G3SPY9 (G3SPY9_LOXAF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800

Gene names

Name:

KYNU Ensembl ENSLAFP00000001817

Organism

Loxodonta africana (African elephant) [Reference proteome] Ensembl ENSLAFP00000001817

Taxonomic identifier

9785 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Afrotheria › Proboscidea › Elephantidae › Loxodonta

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800
Catalytic activity	L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800
Cofactor	Pyridoxal phosphate By similarity. PIRNR PIRNR038800
Pathway	Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800
Subunit structure	Homodimer By similarity. PIRNR PIRNR038800
Subcellular location	Cytoplasm By similarity PIRNR PIRNR038800.
Sequence similarities	Belongs to the kynureninase family. PIRNR PIRNR038800
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSLAFP00000001817

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis PIRNR PIRNR038800
Cellular component	Cytoplasm PIRNR PIRNR038800
Ligand	Pyridoxal phosphate PIRNR PIRNR038800
Molecular function	Hydrolase PIRNR PIRNR038800
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	L-kynurenine catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway NAD biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway anthranilate metabolic process Inferred from electronic annotation. Source: Compara quinolinate biosynthetic process Inferred from electronic annotation. Source: Compara response to interferon-gamma Inferred from electronic annotation. Source: Compara response to vitamin B6 Inferred from electronic annotation. Source: Compara tryptophan catabolic process Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara mitochondrion Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	kynureninase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G3SPY9 [UniParc]. Last modified November 16, 2011. Version 1. Checksum: 5085A0FEF9A0DB29	FASTA	462	52,137
	10 20 30 40 50 60 MEPSPLELPA DTIRRIAAEL RCSPTDVQVA LRLDEEDKLR HFREYFYIPK KQDLPPIDLS 70 80 90 100 110 120 LVNKDENAIY FLGNSLGLQP KMVKTYLEEE LDKWAKIGAY GHEVGKRPWI TGDESITGLM 130 140 150 160 170 180 IDIVGANEKE IVLMNGLTVN LHLLLLSFFK PTPKRYKILL EAKAFPSDHY AIESQLQLHG 190 200 210 220 230 240 LNVEKSMRII KPREGEETLR MEDILDVIEK EGDSIAVILF SGVHFYTGQL FNIPAITKAG 250 260 270 280 290 300 QAKGCFVGFD LAHAAGNVEL HLHDWGVDFA CWCSYKYLNS GAGGLAGAFV HEKHAHTIKP 310 320 330 340 350 360 ALVGWFGHEL NTRFKMDNKL QLIPGATGFR ISNPPILLVC SLHASLEIFK QATMQALRRK 370 380 390 400 410 420 SVLLTGYLEY LIKNYHNKDK AESKKPVVNI ITPPHIEERG CQLTLTFSAP MKYVFQELEK 430 440 450 460 RGVVCDKREP NGIRVAPVPL YNSFHDVYKF VSLLISVLDS TE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Genome Sequence of Loxodonta africana (African elephant)." Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K. Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate ISIS603380 Ensembl ENSLAFP00000001817.
[2]	Ensembl Submitted (SEP-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSLAFT00000002172; ENSLAFP00000001817; ENSLAFG00000002172.
Phylogenomic databases
GeneTree	ENSGT00390000008033.
OMA	MLTHVNY.
Enzyme and pathway databases
UniPathway	UPA00253; UER00329. UPA00334; UER00455.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR010111. Kynureninase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR14084. PTHR14084. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
PIRSF	PIRSF038800. KYNU. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01814. kynureninase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

G3SPY9_LOXAF

Accession

Primary (citable) accession number: G3SPY9

Entry history

Integrated into UniProtKB/TrEMBL:	November 16, 2011
Last sequence update:	November 16, 2011
Last modified:	April 3, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)