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G2Z698 (G2Z698_FLABF) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108
EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Name:icd EMBL CCB70918.1
Ordered Locus Names:FBFL15_2973 EMBL CCB70918.1
OrganismFlavobacterium branchiophilum (strain FL-15) [Complete proteome] [HAMAP]
Taxonomic identifier1034807 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium ›

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding308 – 3136NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
G2Z698 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: 701F6B8910F8336A

FASTA40745,666
        10         20         30         40         50         60 
MAKIKVAHPV VELDGDEMTR IIWAFIKEKL ILPYLDLDIK YYDLGIESRE ATKDQVTIDS 

        70         80         90        100        110        120 
AEAIKKYNVG IKCATITPDE ERVKEFGLSK MWKSPNGTIR NIVGGTVFRE PIIMSNVPRY 

       130        140        150        160        170        180 
VQGWTKPIVI GRHAFGDQYK ATDVVVKGKG KLTMTFVPEN GETQSWEVYD FEGDGVAMSM 

       190        200        210        220        230        240 
YNTDESIYGF AHSSFQMALT KKWPLYLSTK NTILKAYDGR FKDIFEEVYQ TTYKADFEAN 

       250        260        270        280        290        300 
GMIYEHRLID DMVASCMKWN GGFVWACKNY DGDVQSDTVA QGFGSLGLMT SVLVTPDGKT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYRMHQQG KATSTNPIAS IFAWTRGLEH RGKLDDNQAL IDFCTTLEQV 

       370        380        390        400 
CIDTVESGKM TKDLAMLVKP EGLTEADYLT TEGFLEAIKT NLDAKLA

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References

[1]"Complete genome sequence of the fish pathogen Flavobacterium branchiophilum."
Touchon M., Barbier P., Bernardet J.F., Loux V., Vacherie B., Barbe V., Rocha E.P., Duchaud E.
Appl. Environ. Microbiol. 77:7656-7662(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FL-15.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FQ859183 Genomic DNA. Translation: CCB70918.1.
RefSeqYP_004845155.1. NC_016001.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCB70918; CCB70918; FBFL15_2973.
GeneID11151363.
KEGGfbr:FBFL15_2973.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.

Enzyme and pathway databases

BioCycFBRA1034807:GHGD-2973-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG2Z698_FLABF
AccessionPrimary (citable) accession number: G2Z698
Entry history
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: May 29, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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