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Protein

Angiotensin-converting enzyme

Gene

ACE

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensin-converting enzymeUniRule annotation (EC:3.4.-.-UniRule annotation)
Gene namesi
Name:ACEImported
OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1268 – 1289HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500345308721 – 1314Angiotensin-converting enzymeSequence analysisAdd BLAST1294

Keywords - PTMi

GlycoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSGGOG00000000642.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000021381.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00520000055576.
InParanoidiG3RZY8.
OMAiVTMEQLF.
OrthoDBiEOG091G033S.
TreeFamiTF312861.

Family and domain databases

CDDicd06461. M2_ACE. 2 hits.
InterProiView protein in InterPro
IPR001548. Peptidase_M2.
PANTHERiPTHR10514. PTHR10514. 2 hits.
PfamiView protein in Pfam
PF01401. Peptidase_M2. 2 hits.
PRINTSiPR00791. PEPDIPTASEA.

Sequencei

Sequence statusi: Complete.

G3RZY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PGPAAGRCLT RPCLLPLGLG TATFFLSPPP PLPPALALDP GLQPGNFSAD
60 70 80 90 100
ETGAQLFAQS YNSSAEQVLF QSVAASWAHD TNITAENARR QEEAALLSQE
110 120 130 140 150
FAEAWGQKAK ELYEPIWQNF TDPQLRRIIG AVRTLGSANL PLAKRQQYNA
160 170 180 190 200
LLSNMSRIYS TTKVCLPNKT ATCWSLDPDL TNILASSRSY AMLLFAWEGW
210 220 230 240 250
HNAAGIPLKP LYKDFTALSN EAYKQDGFTD TGAYWRSWYN SPTFEDDLEH
260 270 280 290 300
LYQQLEPLYL NLHAFVRRAL HRRYGDRYIN LRGPIPAHLL GDMWAQSWEN
310 320 330 340 350
IYDMVVPFPD KPNLDVTSTM LQQGWNATHM FRVAEEFFTS LELSPMPPEF
360 370 380 390 400
WEGSMLEKPA DGREVVCHAS AWDFYNRKDF RIKQCTRITM DQLSTVHHEM
410 420 430 440 450
GHIQYYLQYK DLPVSLRGGA NPGFHEAIGD VLALSVSTPE HLYKIGLLDH
460 470 480 490 500
VTNDTESDIN YLLKMALEKI AFLPFGYLVD QWRWGVFSGR TPPSHYNFDW
510 520 530 540 550
WYLRTKYQGI CPPVTRNETH FDAGAKFHVP NVTPYIRYFV SFVLQFQFHE
560 570 580 590 600
ALCKEAGYEG PLHQCDIYQS TKAGAKLRKV LQAGSSRPWQ EVLKDMVGLD
610 620 630 640 650
ALDAQPLLKY FQPVTQWLQE QNQQNGEVLG WPEYQWHPPL PDNYPEGVDL
660 670 680 690 700
VTDEAEASKF VEEYDRTSQV VWNEYAEANW NYNTNITTET SKILLQKNMQ
710 720 730 740 750
IANHTLKYGT QARRFDVNQL QNTTIKRIIK KVQDLERAAL PAQELEEYNK
760 770 780 790 800
ILLDMETTYS VATVCHTNGS CLQLEPDLTN VMATSRKYED LLWAWEGWRD
810 820 830 840 850
KAGRAILQFY PKYVELINQA ARLNGYVDAG DSWRSMYETP SLEQDLERLF
860 870 880 890 900
QELQPLYLNL HAYVRRALHR HYGAQHINLE GPIPAHLLGN MWAQTWSNIY
910 920 930 940 950
DLVVPFPSAP SMDATEAMLK QGWTPRRMFK EADDFFTSLG LLPVPPEFWN
960 970 980 990 1000
KSMLEKPTDG REVVCHASAW DFYNGKDFRI KQCTTVNLED LVVAHHEMGH
1010 1020 1030 1040 1050
IQYFMQYKDL PVALREGANP GFHEAIGDVL ALSVSTPKHL HSLNLLSSEG
1060 1070 1080 1090 1100
GSDEHDINFL MKMALDKIAF IPFSYLVDQW RWRVFDGSIT KENYNQEWWS
1110 1120 1130 1140 1150
LRLKYQGLCP PVPRTQGDFD PGAKFHVPSS VPYIRYFVSF IIQFQFHEAL
1160 1170 1180 1190 1200
CQAAGHTGPL HKCDIYQSKE AGQRLATAMK LGFSRPWPEA MQLITGQPNM
1210 1220 1230 1240 1250
SASAMLSYFK PLLDWLRTEN ELHGEKLGWP QYNWTPNSAR SEGPLPDSGR
1260 1270 1280 1290 1300
VSFLGLDLDA QQARVGQWLL LFLGIALLVA TLGLSQRLFS IRHRSLHRHS
1310
HGPQFGSEVE LRHS
Length:1,314
Mass (Da):150,401
Last modified:November 16, 2011 - v1
Checksum:i0C47C8EEF1790FB0
GO

Genome annotation databases

EnsembliENSGGOT00000029973; ENSGGOP00000021381; ENSGGOG00000000642.

Similar proteinsi

Entry informationi

Entry nameiG3RZY8_GORGO
AccessioniPrimary (citable) accession number: G3RZY8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 25, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported