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G2Z698

- G2Z698_FLABF

UniProt

G2Z698 - G2Z698_FLABF

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Flavobacterium branchiophilum (strain FL-15)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysis
    Sitei210 – 2101Critical for catalysisUniRule annotation
    Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
    Binding sitei258 – 2581NADPUniRule annotation
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi308 – 3136NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciFBRA1034807:GHGD-2973-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:FBFL15_2973Imported
    OrganismiFlavobacterium branchiophilum (strain FL-15)Imported
    Taxonomic identifieri1034807 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
    ProteomesiUP000009186: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OMAiKNTIMKV.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G2Z698-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIKVAHPV VELDGDEMTR IIWAFIKEKL ILPYLDLDIK YYDLGIESRE    50
    ATKDQVTIDS AEAIKKYNVG IKCATITPDE ERVKEFGLSK MWKSPNGTIR 100
    NIVGGTVFRE PIIMSNVPRY VQGWTKPIVI GRHAFGDQYK ATDVVVKGKG 150
    KLTMTFVPEN GETQSWEVYD FEGDGVAMSM YNTDESIYGF AHSSFQMALT 200
    KKWPLYLSTK NTILKAYDGR FKDIFEEVYQ TTYKADFEAN GMIYEHRLID 250
    DMVASCMKWN GGFVWACKNY DGDVQSDTVA QGFGSLGLMT SVLVTPDGKT 300
    VEAEAAHGTV TRHYRMHQQG KATSTNPIAS IFAWTRGLEH RGKLDDNQAL 350
    IDFCTTLEQV CIDTVESGKM TKDLAMLVKP EGLTEADYLT TEGFLEAIKT 400
    NLDAKLA 407
    Length:407
    Mass (Da):45,666
    Last modified:November 16, 2011 - v1
    Checksum:i701F6B8910F8336A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ859183 Genomic DNA. Translation: CCB70918.1.
    RefSeqiWP_014085366.1. NC_016001.1.
    YP_004845155.1. NC_016001.1.

    Genome annotation databases

    EnsemblBacteriaiCCB70918; CCB70918; FBFL15_2973.
    GeneIDi11151363.
    KEGGifbr:FBFL15_2973.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FQ859183 Genomic DNA. Translation: CCB70918.1 .
    RefSeqi WP_014085366.1. NC_016001.1.
    YP_004845155.1. NC_016001.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCB70918 ; CCB70918 ; FBFL15_2973 .
    GeneIDi 11151363.
    KEGGi fbr:FBFL15_2973.

    Phylogenomic databases

    KOi K00031.
    OMAi KNTIMKV.

    Enzyme and pathway databases

    BioCyci FBRA1034807:GHGD-2973-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FL-15Imported.

    Entry informationi

    Entry nameiG2Z698_FLABF
    AccessioniPrimary (citable) accession number: G2Z698
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3