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G3UWE4

- G3UWE4_MOUSE

UniProt

G3UWE4 - G3UWE4_MOUSE

Protein
Submitted name:

Cytochrome P450 11B2, mitochondrial

Gene

Cyp11b2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. steroid 11-beta-monooxygenase activity Source: MGI

    GO - Biological processi

    1. aldosterone biosynthetic process Source: MGI
    2. drinking behavior Source: MGI
    3. ion homeostasis Source: MGI
    4. regulation of blood volume by renal aldosterone Source: MGI
    5. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: MGI

    Keywords - Molecular functioni

    MonooxygenaseUniRule annotation, Oxidoreductase

    Keywords - Ligandi

    HemeUniRule annotation, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cytochrome P450 11B2, mitochondrialImported
    Submitted name:
    MCG2779, isoform CRA_bImported
    Gene namesi
    Name:Cyp11b2Imported
    ORF Names:mCG_2779Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:88584. Cyp11b2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117408.
    KOiK00497.
    OMAiTEASHFA.
    OrthoDBiEOG7ZWD2T.
    TreeFamiTF105094.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002399. Cyt_P450_mitochondrial.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00408. MITP450.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3UWE4-1 [UniParc]FASTAAdd to Basket

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    MAMALRVTAD VWLARPWQCL HRTRALGTTA TLAPKTLQPF EAIPQYSRNK    50
    WLKMIQILRE QGQENLHLEM HQVFRELGPI FRHSVGKTQI VSVMLPEDAE 100
    KLHQVESMLP RRMHLEPWVA HRELRGLRRG VFLLNGPEWR LNRLRLNRNV 150
    LSPKAVQKFV PMVDMVARDF LETLKEKVLQ NARGSLTMDV QQSLFNYTIE 200
    ASNFALFGER LGLLGHDLSP GSLKFIHALH SMFKSTSQLL FLPKSLTRWT 250
    STRVWKEHFD AWDVISEYAN RCIWKVHQEL RLGSSQTYSG IVAELISQGS 300
    LPLDAIKANS MELTAGSVDT TAIPLVMTLF ELARNPDVQK ALRQESLAAE 350
    ASIAANPQKA MSDLPLLRAA LKETLRLYPV GGFLERILSS DLVLQNYHVP 400
    AGTLVLLYLY SMGRNPAVFP RPERYMPQRW LERKRSFQHL AFGFGVRQCL 450
    GRRLAEVEMM LLLHHILKTF QVETLRQEDV QMAYRFVLMP SSSPVLTFRP 500
    VS 502
    Length:502
    Mass (Da):57,575
    Last modified:November 16, 2011 - v1
    Checksum:iBCAFFF3EE471ED37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC139671 Genomic DNA. No translation available.
    CH466545 Genomic DNA. Translation: EDL29457.1.
    RefSeqiNP_034121.3. NM_009991.3.
    UniGeneiMm.377079.

    Genome annotation databases

    EnsembliENSMUST00000167634; ENSMUSP00000131503; ENSMUSG00000022589.
    GeneIDi13072.
    KEGGimmu:13072.
    UCSCiuc007wgf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC139671 Genomic DNA. No translation available.
    CH466545 Genomic DNA. Translation: EDL29457.1 .
    RefSeqi NP_034121.3. NM_009991.3.
    UniGenei Mm.377079.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000167634 ; ENSMUSP00000131503 ; ENSMUSG00000022589 .
    GeneIDi 13072.
    KEGGi mmu:13072.
    UCSCi uc007wgf.2. mouse.

    Organism-specific databases

    CTDi 1585.
    MGIi MGI:88584. Cyp11b2.

    Phylogenomic databases

    GeneTreei ENSGT00750000117408.
    KOi K00497.
    OMAi TEASHFA.
    OrthoDBi EOG7ZWD2T.
    TreeFami TF105094.

    Miscellaneous databases

    NextBioi 283008.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002399. Cyt_P450_mitochondrial.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00408. MITP450.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiG3UWE4_MOUSE
    AccessioniPrimary (citable) accession number: G3UWE4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3