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Protein

Sodium channel protein

Gene

SCN1A

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:SCN1AImported
OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Chromosome 2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei98 – 117HelicalUniRule annotationAdd BLAST20
Transmembranei129 – 151HelicalUniRule annotationAdd BLAST23
Transmembranei196 – 215HelicalUniRule annotationAdd BLAST20
Transmembranei227 – 248HelicalUniRule annotationAdd BLAST22
Transmembranei254 – 274HelicalUniRule annotationAdd BLAST21
Transmembranei403 – 430HelicalUniRule annotationAdd BLAST28
Transmembranei765 – 788HelicalUniRule annotationAdd BLAST24
Transmembranei800 – 821HelicalUniRule annotationAdd BLAST22
Transmembranei883 – 911HelicalUniRule annotationAdd BLAST29
Transmembranei970 – 996HelicalUniRule annotationAdd BLAST27
Transmembranei1223 – 1243HelicalUniRule annotationAdd BLAST21
Transmembranei1264 – 1283HelicalUniRule annotationAdd BLAST20
Transmembranei1339 – 1367HelicalUniRule annotationAdd BLAST29
Transmembranei1465 – 1489HelicalUniRule annotationAdd BLAST25
Transmembranei1548 – 1566HelicalUniRule annotationAdd BLAST19
Transmembranei1578 – 1596HelicalUniRule annotationAdd BLAST19
Transmembranei1608 – 1628HelicalUniRule annotationAdd BLAST21
Transmembranei1665 – 1693HelicalUniRule annotationAdd BLAST29
Transmembranei1769 – 1792HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSGGOG00000005441.

Interactioni

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000023417.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 437Ion_transInterPro annotationAdd BLAST306
Domaini509 – 722Na_trans_cytoplInterPro annotationAdd BLAST214
Domaini773 – 1000Ion_transInterPro annotationAdd BLAST228
Domaini1010 – 1208Na_trans_assocInterPro annotationAdd BLAST199
Domaini1224 – 1497Ion_transInterPro annotationAdd BLAST274
Domaini1547 – 1802Ion_transInterPro annotationAdd BLAST256

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00830000128242.
InParanoidiG3S5R1.
OMAiCMSNHTT.
OrthoDBiEOG091G00FK.
TreeFamiTF323985.

Family and domain databases

InterProiView protein in InterPro
IPR005821. Ion_trans_dom.
IPR008051. Na_channel_a1su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
PfamiView protein in Pfam
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
PRINTSiPR00170. NACHANNEL.
PR01664. NACHANNEL1.

Sequencei

Sequence statusi: Complete.

