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Protein
Submitted name:

MCG140437, isoform CRA_d

Gene

Myh2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • actin-mediated cell contraction Source: MGI
  • muscle contraction Source: MGI
  • plasma membrane repair Source: MGI
  • response to activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, MyosinSAAS annotation

Keywords - Ligandi

Actin-bindingSAAS annotation, ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_344463. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Submitted name:
MCG140437, isoform CRA_dImported
Submitted name:
Protein Myh2Imported
Gene namesi
Name:Myh2Imported
ORF Names:mCG_140437Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1339710. Myh2.

Subcellular locationi

GO - Cellular componenti

  • A band Source: MGI
  • actomyosin contractile ring Source: MGI
  • cell-cell junction Source: MGI
  • Golgi apparatus Source: MGI
  • muscle myosin complex Source: MGI
  • myofibril Source: MGI
  • protein complex Source: MGI
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018641.

Family & Domainsi

Sequence similaritiesi

Contains IQ domain.SAAS annotation
Contains myosin motor domain.SAAS annotation

Keywords - Domaini

Coiled coilSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118919.
KOiK10352.
OMAiHEMERRV.
OrthoDBiEOG7RBZ7G.
TreeFamiTF314375.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3UW82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDAEMAVF GEAAPYLRKS EKERIEAQNR PFDAKTSVFV AEPKESFVKG
60 70 80 90 100
TIQSKDAGKV TVKTEAGATL TVKEDQIFPM NPPKYDKIED MAMMTHLHEP
110 120 130 140 150
AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNPEVV AAYRGKKRQE
160 170 180 190 200
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA
210 220 230 240 250
VTGDKKKEEA TSGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF
260 270 280 290 300
IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QITSNKKPEL
310 320 330 340 350
IEMLLITTNP YDYPFVSQGE ISVASIDDQE ELMATDSAID ILGFTNDEKV
360 370 380 390 400
SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QGLNSADLLK
410 420 430 440 450
ALCYPRVKVG NEYVTKGQTV EQVTNAVGAL AKAMYEKMFL WMVTRINQQL
460 470 480 490 500
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE
510 520 530 540 550
QEEYKKEGIE WTFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS
560 570 580 590 600
FKNKLYEQHL GKSANFQKPK VVKGKAEAHF SLIHYAGTVD YNITGWLDKN
610 620 630 640 650
KDPLNETVVG LYQKSSVKTL AYLFSGAQTA EAEASSGGAA KKGAKKKGSS
660 670 680 690 700
FQTVSALFRE NLNKLMTNLR STHPHFVRCI IPNETKTPGA MEHELVLHQL
710 720 730 740 750
RCNGVLEGIR ICRKGFPSRI LYADFKQRYK VLNASAIPEG QYIDSKKASE
760 770 780 790 800
KLLGSIDIDH TQYKFGHTKV FFKAGLLGLL EEMRDDKLAQ LITRTQAMCR
810 820 830 840 850
GFLARVEYQK MVERRESIFC IQYNIRAFMN VKHWPWMKLF FKIKPLLKSA
860 870 880 890 900
ETEKEMATMK EEFQKTKDDL AKSEAKRKEL EEKMVSLLKE KNDLQLQVQA
910 920 930 940 950
EAEGLADAEE RCDQLIKTKI QLEAKIKEVT ERAEDEEEIN AELTAKKRKL
960 970 980 990 1000
EDECSELKKD IDDLELTLAK VEKEKHATEN KVKNLTEEMA GLDETIAKLT
1010 1020 1030 1040 1050
KEKKALQEAH QQTLDDLQAE EDKVNTLTKA KIKLEQQVDD LEGSLEQEKK
1060 1070 1080 1090 1100
LRMDLERAKR KLEGDLKLAQ ESIMDIENEK QQLDERLKKK EFEMSNLQSK
1110 1120 1130 1140 1150
IEDEQAIGIQ LQKKIKELQA RIEELEEEIE AERASRAKAE KQRSDLSREL
1160 1170 1180 1190 1200
EEISERLEEA GGATSAQIEM NKKREAEFQK MRRDLEEATL QHEATAATLR
1210 1220 1230 1240 1250
KKHADSVAEL GEQIDNLQRV KQKLEKEKSE MKMEIDDLAS NVETVSKAKG
1260 1270 1280 1290 1300
NLEKMCRTLE DQVSELKSKE EEQQRLINDL TTQRGRLQTE SGEFSRQLDE
1310 1320 1330 1340 1350
KEALVSQLSR GKQAFTQQIE ELKRQLEEEV KAKNALAHAL QSSRHDCDLL
1360 1370 1380 1390 1400
REQYEEEQES KAELQRALSK ANSEVAQWRT KYETDAIQRT EELEEAKKKL
1410 1420 1430 1440 1450
AQRLQAAEEH VEAVNAKCAS LEKTKQRLQN EVEDLMLDVE RTNAACAALD
1460 1470 1480 1490 1500
KKQRNFDKIL AEWKQKYEET HAELEASQKE ARSLGTELFK MKNAYEESLD
1510 1520 1530 1540 1550
QLETLKRENK NLQQEISDLT EQIAEGGKRI HELEKIKKQV EQEKCELQAA
1560 1570 1580 1590 1600
LEEAEASLEH EEGKILRIQL ELNQVKSEID RKIAEKDEEI DQLKRNHIRV
1610 1620 1630 1640 1650
VESMQSTLDA EIRSRNDAIR IKKKMEGDLN EMEIQLNHSN RMAAEALRNY
1660 1670 1680 1690 1700
RNTQGILKDT QLHLDDALRG QEDLKEQLAM VERRANLLQA EIEELRATLE
1710 1720 1730 1740 1750
QTERSRKIAE QELLDASERV QLLHTQNTSL INTKKKLETD ISQIQGEMED
1760 1770 1780 1790 1800
IVQEARNAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KNMEQTVKDL
1810 1820 1830 1840 1850
QLRLDEAEQL ALKGGKKQIQ KLEARVRELE GEVESEQKRN AEAVKGLRKH
1860 1870 1880 1890 1900
ERRVKELTYQ TEEDRKNILR LQDLVDKLQA KVKSYKRQAE EAEEQSNTNL
1910 1920 1930 1940
SKFRKIQHEL EEAEERADIA ESQVNKLRVK SREVHTKIIS EE
Length:1,942
Mass (Da):223,219
Last modified:November 16, 2011 - v1
Checksum:i9087D534CB3C4AD7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596129 Genomic DNA. No translation available.
CH466601 Genomic DNA. Translation: EDL10428.1.
RefSeqiNP_001034634.2. NM_001039545.2.
UniGeneiMm.422801.

