ID   G3QVV1_GORGO            Unreviewed;       717 AA.
AC   G3QVV1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=Choline transporter-like protein {ECO:0000256|RuleBase:RU368066};
GN   Name=SLC44A5 {ECO:0000313|Ensembl:ENSGGOP00000006887.3};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000006887.3, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000006887.3, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000006887.3, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000006887.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Choline transporter. {ECO:0000256|RuleBase:RU368066}.
CC   -!- FUNCTION: Choline/H+ antiporter. {ECO:0000256|ARBA:ARBA00037726}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=choline(out) + n H(+)(in) = choline(in) + n H(+)(out);
CC         Xref=Rhea:RHEA:75463, ChEBI:CHEBI:15354, ChEBI:CHEBI:15378;
CC         Evidence={ECO:0000256|ARBA:ARBA00035093};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU368066};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU368066}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CTL (choline transporter-like) family.
CC       {ECO:0000256|ARBA:ARBA00007168, ECO:0000256|RuleBase:RU368066}.
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DR   EMBL; CABD030003988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030003989; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030003990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030003991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030003992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030003993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030003994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030003995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030003996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030003997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_018875450.1; XM_019019905.1.
DR   AlphaFoldDB; G3QVV1; -.
DR   Ensembl; ENSGGOT00000007069.3; ENSGGOP00000006887.3; ENSGGOG00000007029.3.
DR   GeneID; 101139000; -.
DR   CTD; 204962; -.
DR   eggNOG; KOG1362; Eukaryota.
DR   GeneTree; ENSGT00940000156600; -.
DR   HOGENOM; CLU_017181_3_1_1; -.
DR   OrthoDB; 551961at2759; -.
DR   TreeFam; TF313325; -.
DR   Proteomes; UP000001519; Chromosome 1.
DR   Bgee; ENSGGOG00000007029; Expressed in testis and 3 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015220; F:choline transmembrane transporter activity; IEA:UniProt.
DR   GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:UniProt.
DR   InterPro; IPR007603; Choline_transptr-like.
DR   PANTHER; PTHR12385; CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44); 1.
DR   PANTHER; PTHR12385:SF42; CHOLINE TRANSPORTER-LIKE PROTEIN 5; 1.
DR   Pfam; PF04515; Choline_transpo; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368066};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU368066};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU368066}.
FT   TRANSMEM        39..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368066"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368066"
FT   TRANSMEM        269..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368066"
FT   TRANSMEM        325..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368066"
FT   TRANSMEM        366..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368066"
FT   TRANSMEM        463..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368066"
FT   TRANSMEM        608..632
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368066"
FT   TRANSMEM        653..673
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368066"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   717 AA;  81518 MW;  741A68ACC74B8C1E CRC64;
     MNDTEKPADT PSEEEDFGDP RTYDPDFKGP VANRSCTDVL CCMIFLLCII GYIVLGLVAW
     VHGDPRRAAY PTDSQGHFCG QKGTPNENKT ILFYFNLLRC TSPSVLLNLQ CPTTQICVSK
     CPEKFLTYVE MQLLYTKDKS YWEDYRQFCK TTAKPVKSLT QLLLDDDCPT AIFPSKPFLQ
     RCFPDFSTKN GTLTIGSKMV FQDGNGGTRS VVELGIAANG INKLLDAKSL GLKVFEDYAR
     TWYWILIGLT IAMVLSWIFL ILLRFIAGCL FWVFMIGVIG IIGYGIWHCY QQYTNLQERP
     SSVLTIYDIG IQTNISMYFE LQQTWFTFMI ILCIIEVIVI LMLIFLRNRI RVAIILLKEG
     SKAIGYVPST LVYPALTFIL LSICICYWVV TAVFLATSGV PVYKVIAPGG HCIHENQTCD
     PEIFNTTEIA KACPGALCNF AFYGGKSLYH QYIPTFHVYN LFVFLWLINF VTALGQCALA
     GAFATYYWAM KKPDDIPRYP LFTAFGRAIR YHTGSLAFGS LIIALIQMFK IVLEYLDHRL
     KRTQNTLSKF LQCCLRCCFW CLENAIKFLN RNAYIMIAIY GRNFCRSAKD AFNLLMRNVL
     KVAVTDEVTY FVLFLGKLLV AGSIGVLAFL FFTQRLPVIA QGPASLNYYW VPLLTVIFGS
     YLIAHGFFSV YAMCVETIFI CFLEDLERND GSTARPYYVS QPLLKIFQEE NPQTRKQ
//