G3S5R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQTVLVPPG PDSFNFFTRE SLAAIERRIA EEKAKNPKPD KKDDDENGPK
60 70 80 90 100
PNSDLEAGKN LPFIYGDIPP EMVSEPLEDL DPYYINKKTF IVLNKGKAIF
110 120 130 140 150
RFSATSALYI LTPFNPLRKI AIKILVHSYP FSIFSMLIMC TILTNCVFMT
160 170 180 190 200
MSNPPDWTKN VEYTFTGIYT FESLIKIIAR GFCLEDFTFL RDPWNWLDFT
210 220 230 240 250
VITFAYVTEF VDLGNVSALR TFRVLRALKT ISVIPGLKTI VGALIQSVKK
260 270 280 290 300
LSDVMILTVF CLSVFALIGL QLFMGNLRNK CIQWPPTNAS LEEHSIEKNI
310 320 330 340 350
TVNYNGTLIN ETVFEFDWKS YIQDSRYHYF LEGFLDALLC GNSSDAGQCP
360 370 380 390 400
EGYMCVKAGR NPNYGYTSFD TFSWAFLSLF RLMTQDFWEN LYQLTLRAAG
410 420 430 440 450
KTYMIFFVLV IFLGSFYLIN LILAVVAMAY EEQNQATLEE AEQKEAEFQQ
460 470 480 490 500
MIEQLKKQQE AAQQAATATA SEHSREPSAA GRLSDSSSEA SKLSSKSAKE
510 520 530 540 550
RRNRRKKRKQ KEQSGGEEKD EDEFQKSESE DSIRRKGFRF SIEGNRLTYE
560 570 580 590 600
KRYSSPHQSL LSIRGSLFSP RRNSRTSLFS FRGRAKDVGS ENDFADDEHS
610 620 630 640 650
TFEDNESRRD SLFVPRRHAE RRNSNLSQTS RSSRMLAVFP ANGKMHSTVD
660 670 680 690 700
CNGVVSLVGG PSVPTSPVGQ LLPEVIIDKP ATDDNGTTTE TEMRKRRSSS
710 720 730 740 750
FHVSMDFLED PSQRQRAMSI ASILTNTVEE LEESRQKCPP CWYKFSNIFL
760 770 780 790 800
IWDCSPYWLK VKHVVNLVVM DPFVDLAITI CIVLNTLFMA MEHYPMTDHF
810 820 830 840 850
NNVLTVGNLV FTGIFTAEMF LKIIAMDPYY YFQEGWNIFD GFIVTLSLVE
860 870 880 890 900
LGLANVEGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV
910 920 930 940 950
LAIIVFIFAV VGMQLFGKSY KDCVCKIASD CQLPRWHMND FFHSFLIVFR
960 970 980 990 1000
VLCGEWIETM WDCMEVAGQA MCLTVFMMVM VIGNLVVLNL FLALLLSSFS
1010 1020 1030 1040 1050
ADNLAATDDD NEMNNLQIAV DRMHKGVAYV KRKIYEFIQQ SFIRKQKILD
1060 1070 1080 1090 1100
EIKPLDDLNN KKDSCMSNHT TEIGKDLDYL KDVNGTTSGI GTGSSVEKYI
1110 1120 1130 1140 1150
IDESDYMSFI NNPSLTVTVP IAVGESDFEN LNTEDFSSES DLEESKEKLN
1160 1170 1180 1190 1200
ESSSSSEGST VDIGAPAEEQ PVVEPEETLE PEACFTEECS LFSCWKTSVS
1210 1220 1230 1240 1250
NNCWMKWGIN TALETLYLNI TCYFTIFFLF FKHIFPSFFF FAFEDIYIDQ
1260 1270 1280 1290 1300
RKTIKTMLEY ADKVFTYIFI LEMLLKWVAY GYQTYFTNAW CWLDFLIVDV
1310 1320 1330 1340 1350
SLVSLTANAL GYSELGAIKS LRTLRALRPL RALSRFEGMR VVVNALLGAI
1360 1370 1380 1390 1400
PSIMNVLLVC LIFWLIFSIM GVNLFAGKFY HCINTTTGDR FDIEDVNNHT
1410 1420 1430 1440 1450
DCLKLIERNE TARWKNVKVN FDNVGFGYLS LLQVATFKGW MDIMYAAVDS
1460 1470 1480 1490 1500
RNVELQPKYE ESLYMYLYFV IFIIFGSFFT LNLFIGVIID NFNQQKKKFG
1510 1520 1530 1540 1550
GQDIFMTEEQ KKYYNAMKKL GSKKPQKPIP RPGNKFQGMV FDFVTRQVFD
1560 1570 1580 1590 1600
ISIMILICLN MVTMMVETDD QSEYVTTILS RINLVFIVLF TGECVLKLIS
1610 1620 1630 1640 1650
LRHYYFTIGW NIFDFVVVIL SIVGMFLAEL IEKYFVSPTL FRVIRLARIG
1660 1670 1680 1690 1700
RILRLIKGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY AIFGMSNFAY
1710 1720 1730 1740 1750
VKREVGIDDM FNFETFGNSM ICLFQITTSA GWDGLLAPIL NSKPPDCDPN
1760 1770 1780 1790 1800
KVNPGSSVKG DCGNPSVGIF FFVSYIIISF LVVVNMYIAV ILENFSVATE
1810 1820 1830 1840 1850
ESAEPLSEDD FEMFYEVWEK FDPDATQFME FEKLSQFAAA LEPPLNLPQP
1860 1870 1880 1890 1900
NKLQLIAMDL PMVSGDRIHC LDILFAFTKR VLGESGEMDA LRIQMEERFM
1910 1920 1930 1940 1950
ASNPSKVSYQ PITTTLKRKQ EEVSAVIIQR AYRRHLLKRT VKQASFTYNK
1960 1970 1980 1990 2000
NKIKGGANLL IKEDMIIDRI NENSITEKTD LTMSTAACPP SYDRVTKPIV
2010
EKHEQEGKDE KAKGD
Length:2,015
Mass (Da):229,804
Last modified:November 16, 2011 - v1
Checksum:iF36BFCD640D51FF6
GO

Genome annotation databases

EnsembliENSGGOT00000026827; ENSGGOP00000023417; ENSGGOG00000005441.

Similar proteinsi

Entry informationi

Entry nameiG3S5R1_GORGO
AccessioniPrimary (citable) accession number: G3S5R1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: July 5, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported