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Protein
Submitted name:

Cytochrome P450 11B2, mitochondrial

Gene

Cyp11b2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. steroid 11-beta-monooxygenase activity Source: MGI

GO - Biological processi

  1. aldosterone biosynthetic process Source: MGI
  2. C21-steroid hormone biosynthetic process Source: MGI
  3. cortisol biosynthetic process Source: MGI
  4. drinking behavior Source: MGI
  5. ion homeostasis Source: MGI
  6. regulation of blood pressure Source: MGI
  7. regulation of blood volume by renal aldosterone Source: MGI
  8. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P450 11B2, mitochondrialImported
Submitted name:
MCG2779, isoform CRA_bImported
Gene namesi
Name:Cyp11b2Imported
ORF Names:mCG_2779Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:88584. Cyp11b2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119243.
KOiK00497.
OMAiISEYANR.
OrthoDBiEOG7ZWD2T.
TreeFamiTF105094.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3UWE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMALRVTAD VWLARPWQCL HRTRALGTTA TLAPKTLQPF EAIPQYSRNK
60 70 80 90 100
WLKMIQILRE QGQENLHLEM HQVFRELGPI FRHSVGKTQI VSVMLPEDAE
110 120 130 140 150
KLHQVESMLP RRMHLEPWVA HRELRGLRRG VFLLNGPEWR LNRLRLNRNV
160 170 180 190 200
LSPKAVQKFV PMVDMVARDF LETLKEKVLQ NARGSLTMDV QQSLFNYTIE
210 220 230 240 250
ASNFALFGER LGLLGHDLSP GSLKFIHALH SMFKSTSQLL FLPKSLTRWT
260 270 280 290 300
STRVWKEHFD AWDVISEYAN RCIWKVHQEL RLGSSQTYSG IVAELISQGS
310 320 330 340 350
LPLDAIKANS MELTAGSVDT TAIPLVMTLF ELARNPDVQK ALRQESLAAE
360 370 380 390 400
ASIAANPQKA MSDLPLLRAA LKETLRLYPV GGFLERILSS DLVLQNYHVP
410 420 430 440 450
AGTLVLLYLY SMGRNPAVFP RPERYMPQRW LERKRSFQHL AFGFGVRQCL
460 470 480 490 500
GRRLAEVEMM LLLHHILKTF QVETLRQEDV QMAYRFVLMP SSSPVLTFRP

VS
Length:502
Mass (Da):57,575
Last modified:November 16, 2011 - v1
Checksum:iBCAFFF3EE471ED37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139671 Genomic DNA. No translation available.
CH466545 Genomic DNA. Translation: EDL29457.1.
RefSeqiNP_034121.3. NM_009991.3.
UniGeneiMm.377079.

Genome annotation databases

EnsembliENSMUST00000167634; ENSMUSP00000131503; ENSMUSG00000022589.
GeneIDi13072.
KEGGimmu:13072.
UCSCiuc007wgf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC139671 Genomic DNA. No translation available.
CH466545 Genomic DNA. Translation: EDL29457.1.
RefSeqiNP_034121.3. NM_009991.3.
UniGeneiMm.377079.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167634; ENSMUSP00000131503; ENSMUSG00000022589.
GeneIDi13072.
KEGGimmu:13072.
UCSCiuc007wgf.2. mouse.

Organism-specific databases

CTDi1585.
MGIiMGI:88584. Cyp11b2.

Phylogenomic databases

GeneTreeiENSGT00760000119243.
KOiK00497.
OMAiISEYANR.
OrthoDBiEOG7ZWD2T.
TreeFamiTF105094.

Miscellaneous databases

NextBioi283008.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiG3UWE4_MOUSE
AccessioniPrimary (citable) accession number: G3UWE4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 29, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.