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G3QWE4

- G3QWE4_GORGO

UniProt

G3QWE4 - G3QWE4_GORGO

Protein
Submitted name:

Uncharacterized protein

Gene

PCSK2

Organism
Gorilla gorilla gorilla (Lowland gorilla)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: Ensembl

    GO - Biological processi

    1. enkephalin processing Source: Ensembl
    2. insulin processing Source: Ensembl
    3. nervous system development Source: Ensembl
    4. protein autoprocessing Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:PCSK2Imported
    OrganismiGorilla gorilla gorilla (Lowland gorilla)Imported
    Taxonomic identifieri9595 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
    ProteomesiUP000001519: Chromosome 20

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. membrane Source: Ensembl

    Structurei

    3D structure databases

    ProteinModelPortaliG3QWE4.
    SMRiG3QWE4. Positions 120-597.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S8 family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117358.
    KOiK01360.
    OMAiWLLEATF.
    OrthoDBiEOG7BW0JD.
    TreeFamiTF314277.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view]
    PANTHERiPTHR10795. PTHR10795. 1 hit.
    PfamiPF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view]
    PRINTSiPR00723. SUBTILISIN.
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3QWE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGGCVSQWK AAAGFLFCVM VFASAERPVF TNHFLVELHK GGEDEARQVA    50
    AEHGFGVRKL PFAEGLYHFY HNGLAKAKRR RSLHHKQQLE RDPRVKMALQ 100
    QEGFDRKKRG YRDINEIDIN MNDPLFTKQW YLINTGQADG TPGLDLNVAE 150
    AWELGYTGKG VTIGIMDDGI DYLHPDLASN YNAEASYDFS SNDPYPYPRY 200
    TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YNSKVAGIRM LDQPFMTDII 250
    EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK 300
    GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST 350
    LASTFSNGRK RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA 400
    NLGLTWRDMQ HLTVLTSKRN QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG 450
    AMVKMAKDWK TVPERFHCVG GSVQDPEKIP STGKLVLTLT TDACEGKENF 500
    VRYLEHVQAV ITVNATRRGD LNINMTSPMG TKSILLSRRP RDDDSKVGFD 550
    KWPFMTTHTW GEDARGTWTL ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI 600
    DQVVRDYQSK LAMSKKEELE EELDEAVERS LKSILNKN 638
    Length:638
    Mass (Da):70,566
    Last modified:November 16, 2011 - v1
    Checksum:i789B0D2EFD32F396
    GO

    Sequence databases

    RefSeqiXP_004061882.1. XM_004061834.1.

    Genome annotation databases

    EnsembliENSGGOT00000007288; ENSGGOP00000007101; ENSGGOG00000007255.
    GeneIDi101144581.
    KEGGiggo:101144581.

    Cross-referencesi

    Sequence databases

    RefSeqi XP_004061882.1. XM_004061834.1.

    3D structure databases

    ProteinModelPortali G3QWE4.
    SMRi G3QWE4. Positions 120-597.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGGOT00000007288 ; ENSGGOP00000007101 ; ENSGGOG00000007255 .
    GeneIDi 101144581.
    KEGGi ggo:101144581.

    Organism-specific databases

    CTDi 5126.

    Phylogenomic databases

    GeneTreei ENSGT00750000117358.
    KOi K01360.
    OMAi WLLEATF.
    OrthoDBi EOG7BW0JD.
    TreeFami TF314277.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view ]
    PANTHERi PTHR10795. PTHR10795. 1 hit.
    Pfami PF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view ]
    PRINTSi PR00723. SUBTILISIN.
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insights into the evolution of the great apes provided by the gorilla genome."
      Scally A.
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiG3QWE4_GORGO
    AccessioniPrimary (citable) accession number: G3QWE4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3