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Protein

Mediator of RNA polymerase II transcription subunit 11

Gene

MED11

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 11UniRule annotation
Alternative name(s):
Mediator complex subunit 11UniRule annotation
Gene namesi
Name:MED11UniRule annotationImported
OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Chromosome 17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSGGOG00000005473.

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.UniRule annotation

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000005358.

Structurei

3D structure databases

ProteinModelPortaliG3QRU5.
SMRiG3QRU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 11 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000010184.
InParanoidiG3QRU5.
KOiK15131.
OMAiMTPPMER.
OrthoDBiEOG091G0YZ0.
TreeFamiTF318328.

Family and domain databases

InterProiView protein in InterPro
IPR019404. Mediator_Med11.
PfamiView protein in Pfam
PF10280. Med11. 1 hit.

Sequencei

Sequence statusi: Complete.

G3QRU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYSLANER LRALEDIERE IGAILQNAGT VILELSKEKT NERLLDRQAA
60 70 80 90 100
AFTASVQHVE AELSAQIRYL TQVATGQPHE GSSYSSRKDC QMALKRVDYA
110
RLKLSDVART CEQMLEN
Length:117
Mass (Da):13,129
Last modified:November 16, 2011 - v1
Checksum:iD01CAA8D211D6FC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030103303 Genomic DNA. No translation available.
RefSeqiXP_004058377.1. XM_004058329.2.

Genome annotation databases

EnsembliENSGGOT00000005499; ENSGGOP00000005358; ENSGGOG00000005473.
GeneIDi101133031.
KEGGiggo:101133031.

Similar proteinsi

Entry informationi

Entry nameiG3QRU5_GORGO
AccessioniPrimary (citable) accession number: G3QRU5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported