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G3UXG3

- G3UXG3_MOUSE

UniProt

G3UXG3 - G3UXG3_MOUSE

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Protein
Submitted name:

Serine/threonine-protein kinase LATS2

Gene

Lats2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular protein localization Source: MGI
  2. hippo signaling Source: MGI
  3. keratinocyte differentiation Source: MGI
  4. mitotic nuclear division Source: InterPro
  5. negative regulation of canonical Wnt signaling pathway Source: MGI
  6. protein phosphorylation Source: MGI
  7. regulation of organ growth Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/threonine-protein kinase LATS2Imported
Gene namesi
Name:Lats2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1354386. Lats2.

Expressioni

Gene expression databases

BgeeiG3UXG3.
ExpressionAtlasiG3UXG3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliG3UXG3.
SMRiG3UXG3. Positions 91-138, 585-849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118994.
OrthoDBiEOG7BZVS1.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR028742. LATS2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
[Graphical view]
PANTHERiPTHR24356:SF149. PTHR24356:SF149. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3UXG3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPKTFPATT YSGNSRQRLQ EIREGLKQPS KASTQGLLVG PNSDTSLDAK
60 70 80 90 100
VLGSKDASRQ QQMRATPKFG PYQKALREIR YSLLPFANES GTSAAAEVNR
110 120 130 140 150
QMLQELVNAG CDQEMAGRAL KQTGSRSIEA ALEYISKMGY LDPRNEQIVR
160 170 180 190 200
VIKQTSPGKG LAPTPVTRRP SFEGTGEALP SYHQLGGANY EGPAALEEMP
210 220 230 240 250
RQYLDFLFPG AGAGTHGAQA HQHPPKGYST AVEPSAHFPG THYGRGHLLS
260 270 280 290 300
EQPGYGVQRS SSFQNKTPPD AYSSMAKAQG GPPASLTFPA HAGLYTASHH
310 320 330 340 350
KPAATPPGAH PLHVLGTRGP TFTGESSAQA VLAPSRNSLN ADLYELGSTV
360 370 380 390 400
PWSAAPLARR DSLQKQGLEA SRPHVAFRAG PSRTNSFNNP QPEPSLPAPN
410 420 430 440 450
TVTAVTAAHI LHPVKSVRVL RPEPQTAVGP SHPAWVAAPT APATESLETK
460 470 480 490 500
EGSAGPHPLD VDYGGSERRC PPPPYPKHLL LPSKSEQYSV DLDSLCTSVQ
510 520 530 540 550
QSLRGGTEQD RSDKSHKGAK GDKAGRDKKQ IQTSPVPVRK NSRDEEKRES
560 570 580 590 600
RIKSYSPYAF KFFMEQHVEN VIKTYQQKVS RRLQLEQEMA KAGLCEAEQE
610 620 630 640 650
QMRKILYQKE SNYNRLKRAK MDKSMFVKIK TLGIGAFGEV CLACKLDTHA
660 670 680 690 700
LYAMKTLRKK DVLNRNQVAH VKAERDILAE ADNEWVVKLY YSFQDKDSLY
710 720 730 740 750
FVMDYIPGGD MMSLLIRMEV FPEHLARFYI AELTLAIESV HKMGFIHRDI
760 770 780 790 800
KPDNILIDLD GHIKLTDFGL CTGFRWTHNS KYYQKGNHMR QDSMEPGDLW
810 820 830 840 850
DDVSNCRCGD RLKTLEQRAQ KQHQRCLAHS LVGTPNYIAP EVLLRKGTTF

HGQ
Length:853
Mass (Da):94,312
Last modified:November 16, 2011 - v1
Checksum:i47E0494F61C52EDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC154504 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000174694; ENSMUSP00000133680; ENSMUSG00000021959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC154504 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali G3UXG3.
SMRi G3UXG3. Positions 91-138, 585-849.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000174694 ; ENSMUSP00000133680 ; ENSMUSG00000021959 .

Organism-specific databases

MGIi MGI:1354386. Lats2.

Phylogenomic databases

GeneTreei ENSGT00760000118994.
OrthoDBi EOG7BZVS1.

Miscellaneous databases

ChiTaRSi LATS2. mouse.
NextBioi 35560318.
SOURCEi Search...

Gene expression databases

Bgeei G3UXG3.
ExpressionAtlasi G3UXG3. baseline and differential.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR028742. LATS2.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
[Graphical view ]
PANTHERi PTHR24356:SF149. PTHR24356:SF149. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiG3UXG3_MOUSE
AccessioniPrimary (citable) accession number: G3UXG3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 29, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3