Genome annotation databases

EnsembliENSMUST00000018641; ENSMUSP00000018641; ENSMUSG00000033196.
ENSMUST00000170159; ENSMUSP00000129544; ENSMUSG00000033196.
GeneIDi17882.
KEGGimmu:17882.
UCSCiuc007jmd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596129 Genomic DNA. No translation available.
CH466601 Genomic DNA. Translation: EDL10428.1.
RefSeqiNP_001034634.2. NM_001039545.2.
UniGeneiMm.422801.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018641.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018641; ENSMUSP00000018641; ENSMUSG00000033196.
ENSMUST00000170159; ENSMUSP00000129544; ENSMUSG00000033196.
GeneIDi17882.
KEGGimmu:17882.
UCSCiuc007jmd.2. mouse.

Organism-specific databases

CTDi4620.
MGIiMGI:1339710. Myh2.

Phylogenomic databases

GeneTreeiENSGT00760000118919.
KOiK10352.
OMAiHEMERRV.
OrthoDBiEOG7RBZ7G.
TreeFamiTF314375.

Enzyme and pathway databases

ReactomeiREACT_344463. Regulation of actin dynamics for phagocytic cup formation.

Miscellaneous databases

NextBioi292681.
PROiG3UW82.
SOURCEiSearch...

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiG3UW82_MOUSE
AccessioniPrimary (citable) accession number: G3UW82
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 24, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.