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G2Z9R5

- G2Z9R5_LISIP

UniProt

G2Z9R5 - G2Z9R5_LISIP

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Protein
ATP-dependent 6-phosphofructokinase
Gene
pfk, pfkA, LIV_1527
Organism
Listeria ivanovii (strain ATCC BAA-678 / PAM 55)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Enzyme regulationi

Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111ATP; via amide nitrogen By similarityUniRule annotation
Metal bindingi103 – 1031Magnesium; catalytic By similarityUniRule annotation
Active sitei127 – 1271Proton acceptor By similarityUniRule annotation
Binding sitei154 – 1541Allosteric activator ADP By similarityUniRule annotation
Binding sitei162 – 1621Substrate; shared with dimeric partner By similarityUniRule annotation
Binding sitei211 – 2111Allosteric activator ADP By similarityUniRule annotation
Binding sitei222 – 2221Substrate By similarityUniRule annotation
Binding sitei243 – 2431Substrate; shared with dimeric partner By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 732ATP By similarityUniRule annotation
Nucleotide bindingi102 – 1054ATP By similarityUniRule annotation

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent 6-phosphofructokinaseUniRule annotation (EC:2.7.1.11UniRule annotation)
Short name:
ATP-PFKUniRule annotation
Short name:
PhosphofructokinaseUniRule annotation
Alternative name(s):
Phosphohexokinase
Gene namesi
Name:pfkImported
Synonyms:pfkAUniRule annotation
Ordered Locus Names:LIV_1527Imported
OrganismiListeria ivanovii (strain ATCC BAA-678 / PAM 55)Imported
Taxonomic identifieri881621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000001286: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. 6-phosphofructokinase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliG2Z9R5.
SMRiG2Z9R5. Positions 1-319.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 255Allosteric activator ADP binding; shared with dimeric partner By similarityUniRule annotation
Regioni125 – 1273Substrate binding By similarityUniRule annotation
Regioni169 – 1713Substrate binding By similarityUniRule annotation
Regioni185 – 1873Allosteric activator ADP binding By similarityUniRule annotation
Regioni213 – 2153Allosteric activator ADP binding By similarityUniRule annotation
Regioni249 – 2524Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00850.

Family and domain databases

HAMAPiMF_00339. Phosphofructokinase.
InterProiIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
TIGRFAMsiTIGR02482. PFKA_ATP. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2Z9R5-1 [UniParc]FASTAAdd to Basket

« Hide

MKRIAILTSG GDAPGMNAAT RAVVRKAIYE GLEVYGINYG FLGLVNGDIR    50
KLELGSVGDL LHRGGTFLYS ARYPEFATEE GQLKGIEQLK KHQIDGLVVI 100
GGDGSYHGAE ALTKRGFPTI GIPGTIDNDI SGTDFTIGFD TALNTVLDAL 150
DKIRDTATSH ERTFIIEVMG RDAGDIALWS GLAGGAEAII VPEESFNMDD 200
VVDRLNKGRE RGKKHSIIVV AEGVMSGNEF AKQLAEYGDY HARVTVLGHV 250
QRGGSPTAFD RVLASRLGAR AVELLLENRG GLAVGIRENR IVENNIGEIL 300
KEKHTLDQKL FDLASILSI 319
Length:319
Mass (Da):34,373
Last modified:November 16, 2011 - v1
Checksum:i0F557F68891BBD95
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR687253 Genomic DNA. Translation: CBW86010.1.
RefSeqiYP_004855282.1. NC_016011.1.

Genome annotation databases

EnsemblBacteriaiCBW86010; CBW86010; LIV_1527.
GeneIDi11161737.
KEGGiliv:LIV_1527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FR687253 Genomic DNA. Translation: CBW86010.1 .
RefSeqi YP_004855282.1. NC_016011.1.

3D structure databases

ProteinModelPortali G2Z9R5.
SMRi G2Z9R5. Positions 1-319.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBW86010 ; CBW86010 ; LIV_1527 .
GeneIDi 11161737.
KEGGi liv:LIV_1527.

Phylogenomic databases

KOi K00850.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .

Family and domain databases

HAMAPi MF_00339. Phosphofructokinase.
InterProi IPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 1 hit.
TIGRFAMsi TIGR02482. PFKA_ATP. 1 hit.
PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the animal pathogen Listeria ivanovii, which provides insights into host specificities and evolution of the genus Listeria."
    Buchrieser C., Rusniok C., Garrido P., Hain T., Scortti M., Lampidis R., Karst U., Chakraborty T., Cossart P., Kreft J., Vazquez-Boland J.A., Goebel W., Glaser P.
    J. Bacteriol. 193:6787-6788(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-678 / PAM 55.

Entry informationi

Entry nameiG2Z9R5_LISIP
AccessioniPrimary (citable) accession number: G2Z9R5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: July 9, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Allosteric enzymeUniRule annotation, Complete proteome

External Data

Dasty 3

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