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Protein
Submitted name:

BCL2, apoptosis regulator

Gene

BCL2

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
BCL2, apoptosis regulatorImported
Gene namesi
Name:BCL2Imported
OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Chromosome 18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei215 – 236HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSGGOG00000000790.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000028034.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 30BH4_2InterPro annotationAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 30BH4PROSITE-ProRule annotationAdd BLAST20

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00530000062935.
InParanoidiG3SIU4.
KOiK02161.
OMAiEWDAGDA.
OrthoDBiEOG091G0OCU.
TreeFamiTF315834.

Family and domain databases

Gene3Di1.10.437.10. 1 hit.
InterProiView protein in InterPro
IPR013278. Apop_reg_Bcl2.
IPR002475. Bcl2-like.
IPR004725. Bcl2/BclX.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR020728. Bcl2_BH3_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR036834. Blc2-like_sf.
IPR026298. Blc2_fam.
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF11. PTHR11256:SF11. 1 hit.
PfamiView protein in Pfam
PF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
PRINTSiPR01863. APOPREGBCL2.
PR01862. BCL2FAMILY.
SMARTiView protein in SMART
SM00265. BH4. 1 hit.
SUPFAMiSSF56854. SSF56854. 1 hit.
TIGRFAMsiTIGR00865. bcl-2. 1 hit.
PROSITEiView protein in PROSITE
PS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01259. BH3. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.

Sequencei

Sequence statusi: Complete.

G3SIU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAVPP GAAPAPGIFS
60 70 80 90 100
SQPGHTPHPA ASRDRVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA
110 120 130 140 150
GDDFSRRYRR DFAEMSSQLH LTPFTARGRF ATVVEELFRD GVNWGRIVAF
160 170 180 190 200
FEFGGVMCVE SVNREMSPLV DNIALWMTEY LNRHLHTWIQ DNGGWDAFVE
210 220 230
LYGPSMRPLF DFSWLSLKTL LSLALVGACI TLGAYLGHK
Length:239
Mass (Da):26,353
Last modified:November 16, 2011 - v1
Checksum:i83A3D8BED3BC55E7
GO

Sequence databases

RefSeqiXP_004059549.1. XM_004059501.2.

Genome annotation databases

EnsembliENSGGOT00000033135; ENSGGOP00000028034; ENSGGOG00000000790.
GeneIDi101136123.
KEGGiggo:101136123.

Similar proteinsi

Entry informationi

Entry nameiG3SIU4_GORGO
AccessioniPrimary (citable) accession number: G3SIU4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 25, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported