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Protein

Purine nucleoside phosphorylase

Gene

PNP

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33PhosphateUniRule annotation1
Binding sitei64PhosphateUniRule annotation1
Binding sitei116Phosphate; via amide nitrogenUniRule annotation1
Binding sitei201Purine nucleosideUniRule annotation1
Binding sitei220PhosphateUniRule annotation1
Binding sitei243Purine nucleosideUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00606

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Inosine-guanosine phosphorylaseUniRule annotation
Gene namesi
Name:PNPImported
OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSGGOG00000002126

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 275PNP_UDP_1InterPro annotationAdd BLAST249

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 86Phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000074740
KOiK03783

Family and domain databases

InterProiView protein in InterPro
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR011270 Pur_Nuc_Pase_Ino/Guo-sp
IPR011268 Purine_phosphorylase
IPR018099 Purine_phosphorylase-2_CS
PANTHERiPTHR11904 PTHR11904, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
PIRSFiPIRSF000477 PurNPase, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01700 PNPH, 1 hit
TIGR01697 PNPH-PUNA-XAPA, 1 hit
PROSITEiView protein in PROSITE
PS01240 PNP_MTAP_2, 1 hit

Sequencei

Sequence statusi: Complete.

G3SH63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENGYTYEDY KNTAEWLLSH TKHRPQVAVI CGSGLGGLTD KLTQAQIFDY
60 70 80 90 100
SEIPNFPRST VPGHAGRLVF GFLNGRACVM MQGRFHMYEG YPLWKVTFPV
110 120 130 140 150
RVFHLLGVDT LVVTNAAGGL NPKFEVGDIM LIRDHINLPG FSGQNPLRGP
160 170 180 190 200
NDERFGDRFP AMSDAYDRTM RQRALSTWKQ MGEQRELQEG TYVMVAGPSF
210 220 230 240 250
ETVAECRVLQ KLGADAVGMS TVPEVIVARH CGLRVFGFSL ITNKVIMDYE
260 270 280
SLEKANHEEV LAAGKQAAQK LEQFVSVLMA SIPLPDKAS
Length:289
Mass (Da):32,120
Last modified:November 16, 2011 - v1
Checksum:i69769D6AA38D76FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030091990 Genomic DNA No translation available.
RefSeqiXP_018865130.1, XM_019009585.1

Genome annotation databases

EnsembliENSGGOT00000022353; ENSGGOP00000027451; ENSGGOG00000002126
GeneIDi101130944
KEGGiggo:101130944

Entry informationi

Entry nameiG3SH63_GORGO
AccessioniPrimary (citable) accession number: G3SH63
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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