Tiam1

Functionⁱ

GO - Molecular functionⁱ

microtubule binding Source: Ensembl
Rac GTPase binding Source: Ensembl
Rac guanyl-nucleotide exchange factor activity Source: Ensembl
receptor tyrosine kinase binding Source: Ensembl
signal transducer activity, downstream of receptor Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

activation of GTPase activity Source: Ensembl
apoptotic process Source: Ensembl
cardiac muscle hypertrophy Source: Ensembl
cell-matrix adhesion Source: Ensembl
cell migration Source: Ensembl
neuron projection extension Source: Ensembl
NMDA selective glutamate receptor signaling pathway Source: Ensembl
positive regulation of axonogenesis Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of dendritic spine morphogenesis Source: Ensembl
positive regulation of JUN kinase activity Source: Ensembl
positive regulation of protein binding Source: Ensembl
positive regulation of Schwann cell chemotaxis Source: Ensembl
protein localization to membrane Source: Ensembl
Rac protein signal transduction Source: Ensembl
regulation of epithelial to mesenchymal transition Source: Ensembl
regulation of ERK1 and ERK2 cascade Source: Ensembl
regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
regulation of modification of postsynaptic actin cytoskeleton Source: Ensembl
regulation of Rho protein signal transduction Source: InterPro
response to cocaine Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factorSAAS annotation

Molecular function

Guanine-nucleotide releasing factorSAAS annotation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-193648. NRAGE signals death through JNK. R-MMU-194840. Rho GTPase cycle. R-MMU-3928662. EPHB-mediated forward signaling. R-MMU-3928665. EPH-ephrin mediated repulsion of cells. R-MMU-416482. G alpha (12/13) signalling events.

Reactomeⁱ

R-MMU-193648. NRAGE signals death through JNK.
R-MMU-194840. Rho GTPase cycle.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-3928665. EPH-ephrin mediated repulsion of cells.
R-MMU-416482. G alpha (12/13) signalling events.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: T-cell lymphoma invasion and metastasis 1Imported Submitted name: T-lymphoma invasion and metastasis-inducing protein 1Imported
Gene namesⁱ	Name:Tiam1Imported ORF Names:mCG_129085Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 16

Organism-specific databases

MGIⁱ	MGI:103306. Tiam1.

Subcellular locationⁱ

GO - Cellular componentⁱ

axonal growth cone Source: Ensembl
cell-cell contact zone Source: Ensembl
cytosol Source: Ensembl
dendritic spine Source: Ensembl
extrinsic component of cytoplasmic side of plasma membrane Source: Ensembl
main axon Source: Ensembl
microtubule Source: Ensembl
neuronal cell body Source: Ensembl
nucleus Source: Ensembl
postsynaptic density Source: Ensembl
ruffle membrane Source: Ensembl

Complete GO annotation...

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000002489.

Bgeeⁱ

ENSMUSG00000002489.

Interactionⁱ

GO - Molecular functionⁱ

microtubule binding Source: Ensembl
Rac GTPase binding Source: Ensembl
receptor tyrosine kinase binding Source: Ensembl

Complete GO annotation...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	439 – 547	PHInterPro annotationAdd BLAST	109
Domainⁱ	765 – 832	RBD (Ras-binding)InterPro annotationAdd BLAST	68
Domainⁱ	845 – 908	PDZ (DHR)InterPro annotationAdd BLAST	64
Domainⁱ	1040 – 1234	DH (DBL-homology)InterPro annotationAdd BLAST	195

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	553 – 580	Sequence analysisAdd BLAST		28

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410ITS1. Eukaryota. ENOG410XPCM. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118925.
KEGG Orthology (KO) More...KOⁱ	K05731.
OMAⁱ	TVIWLNP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00CZ.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 2 hits.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR001478. PDZ. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR003116. RBD_dom. IPR033360. TIAM1.
PANTHERⁱ	PTHR22826:SF183. PTHR22826:SF183. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00595. PDZ. 1 hit. PF00169. PH. 2 hits. PF02196. RBD. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00228. PDZ. 1 hit. SM00233. PH. 2 hits. SM00455. RBD. 1 hit. SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF48065. SSF48065. 1 hit. SSF50156. SSF50156. 1 hit. SSF50729. SSF50729. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50106. PDZ. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50898. RBD. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

G3UWG2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGNAESQNVD HEFYGEKHAS LGRKHTSRSL RLSHKTRRTR HASSGKAIHR 
        60         70         80         90        100
NSEVSTRSSS TPSIPQSLAE NGLEPFSQEG ALDDFGDPIW VDRVDMGLRP 
       110        120        130        140        150
VSYTDSSVTP SVDGSIVLTA ASVQSMPDSE ESRLYGDDAT YLAEGGRRQC 
       160        170        180        190        200
PYTSNGPTFM ETASFKKKRS KSADIWREDS LEFSLSDLSQ EHLTSNEEIL 
       210        220        230        240        250
GSAEEKDCEE ARGMETEASP RQLSTCQRAN SLGDLYAQKN SGVKANGGPR 
       260        270        280        290        300
NRFSSYCRNL VSDIPDLAKH KMPPAAAEET PPYSNYNTLP CRKSHCLSEG 
       310        320        330        340        350
ATNPQISLSK SMQGRRAKTT QDVNTGEGSE FADSGIEGAT TDTDLLSRRS 
       360        370        380        390        400
NATNSSYSPP TGRAFVGSDS GSSSTGDAAR QGVYENFRRE LEMSTTNSES 
       410        420        430        440        450
LEEAGSAHSD EQSSGTLSSP GQSDILLTAA QGTVRKAGAL AVKNFLVHKK 
       460        470        480        490        500
NKKVESATRR KWKHYWVSLK GCTLFFYETD GRSGIDHNSV PKHAVWVENS 
       510        520        530        540        550
IVQAVPEHPK KDFVFCLSNS LGDAFLFQTT SQTELENWIT AIHSACAAAV 
       560        570        580        590        600
ARHHHKEDTL RLLKSEIKKL EQKIDMDEKM KKMGEMQLSS VTDSKKKKTI 
       610        620        630        640        650
LDQIFVWEQN LEQFQMDLFR FRCYLASLQG GELPNPKRLL AFASRPTKVA 
       660        670        680        690        700
MGRLGIFSVS SFHALVAART GEIGVRRRTQ AMSRSASKRR SRFSSLWGLD 
       710        720        730        740        750
TTSKKKQGRP TINQVFGEGT DAVKRSLEGI FDDTVPDGKR EKEVVLPSVH 
       760        770        780        790        800
QHNPDCDIWV HEYFTPSWFC LPNNQPALTV VRPGDTARDT LELICKTHQL 
       810        820        830        840        850
DHSAHYLRLK FLMENRVQFY IPQPEEDIYE LLYKEIEICP KVTQNIHIEK 
       860        870        880        890        900
SDAAADNYGF LLSSVDEDGI RRLYVNSVKE TGLASKKGLK AGDEILEINN 
       910        920        930        940        950
RAAGTLNSSM LKDFLSQPSL GLLVRTYPEP EGGVELLENP PHRVDGPVDL 
       960        970        980        990       1000
GESPLAFLTS NPGHSLSSEQ GSSAETAPEE GEGPDLESSD ETDHSSKSTE 
      1010       1020       1030       1040       1050
QVAAFCRSLH EMSPSDSSPS PQDATSPQLA TTRQLSDADK LRKVICELLE 
      1060       1070       1080       1090       1100
TERTYVKDLN CLMERYLKPL QKETFLTQDE LDVLFGNLTE MVEFQVEFLK 
      1110       1120       1130       1140       1150
TLEDGVRLVP DLEKLEKVDQ FKKVLFSLGG SFLYYADRFK LYSAFCASHT 
      1160       1170       1180       1190       1200
KVPKVLVKAK TDTAFKAFLD AQNPRQQHSS TLESYLIKPI QRVLKYPLLL 
      1210       1220       1230       1240       1250
RELFALTDAE SEEHYHLDVA IKTMNKVASH INEMQKIHEE FGAVFDQLIA 
      1260       1270       1280       1290       1300
EQTGEKKEVA DLSMGDLLLH TSVIWLNPPA SLGKWKKEPE LAAFVFKTAV 
      1310       1320       1330       1340       1350
VLVYKDGSKQ KKKLVGSHRL SIYEEWDPFR FRHMIPTEAL QVRALPSADA 
      1360       1370       1380       1390       1400
EANAVCEIVH VKSESEGRPE RVFHLCCSSP ESRKDFLKSV HSILRDKHRR 
      1410       1420       1430       1440       1450
QLLKTESLPS AQQYVPFGGK RLCALKGARP AMSRAVSAPS KSLGRRRRRL 
      1460       1470       1480       1490       1500
ARNRFTIDSD AISASSPEKE PQQPAGGGDT DRWVEEQFDL AQYEEQDDIK 
      1510       1520       1530       1540       1550
ETDILSDDDE FCESLKGASV DRDLQEQLQA ASISQRARGR RTLDSHASRM 
      1560       1570       1580       1590 
TQLKKQAALS GINGGLESAS EEVIWVRRED FAPSRKLNTE I

