRRP SFEGTGEALP SYHQLGGANY EGPAALEEMP 200
    RQYLDFLFPG AGAGTHGAQA HQHPPKGYST AVEPSAHFPG THYGRGHLLS 250
    EQPGYGVQRS SSFQNKTPPD AYSSMAKAQG GPPASLTFPA HAGLYTASHH 300
    KPAATPPGAH PLHVLGTRGP TFTGESSAQA VLAPSRNSLN ADLYELGSTV 350
    PWSAAPLARR DSLQKQGLEA SRPHVAFRAG PSRTNSFNNP QPEPSLPAPN 400
    TVTAVTAAHI LHPVKSVRVL RPEPQTAVGP SHPAWVAAPT APATESLETK 450
    EGSAGPHPLD VDYGGSERRC PPPPYPKHLL LPSKSEQYSV DLDSLCTSVQ 500
    QSLRGGTEQD RSDKSHKGAK GDKAGRDKKQ IQTSPVPVRK NSRDEEKRES 550
    RIKSYSPYAF KFFMEQHVEN VIKTYQQKVS RRLQLEQEMA KAGLCEAEQE 600
    QMRKILYQKE SNYNRLKRAK MDKSMFVKIK TLGIGAFGEV CLACKLDTHA 650
    LYAMKTLRKK DVLNRNQVAH VKAERDILAE ADNEWVVKLY YSFQDKDSLY 700
    FVMDYIPGGD MMSLLIRMEV FPEHLARFYI AELTLAIESV HKMGFIHRDI 750
    KPDNILIDLD GHIKLTDFGL CTGFRWTHNS KYYQKGNHMR QDSMEPGDLW 800
    DDVSNCRCGD RLKTLEQRAQ KQHQRCLAHS LVGTPNYIAP EVLLRKGYTQ 850
    LCDWWSVGVI LFEMLVGQPP FLAPTPTETQ LKVSGTACQC VCVSR 895
    Length:895
    Mass (Da):98,926
    Last modified:November 16, 2011 - v1
    Checksum:iCFFAFDDAD76403F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC154504 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000173990; ENSMUSP00000133976; ENSMUSG00000021959.
    UCSCiuc007udl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC154504 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali G3UY78.
    SMRi G3UY78. Positions 91-138, 598-883.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000173990 ; ENSMUSP00000133976 ; ENSMUSG00000021959 .
    UCSCi uc007udl.1. mouse.

    Organism-specific databases

    MGIi MGI:1354386. Lats2.

    Phylogenomic databases

    GeneTreei ENSGT00750000117422.

    Miscellaneous databases

    ChiTaRSi LATS2. mouse.
    NextBioi 35560532.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi G3UY78.
    Bgeei G3UY78.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR028742. LATS2.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR009060. UBA-like.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    [Graphical view ]
    PANTHERi PTHR24356:SF149. PTHR24356:SF149. 1 hit.
    Pfami PF00069. Pkinase. 2 hits.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiG3UY78_MOUSE
    AccessioniPrimary (citable) accession number: G3UY78
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3