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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Flavobacterium branchiophilum (strain FL-15)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
Binding sitei258 – 2581NADPUniRule annotation
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi308 – 3136NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciFBRA1034807:GHGD-2973-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:FBFL15_2973Imported
OrganismiFlavobacterium branchiophilum (strain FL-15)Imported
Taxonomic identifieri1034807 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
ProteomesiUP000009186: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.
OMAiDVMSDMI.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2Z698-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIKVAHPV VELDGDEMTR IIWAFIKEKL ILPYLDLDIK YYDLGIESRE
60 70 80 90 100
ATKDQVTIDS AEAIKKYNVG IKCATITPDE ERVKEFGLSK MWKSPNGTIR
110 120 130 140 150
NIVGGTVFRE PIIMSNVPRY VQGWTKPIVI GRHAFGDQYK ATDVVVKGKG
160 170 180 190 200
KLTMTFVPEN GETQSWEVYD FEGDGVAMSM YNTDESIYGF AHSSFQMALT
210 220 230 240 250
KKWPLYLSTK NTILKAYDGR FKDIFEEVYQ TTYKADFEAN GMIYEHRLID
260 270 280 290 300
DMVASCMKWN GGFVWACKNY DGDVQSDTVA QGFGSLGLMT SVLVTPDGKT
310 320 330 340 350
VEAEAAHGTV TRHYRMHQQG KATSTNPIAS IFAWTRGLEH RGKLDDNQAL
360 370 380 390 400
IDFCTTLEQV CIDTVESGKM TKDLAMLVKP EGLTEADYLT TEGFLEAIKT

NLDAKLA
Length:407
Mass (Da):45,666
Last modified:November 16, 2011 - v1
Checksum:i701F6B8910F8336A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ859183 Genomic DNA. Translation: CCB70918.1.
RefSeqiWP_014085366.1. NC_016001.1.
YP_004845155.1. NC_016001.1.

Genome annotation databases

EnsemblBacteriaiCCB70918; CCB70918; FBFL15_2973.
GeneIDi11151363.
KEGGifbr:FBFL15_2973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FQ859183 Genomic DNA. Translation: CCB70918.1.
RefSeqiWP_014085366.1. NC_016001.1.
YP_004845155.1. NC_016001.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCCB70918; CCB70918; FBFL15_2973.
GeneIDi11151363.
KEGGifbr:FBFL15_2973.

Phylogenomic databases

KOiK00031.
OMAiDVMSDMI.

Enzyme and pathway databases

BioCyciFBRA1034807:GHGD-2973-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FL-15Imported.

Entry informationi

Entry nameiG2Z698_FLABF
AccessioniPrimary (citable) accession number: G2Z698
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: February 4, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.