Length:1,591

Mass (Da):177,448

Last modified:November 16, 2011 - v1

Checksum:ⁱ93E7AF65A974F2CD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC087840 Genomic DNA. No translation available. AC102908 Genomic DNA. No translation available. AC122218 Genomic DNA. No translation available. CH466521 Genomic DNA. Translation: EDK98383.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001139358.1. NM_001145886.1. NP_033410.2. NM_009384.3. XP_006523041.1. XM_006522978.3. XP_006523043.1. XM_006522980.3. XP_006523045.1. XM_006522982.3. XP_011244414.1. XM_011246112.2. XP_017172425.1. XM_017316936.1.
UniGeneⁱ	Mm.310902.

Genome annotation databases

Ensemblⁱ	ENSMUST00000002588; ENSMUSP00000002588; ENSMUSG00000002489. ENSMUST00000114124; ENSMUSP00000109759; ENSMUSG00000002489. ENSMUST00000163370; ENSMUSP00000132137; ENSMUSG00000002489.
GeneIDⁱ	21844.
KEGGⁱ	mmu:21844.
UCSC genome browser More...UCSCⁱ	uc007zvu.2. mouse.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC087840 Genomic DNA. No translation available. AC102908 Genomic DNA. No translation available. AC122218 Genomic DNA. No translation available. CH466521 Genomic DNA. Translation: EDK98383.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001139358.1. NM_001145886.1. NP_033410.2. NM_009384.3. XP_006523041.1. XM_006522978.3. XP_006523043.1. XM_006522980.3. XP_006523045.1. XM_006522982.3. XP_011244414.1. XM_011246112.2. XP_017172425.1. XM_017316936.1.
UniGeneⁱ	Mm.310902.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000002588; ENSMUSP00000002588; ENSMUSG00000002489. ENSMUST00000114124; ENSMUSP00000109759; ENSMUSG00000002489. ENSMUST00000163370; ENSMUSP00000132137; ENSMUSG00000002489.
GeneIDⁱ	21844.
KEGGⁱ	mmu:21844.
UCSC genome browser More...UCSCⁱ	uc007zvu.2. mouse.

Organism-specific databases

CTDⁱ	7074.
MGIⁱ	MGI:103306. Tiam1.

Phylogenomic databases

eggNOGⁱ	ENOG410ITS1. Eukaryota. ENOG410XPCM. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118925.
KEGG Orthology (KO) More...KOⁱ	K05731.
OMAⁱ	TVIWLNP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00CZ.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-193648. NRAGE signals death through JNK. R-MMU-194840. Rho GTPase cycle. R-MMU-3928662. EPHB-mediated forward signaling. R-MMU-3928665. EPH-ephrin mediated repulsion of cells. R-MMU-416482. G alpha (12/13) signalling events.

Reactomeⁱ

R-MMU-193648. NRAGE signals death through JNK.
R-MMU-194840. Rho GTPase cycle.
R-MMU-3928662. EPHB-mediated forward signaling.
R-MMU-3928665. EPH-ephrin mediated repulsion of cells.
R-MMU-416482. G alpha (12/13) signalling events.

Miscellaneous databases

ChiTaRSⁱ	Tiam1. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000002489.

Bgeeⁱ

ENSMUSG00000002489.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 2 hits.
InterProⁱ	View protein in InterPro IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR001478. PDZ. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR003116. RBD_dom. IPR033360. TIAM1.
PANTHERⁱ	PTHR22826:SF183. PTHR22826:SF183. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00595. PDZ. 1 hit. PF00169. PH. 2 hits. PF02196. RBD. 1 hit. PF00621. RhoGEF. 1 hit.
SMARTⁱ	View protein in SMART SM00228. PDZ. 1 hit. SM00233. PH. 2 hits. SM00455. RBD. 1 hit. SM00325. RhoGEF. 1 hit.
SUPFAMⁱ	SSF48065. SSF48065. 1 hit. SSF50156. SSF50156. 1 hit. SSF50729. SSF50729. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50106. PDZ. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50898. RBD. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G3UWG2_MOUSE
Accessionⁱ	G3UWG2Primary (citable) accession number: G3UWG2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 16, 2011
	Last sequence update:	November 16, 2011
	Last modified:	July 5, 2017
	This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - G3UWG2 (G3UWG2_MOUSE)

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T-cell lymphoma invasion and metastasis 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