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G2Z698

- G2Z698_FLABF

UniProt

G2Z698 - G2Z698_FLABF

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icd, FBFL15_2973
Organism
Flavobacterium branchiophilum (strain FL-15)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei210 – 2101Critical for catalysis By similarityUniRule annotation
Metal bindingi250 – 2501Magnesium or manganese By similarityUniRule annotation
Binding sitei258 – 2581NADP By similarityUniRule annotation
Metal bindingi273 – 2731Magnesium or manganese By similarityUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarityUniRule annotation
Nucleotide bindingi308 – 3136NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciFBRA1034807:GHGD-2973-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:FBFL15_2973Imported
OrganismiFlavobacterium branchiophilum (strain FL-15)
Taxonomic identifieri1034807 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
ProteomesiUP000009186: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.
OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G2Z698-1 [UniParc]FASTAAdd to Basket

« Hide

MAKIKVAHPV VELDGDEMTR IIWAFIKEKL ILPYLDLDIK YYDLGIESRE    50
ATKDQVTIDS AEAIKKYNVG IKCATITPDE ERVKEFGLSK MWKSPNGTIR 100
NIVGGTVFRE PIIMSNVPRY VQGWTKPIVI GRHAFGDQYK ATDVVVKGKG 150
KLTMTFVPEN GETQSWEVYD FEGDGVAMSM YNTDESIYGF AHSSFQMALT 200
KKWPLYLSTK NTILKAYDGR FKDIFEEVYQ TTYKADFEAN GMIYEHRLID 250
DMVASCMKWN GGFVWACKNY DGDVQSDTVA QGFGSLGLMT SVLVTPDGKT 300
VEAEAAHGTV TRHYRMHQQG KATSTNPIAS IFAWTRGLEH RGKLDDNQAL 350
IDFCTTLEQV CIDTVESGKM TKDLAMLVKP EGLTEADYLT TEGFLEAIKT 400
NLDAKLA 407
Length:407
Mass (Da):45,666
Last modified:November 16, 2011 - v1
Checksum:i701F6B8910F8336A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ859183 Genomic DNA. Translation: CCB70918.1.
RefSeqiWP_014085366.1. NC_016001.1.
YP_004845155.1. NC_016001.1.

Genome annotation databases

EnsemblBacteriaiCCB70918; CCB70918; FBFL15_2973.
GeneIDi11151363.
KEGGifbr:FBFL15_2973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FQ859183 Genomic DNA. Translation: CCB70918.1 .
RefSeqi WP_014085366.1. NC_016001.1.
YP_004845155.1. NC_016001.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCB70918 ; CCB70918 ; FBFL15_2973 .
GeneIDi 11151363.
KEGGi fbr:FBFL15_2973.

Phylogenomic databases

KOi K00031.
OMAi KNTIMKV.

Enzyme and pathway databases

BioCyci FBRA1034807:GHGD-2973-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FL-15.

Entry informationi

Entry nameiG2Z698_FLABF
AccessioniPrimary (citable) accession number: G2Z698
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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