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Protein

Neuropilin

Gene

NRP1

Organism
Loxodonta africana (African elephant)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi193CalciumUniRule annotation1
Metal bindingi207CalciumUniRule annotation1
Metal bindingi248CalciumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinUniRule annotation, ReceptorUniRule annotation
Biological processDifferentiationUniRule annotation, NeurogenesisUniRule annotation
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NeuropilinUniRule annotation
Gene namesi
Name:NRP1Imported
OrganismiLoxodonta africana (African elephant)Imported
Taxonomic identifieri9785 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeLoxodonta
Proteomesi
  • UP000007646 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei855 – 880HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500345412120 – 921NeuropilinSequence analysisAdd BLAST902

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 52UniRule annotation
Disulfide bondi80 ↔ 102UniRule annotation
Disulfide bondi145 ↔ 171UniRule annotation
Disulfide bondi204 ↔ 226UniRule annotation
Disulfide bondi273 ↔ 422UniRule annotation
Disulfide bondi429 ↔ 581UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9785.ENSLAFP00000002520

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 139CUBInterPro annotationAdd BLAST115
Domaini145 – 263CUBInterPro annotationAdd BLAST119
Domaini273 – 422F5/8 type CInterPro annotationAdd BLAST150
Domaini429 – 581F5/8 type CInterPro annotationAdd BLAST153
Domaini646 – 809MAMInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the neuropilin family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IE8T Eukaryota
ENOG410YRBE LUCA
GeneTreeiENSGT00910000143988
InParanoidiG3SRK3
KOiK06724
OMAiLYCACWH
OrthoDBiEOG091G017M
TreeFamiTF316506

Family and domain databases

CDDicd00041 CUB, 2 hits
cd06263 MAM, 1 hit
Gene3Di2.60.120.260, 2 hits
2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR000421 FA58C
IPR008979 Galactose-bd-like_sf
IPR000998 MAM_dom
IPR014648 Neuropilin
IPR022579 Neuropilin_C
IPR027146 NRP1
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR44185 PTHR44185, 1 hit
PTHR44185:SF1 PTHR44185:SF1, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF11980 DUF3481, 1 hit
PF00754 F5_F8_type_C, 2 hits
PF00629 MAM, 1 hit
PIRSFiPIRSF036960 Neuropilin, 1 hit
PRINTSiPR00020 MAMDOMAIN
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00231 FA58C, 2 hits
SM00137 MAM, 1 hit
SUPFAMiSSF49785 SSF49785, 2 hits
SSF49854 SSF49854, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01285 FA58C_1, 2 hits
PS01286 FA58C_2, 2 hits
PS50022 FA58C_3, 2 hits
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit

Sequencei

Sequence statusi: Complete.

G3SRK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERGLLLLCA ALALALASAF RNDKCGGTIK IENPGYLTSP GYPHSYHPSE
60 70 80 90 100
KCEWLIQAPY PYQRIMINFN PHFDLEDRDC KYDYVEVIDG DNPNGRLWGK
110 120 130 140 150
FCGKIAPSPV VSLGPFLFIR FVSDYETHGA GFSIRYEIFK RGPECSQNYT
160 170 180 190 200
TPSGVIKSPG FPEKYPNSLE CTYIIFAPKM SEILLEFESF DLEPDSNPPG
210 220 230 240 250
GIFCRYDRLE IWDGFPEVGP HIGRYCGQKT PGRIRSSSGI LSMVFYTDSA
260 270 280 290 300
IAKEGFSANY SVLQSSVSED FKCMEALGME SGEIHSDQIT ASSQYSTNWS
310 320 330 340 350
AERSRLNYPE NGWTPGEDSY REWIQVDLGH LRFITAVGTQ GAISKETKKK
360 370 380 390 400
YYVRTYRIDI SSNGEDWITI KEGNKPVIFQ GNTNPTDVVF GIFPKPLITR
410 420 430 440 450
FVRIKPMTWE TGISMRFEVY GCKITDYPCS GMLGMVSGLI SDSQITASNQ
460 470 480 490 500
ADRNWMPENI RLVTSRSGWA LPPAPHTYVN QWLQVDLGEE KIVRGVIIQG
510 520 530 540 550
GKHRENKVFM RKFKIGYSNN GSDWKMIMDD SKRKAKSFEG NNNYDTPELR
560 570 580 590 600
TFPPLSTRFI RIYPERATHG GLGLRMELLG CEVEVPTAGP TTPNGNPIDE
610 620 630 640 650
CDDDQANCHS GTGDDFQLTG GTTVLTTEKP TVLDSTIQSE FPTYGFNCEF
660 670 680 690 700
GWGSHKTFCH WEHDNHVQLK WSVLTSKTGP IQDHTGDGNF IYSQADENQK
710 720 730 740 750
GKVARLVSPV VYSQNSAHCL TFWYHMSGSH VGTLRVKLRY QKPEEYDQLV
760 770 780 790 800
WMAIGHQGDH WKEGRVLLHK SLKLYQVIFE GEIGKGNLGG IAVDDISINN
810 820 830 840 850
HISQEDCAKP ADLDKKHPEN KIDEAGSTPG YKGTEDGEEN ISRKPGNVLK
860 870 880 890 900
TLDPILITII AMSALGVLLG AVCGVVLYCA CWHNGMSERN LSALENYNFE
910 920
LVDGVKLKKD KLTTQSTYSE A
Length:921
Mass (Da):103,209
Last modified:November 16, 2011 - v1
Checksum:i83CC4338608F6EF7
GO

Sequence databases

RefSeqiXP_003420766.1, XM_003420718.2

Genome annotation databases

EnsembliENSLAFT00000003025; ENSLAFP00000002520; ENSLAFG00000003025
GeneIDi100664313
KEGGilav:100664313

Similar proteinsi

Entry informationi

Entry nameiG3SRK3_LOXAF
AccessioniPrimary (citable) accession number: G3SRK3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 25, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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